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Protein Overview: HST1_YEAST

General Information:
Name(s) found: HST1_YEAST [Swiss-Prot]
Description(s) found:
Found 2 descriptions.
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  • NAD-dependent protein deacetylase HST1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Saccharomyces cerevisiae S288c
    Length: 503 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNILLMQRIV SFILVVSQGR YFHVGELTMT MLKRPQEEES DNNATKKLKT RLTYPCILGK  60
   61 DKVTGKFIFP AITKDDVMNA RLFLKDNDLK TFLEYFLPVE VNSIYIYFMI KLLGFDVKDK 120
  121 ELFMALNSNI TSNKERSSAE LSSIHAKAED EDELTDPLEK KHAVKLIKDL QKAINKVLST 180
  181 RLRLPNFNTI DHFTATLRNA KKILVLTGAG VSTSLGIPDF RSSEGFYSKI RHLGLEDPQD 240
  241 VFNLDIFLQD PSVFYNIAHM VLPPENMYSP LHSFIKMLQD KGKLLRNYTQ NIDNLESYAG 300
  301 IDPDKLVQCH GSFATASCVT CHWQIPGEKI FENIRNLELP LCPYCYQKRK QYFPMSNGNN 360
  361 TVQTNINFNS PILKSYGVLK PDMTFFGEAL PSRFHKTIRK DILECDLLIC IGTSLKVAPV 420
  421 SEIVNMVPSH VPQILINRDM VTHAEFDLNL LGFCDDVASL VAKKCHWDIP HKKWQDLKKI 480
  481 DYNCTEIDKG TYKIKKQPRK KQQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] deduced N/A No confident structure predictions are available.
    2 View Details [146..219]
    [263..312]
    [391..503]    		 PSI-BLAST 475.39794 Sirt2 histone deacetylase
    3 View Details [220..262]
    [313..390]    		 PSI-BLAST 475.39794 Sirt2 histone deacetylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein deacetylase activity
    		•  11.8771442637949 bayes_pls_golite062009
  • histone deacetylase activity
    		•  11.7308825525122 bayes_pls_golite062009
  • deacetylase activity
    		•  10.8368006972109 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  8.53375308475286 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  8.13038616303736 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  7.0185004322765 bayes_pls_golite062009
  • tubulin deacetylase activity
    		•  4.98963898611597 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  4.62921662347995 bayes_pls_golite062009
  • histone deacetylase activity (H3-K9 specific)
    		•  3.19556696137433 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.9155913558118 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H4-K16 specific)
    		•  2.54548484159934 bayes_pls_golite062009
  • DNA binding
    		•  2.43141001866996 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.41433477472968 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.24657784428979 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • NAD-independent histone deacetylase activity
    		•  2.03444106183496 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.64212790017753 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43067365161346 bayes_pls_golite062009
  • transcription factor activity
    		•  1.30143289828088 bayes_pls_golite062009
  • histone deacetylase activity (H3-K14 specific)
    		•  1.2707802007556 bayes_pls_golite062009
  • transcription factor binding
    		•  1.14766678956419 bayes_pls_golite062009
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity
    		•  0.963519974868694 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.54005617175343 bayes_pls_golite062009
  • protein binding
    		•  0.475479132768057 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K14 specific)
    		•  0.412196364170961 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity (H3-K9 specific)
    		•  0.412196364170961 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle