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Protein Overview: MSH1_YEAST

General Information:
Name(s) found: MSH1_YEAST [Swiss-Prot]
Description(s) found:
  • DNA mismatch repair protein MSH1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH1 PE=1 SV=2 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 959 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKHFFRLPTA FRPISRVSLR YSSTDTAQPK ISKLKISFNK ISESNSEKKD NLGSIDTRNC  60
   61 LSTQQDDKLS STEPSKASLP PSLQYVRDLM DLYKDHVVLT QMGSFYELYF EQAIRYAPEL 120
  121 NISLTNRAYS HGKVPFAGFP VHQLSRHLKM LVNNCGYSVT IAEQFKKKDV ADNEANKFYR 180
  181 RVTRIVTPGT FIDEAFENLR ENTYLLNIEF PENCMSQVAD TSLKVGICWC DVSTGEIFVQ 240
  241 QVYLRDLVSA ITRIQPKEIL LDERLLEFHI ESGTWYPELV ELKKFFIKYQ KMPSQHRTIE 300
  301 SFYGLFNLGG KEATERQLKI QFQTFTQKEL AALRNTLIYV SNHLPDFSIN FQIPQRQLAT 360
  361 AIMQIDSRTS TALELHSTVR DNNKKGSLLS SIRRTVTPSG TRLLSQWLSG PSLDLKEIKK 420
  421 RQKIVAFFKD NRDITETLRT MLKKVNDLSR ILQKFSFGRG EALELIQMAR SLEVSREIRK 480
  481 YLLNNTSLMK ATLKSQITQL TESLNFEKNL IDDILKFLNE EELAKSQDAK QNADVTRMLD 540
  541 IDVKDKKESN KDEIFELRDF IVNPSFNTKL RKLHDTYQGV WQKKTEYNAL LKGFFVGDLG 600
  601 AKTFTLKERQ NGEYALHVTG TASSLKKIDE LISKSTEYHG SCFHILQKSS QTRWLSHKIW 660
  661 TDLGHELELL NLKIRNEEAN IIDLFKRKFI DRSNEVRQVA TTLGYLDTLS SFAVLANERN 720
  721 LVCPKVDESN KLEVVNGRHL MVEEGLSARS LETFTANNCE LAKDNLWVIT GPNMGGKSTF 780
  781 LRQNAIIVIL AQIGCFVPCS KARVGIVDKL FSRVGSADDL YNEMSTFMVE MIETSFILQG 840
  841 ATERSLAILD EIGRGTSGKE GISIAYATLK YLLENNQCRT LFATHFGQEL KQIIDNKCSK 900
  901 GMSEKVKFYQ SGITDLGGNN FCYNHKLKPG ICTKSDAIRV AELAGFPMEA LKEAREILG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..68] deduced N/A No confident structure predictions are available.
    2 View Details [69..185] PSI-BLAST 1421.54902 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    3 View Details [186..360] PSI-BLAST 1421.54902 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    4 View Details [361..386]
    [717..959]    		 PSI-BLAST 1421.54902 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    5 View Details [387..577]
    [669..716]    		 PSI-BLAST 1421.54902 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
    6 View Details [578..668] PSI-BLAST 1421.54902 DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • mismatched DNA binding
    		•  2.51625633651862 bayes_pls_golite062009
  • binding
    		•  2.4974940028864 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.10134737488849 bayes_pls_golite062009
  • double-strand/single-strand DNA junction binding
    		•  2.02697209084624 bayes_pls_golite062009
    		• 1.85506769032946 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.84050240798436 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.81138802583782 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.78927528875848 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.78903889318615 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.71882026185027 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • guanine/thymine mispair binding
    		•  1.69026972999845 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  1.68890613599528 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.6537049553461 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.63960194106079 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.61735400124552 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.60768715809391 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.60404584546501 bayes_pls_golite062009
  • oxidized purine DNA binding
    		•  1.30673778631233 bayes_pls_golite062009
  • oxidized DNA binding
    		•  1.30673778631233 bayes_pls_golite062009
  • single guanine insertion binding
    		•  1.30673778631233 bayes_pls_golite062009
  • hydrolase activity
    		•  1.29419296935491 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • ATPase activity
    		•  1.18431260772292 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • DNA binding
    		•  1.11699929651302 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  1.08464552192299 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.02269224635866 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.989226939888218 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.987648886158896 bayes_pls_golite062009
  • DNA clamp loader activity
    		•  0.91282941965371 bayes_pls_golite062009
  • dinucleotide repeat insertion binding
    		•  0.645326857719269 bayes_pls_golite062009
  • single base insertion or deletion binding
    		•  0.629563765934841 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • protein binding
    		•  0.193768631623192 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0434163635422169 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle