| Protein: | HST1_YEAST |
| Organism: | Saccharomyces cerevisiae S288c |
| Length: | 503 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HST1_YEAST.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..503] | [1..503] |
|
|
0.0 | [54..494] | [155..609] |
|
|
0.0 | [65..475] | [91..489] |
|
|
4.0E-91 | [150..495] | [24..362] |
|
|
1.0E-90 | [116..465] | [120..480] |
|
|
1.0E-88 | [150..495] | [24..362] |
|
Region A: Residues: [1-145] |
1 11 21 31 41 51
| | | | | |
1 MNILLMQRIV SFILVVSQGR YFHVGELTMT MLKRPQEEES DNNATKKLKT RLTYPCILGK 60
61 DKVTGKFIFP AITKDDVMNA RLFLKDNDLK TFLEYFLPVE VNSIYIYFMI KLLGFDVKDK 120
121 ELFMALNSNI TSNKERSSAE LSSIH
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [146-219] |
1 11 21 31 41 51
| | | | | |
1 AKAEDEDELT DPLEKKHAVK LIKDLQKAIN KVLSTRLRLP NFNTIDHFTA TLRNAKKILV 60
61 LTGAGVSTSL GIPD
|
|
Region B: Residues: [263-312] |
1 11 21 31 41 51
| | | | | |
1 PPENMYSPLH SFIKMLQDKG KLLRNYTQNI DNLESYAGID PDKLVQCHGS
|
|
Region C: Residues: [391-503] |
1 11 21 31 41 51
| | | | | |
1 PSRFHKTIRK DILECDLLIC IGTSLKVAPV SEIVNMVPSH VPQILINRDM VTHAEFDLNL 60
61 LGFCDDVASL VAKKCHWDIP HKKWQDLKKI DYNCTEIDKG TYKIKKQPRK KQQ
|
| Detection Method: | |
| Confidence: | 475.39794 |
| Match: | 1j8fA_ |
| Description: | Sirt2 histone deacetylase |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein deacetylase activity | 11.8771442637949 | bayes_pls_golite062009 |
| histone deacetylase activity | 11.7308825525122 | bayes_pls_golite062009 |
| deacetylase activity | 10.8368006972109 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | 8.53375308475286 | bayes_pls_golite062009 |
| NAD-dependent protein deacetylase activity | 8.13038616303736 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity | 8.13038616303736 | bayes_pls_golite062009 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | 7.0185004322765 | bayes_pls_golite062009 |
| tubulin deacetylase activity | 4.98963898611597 | bayes_pls_golite062009 |
| NAD+ ADP-ribosyltransferase activity | 4.62921662347995 | bayes_pls_golite062009 |
| histone deacetylase activity (H3-K9 specific) | 3.19556696137433 | bayes_pls_golite062009 |
| transcription regulator activity | 2.9155913558118 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H4-K16 specific) | 2.54548484159934 | bayes_pls_golite062009 |
| DNA binding | 2.43141001866996 | bayes_pls_golite062009 |
| nucleic acid binding | 2.41433477472968 | bayes_pls_golite062009 |
| transcription repressor activity | 2.24657784428979 | bayes_pls_golite062009 |
| binding | 2.06552694538163 | bayes_pls_golite062009 |
| NAD-independent histone deacetylase activity | 2.03444106183496 | bayes_pls_golite062009 |
| transcription corepressor activity | 1.64212790017753 | bayes_pls_golite062009 |
| hydrolase activity | 1.43067365161346 | bayes_pls_golite062009 |
| transcription factor activity | 1.30143289828088 | bayes_pls_golite062009 |
| histone deacetylase activity (H3-K14 specific) | 1.2707802007556 | bayes_pls_golite062009 |
| transcription factor binding | 1.14766678956419 | bayes_pls_golite062009 |
| NAD(P)+-protein-arginine ADP-ribosyltransferase activity | 0.963519974868694 | bayes_pls_golite062009 |
| catalytic activity | 0.739210399081789 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.54005617175343 | bayes_pls_golite062009 |
| protein binding | 0.475479132768057 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H3-K14 specific) | 0.412196364170961 | bayes_pls_golite062009 |
| NAD-dependent histone deacetylase activity (H3-K9 specific) | 0.412196364170961 | bayes_pls_golite062009 |
|
Region A: Residues: [220-262] |
1 11 21 31 41 51
| | | | | |
1 FRSSEGFYSK IRHLGLEDPQ DVFNLDIFLQ DPSVFYNIAH MVL
|
|
Region B: Residues: [313-390] |
1 11 21 31 41 51
| | | | | |
1 FATASCVTCH WQIPGEKIFE NIRNLELPLC PYCYQKRKQY FPMSNGNNTV QTNINFNSPI 60
61 LKSYGVLKPD MTFFGEAL
|
| Detection Method: | |
| Confidence: | 475.39794 |
| Match: | 1j8fA_ |
| Description: | Sirt2 histone deacetylase |
| Matching Structure (courtesy of the PDB): |
|
