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Protein Overview: SENP2

General Information:
Name(s) found: SENP2 [HGNC (HUGO)]
Description(s) found:
Found 22 descriptions.
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  • SUMO1/sentrin/SMT3 specific peptidase 2 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 589 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYRWLVRILG TIFRFCDRSV PPARALLKRR RSDSTLFSTV DTDEIPAKRP RLDCFIHQVK  60
   61 NSLYNAASLF GFPFQLTTKP MVTSACNGTR NVAPSGEVFS NSSSCELTGS GSWNNMLKLG 120
  121 NKSPNGISDY PKIRVTVTRD QPRRVLPSFG FTLNSEGCNR RPGGRRHSKG NPESSLMWKP 180
  181 QEQAVTEMIS EESGKGLRRP HCTVEEGVQK EEREKYRKLL ERLKESGHGN SVCPVTSNYH 240
  241 SSQRSQMDTL KTKGWGEEQN HGVKTTQFVP KQYRLVETRG PLCSLRSEKR CSKGKITDTE 300
  301 TMVGIRFENE SRRGYQLEPD LSEEVSARLR LGSGSNGLLR RKVSIIETKE KNCSGKERDR 360
  361 RTDDLLELTE DMEKEISNAL GHGPQDEILS SAFKLRITRG DIQTLKNYHW LNDEVINFYM 420
  421 NLLVERNKKQ GYPALHVFST FFYPKLKSGG YQAVKRWTKG VNLFEQEIIL VPIHRKVHWS 480
  481 LVVIDLRKKC LKYLDSMGQK GHRICEILLQ YLQDESKTKR NSDLNLLEWT HHSMKPHEIP 540
  541 QQLNGSDCGM FTCKYADYIS RDKPITFTQH QMPLFRKKMV WEILHQQLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..71] deduced N/A No confident structure predictions are available.
    2 View Details [72..263] MSA 3.335994 View MSA. No confident structure predictions are available.
    3 View Details [264..365] deduced N/A No confident structure predictions are available.
    4 View Details [366..589] PSI-BLAST 65.69897 Structure of human Senp2 in complex with SUMO-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • SUMO-specific protease activity
    		•  7.14791995103471 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  6.54685807643041 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  6.39247995905454 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.52987342617304 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  3.91170685383331 bayes_pls_golite062009
  • peptidase activity
    		•  2.99092799770282 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.70509346529146 bayes_pls_golite062009
  • hydrolase activity
    		•  2.66167923792227 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.56654871607946 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.1617608442198 bayes_pls_golite062009
  • binding
    		•  1.92046698500094 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.79166977301695 bayes_pls_golite062009
  • signal transducer activity
    		•  1.5684982941305 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.5684982941305 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.874003454509364 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.687958315289315 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.439226369799415 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.354062437867002 bayes_pls_golite062009
  • DNA binding
    		•  0.306964954191276 bayes_pls_golite062009
  • calcium-dependent cysteine-type endopeptidase activity
    		•  0.196538841514154 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.144331158319621 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle