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Protein Overview: HGNC:16882|MIM:6...

General Information:
Name(s) found: HGNC:16882|MIM:605206|Ensembl:ENSG00000138622|HPRD:09240,HsxXG003541,G04,HsCD00302976,470533.0,pANT7_cGST,FUSION,NM_005477,10021.0,HCN4,SSS2,hyperpolarization [120926-122011-mus-fusion.fasta]
Description(s) found:
  • activated cyclic nucleotide-gated potassium channel 4 [120926-122011-mus-fusion.fasta]
    • Organism: SPECIES UNKNOWN
    Length: 1203 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLPPSMRK RLYSLPQQVG AKAWIMDEEE DAEEEGAGGR QDPSRRSIRL RPLPSPSPSA  60
   61 AAGGTESRSS ALGAADSEGP ARGAGKSSTN GDCRRFRGSL ASLGSRGGGS GGTGSGSSHG 120
  121 HLHDSAEERR LIAEGDASPG EDRTPPGLAA EPERPGASAQ PAASPPPPQQ PPQPASASCE 180
  181 QPSVDTAIKV EGGAAAGDQI LPEAEVRLGQ AGFMQRQFGA MLQPGVNKFS LRMFGSQKAV 240
  241 EREQERVKSA GFWIIHPYSD FRFYWDLTML LLMVGNLIII PVGITFFKDE NTTPWIVFNV 300
  301 VSDTFFLIDL VLNFRTGIVV EDNTEIILDP QRIKMKYLKS WFMVDFISSI PVDYIFLIVE 360
  361 TRIDSEVYKT ARALRIVRFT KILSLLRLLR LSRLIRYIHQ WEEIFHMTYD LASAVVRIVN 420
  421 LIGMMLLLCH WDGCLQFLVP MLQDFPDDCW VSINNMVNNS WGKQYSYALF KAMSHMLCIG 480
  481 YGRQAPVGMS DVWLTMLSMI VGATCYAMFI GHATALIQSL DSSRRQYQEK YKQVEQYMSF 540
  541 HKLPPDTRQR IHDYYEHRYQ GKMFDEESIL GELSEPLREE IINFNCRKLV ASMPLFANAD 600
  601 PNFVTSMLTK LRFEVFQPGD YIIREGTIGK KMYFIQHGVV SVLTKGNKET KLADGSYFGE 660
  661 ICLLTRGRRT ASVRADTYCR LYSLSVDNFN EVLEEYPMMR RAFETVALDR LDRIGKKNSI 720
  721 LLHKVQHDLN SGVFNYQENE IIQQIVQHDR EMAHCAHRVQ AAASATPTPT PVIWTPLIQA 780
  781 PLQAAAATTS VAIALTHHPR LPAAIFRPPP GSGLGNLGAG QTPRHLKRLQ SLIPSALGSA 840
  841 SPASSPSQVD TPSSSSFHIQ QLAGFSAPAG LSPLLPSSSS SPPPGACGSP SAPTPSAGVA 900
  901 ATTIAGFGHF HKALGGSLSS SDSPLLTPLQ PGARSPQAAQ PSPAPPGARG GLGLPEHFLP 960
  961 PPPSSRSPSS SPGQLGQPPG ELSLGLATGP LSTPETPPRQ PEPPSLVAGA SGGASPVGFT1020
 1021 PRGGLSPPGH SPGPPRTFPS APPRASGSHG SLLLPPASSP PPPQVPQRRG TPPLTPGRLT1080
 1081 QDLKLISASQ PALPQDGAQT LRRASPHSSG ESMAAFPLFP RAGGGSGGSG SSGGLGPPGR1140
 1141 PYGAIPGQHV TLPRKTSSGS LPPPLSLFGA RATSSGGPPL TAGPQREPGA RPEPVRSKLP1200
 1201 SNL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] deduced N/A No confident structure predictions are available.
    2 View Details [177..287] Pfam 55.366532 No description for PF08412.1 was found. No confident structure predictions are available.
    3 View Details [288..525] PSI-BLAST 28.30103 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    4 View Details [526..592] PSI-BLAST 63.69897 HCN2J 443-645 in the presence of cGMP
    5 View Details [593..740] PSI-BLAST 10.221849 Regulatory domain of epac2, domain 2; Regulatory domain of Epac2, domains 1 and 3
    6 View Details [741..1203] PSI-BLAST 5.0 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • intracellular cyclic nucleotide activated cation channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  9.72053268940283 bayes_pls_golite062009
  • cation channel activity
    		•  9.48749374439976 bayes_pls_golite062009
  • ion channel activity
    		•  9.4846197809463 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  9.3929063879608 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  9.25176207085973 bayes_pls_golite062009
  • channel activity
    		•  9.25176207085973 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  9.2472549851376 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • gated channel activity
    		•  9.19042473454294 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.57272328088253 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.54930851487319 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.54400173845933 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.34760703274696 bayes_pls_golite062009
  • potassium channel activity
    		•  5.29889968906368 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.1138025954757 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  4.96516802098805 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  4.52895684111035 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.95109938608832 bayes_pls_golite062009
  • transporter activity
    		•  3.30740141256752 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.24402760485462 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.22443361822344 bayes_pls_golite062009
  • binding
    		•  1.10631659705555 bayes_pls_golite062009
  • protein binding
    		•  0.79369425144072 bayes_pls_golite062009
  • signal transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
    5
    Term Confidence Notes
  • intracellular cyclic nucleotide activated cation channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  10.1422916734545 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  9.72053268940283 bayes_pls_golite062009
  • cation channel activity
    		•  9.48749374439976 bayes_pls_golite062009
  • ion channel activity
    		•  9.4846197809463 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  9.3929063879608 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  9.25176207085973 bayes_pls_golite062009
  • channel activity
    		•  9.25176207085973 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  9.2472549851376 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • gated channel activity
    		•  9.19042473454294 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.57272328088253 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.54930851487319 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.54400173845933 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.34760703274696 bayes_pls_golite062009
  • potassium channel activity
    		•  5.29889968906368 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.1138025954757 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  4.96516802098805 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  4.52895684111035 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  3.95109938608832 bayes_pls_golite062009
  • transporter activity
    		•  3.30740141256752 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.24402760485462 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.22443361822344 bayes_pls_golite062009
  • binding
    		•  1.10631659705555 bayes_pls_golite062009
  • protein binding
    		•  0.79369425144072 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.5243910425301 bayes_pls_golite062009
  • signal transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.202809682876964 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle