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Protein Overview: EG11001

General Information:
Name(s) found: thrS / EG11001 [EcoGene]
Description(s) found:
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  • threonyl-tRNA synthetase / Threonine--tRNA ligase, autogenously regulated; binds Zn(II) [EcoGene]
  • threonyl-tRNA synthetase [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • threonyl-tRNA synthetase [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][IEA]
    Biological Process: tRNA aminoacylation for protein translation [IDALink to PubMed article]
    negative regulation of translational initiation [IMPLink to PubMed article]
    threonyl-tRNA aminoacylation [IDALink to PubMed articleLink to PubMed article][IEA]
    tRNA aminoacylation [IDALink to PubMed article]
    Molecular Function: nucleotide binding [IEA]
    ligase activity, forming aminoacyl-tRNA and related compounds [IDALink to PubMed article]
    ATP binding [IDALink to PubMed article][IEA]
    zinc ion binding [IEA][IMPLink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed article]
    RNA binding [IDALink to PubMed article][IEA]
    drug binding [IDALink to PubMed article]
    threonine-tRNA ligase activity [IDALink to PubMed articleLink to PubMed article][IEA]
    translation repressor activity, nucleic acid binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVITLPDGS QRHYDHAVSP MDVALDIGPG LAKACIAGRV NGELVDACDL IENDAQLSII  60
   61 TAKDEEGLEI IRHSCAHLLG HAIKQLWPHT KMAIGPVIDN GFYYDVDLDR TLTQEDVEAL 120
  121 EKRMHELAEK NYDVIKKKVS WHEARETFAN RGESYKVSIL DENIAHDDKP GLYFHEEYVD 180
  181 MCRGPHVPNM RFCHHFKLMK TAGAYWRGDS NNKMLQRIYG TAWADKKALN AYLQRLEEAA 240
  241 KRDHRKIGKQ LDLYHMQEEA PGMVFWHNDG WTIFRELEVF VRSKLKEYQY QEVKGPFMMD 300
  301 RVLWEKTGHW DNYKDAMFTT SSENREYCIK PMNCPGHVQI FNQGLKSYRD LPLRMAEFGS 360
  361 CHRNEPSGSL HGLMRVRGFT QDDAHIFCTE EQIRDEVNGC IRLVYDMYST FGFEKIVVKL 420
  421 STRPEKRIGS DEMWDRAEAD LAVALEENNI PFEYQLGEGA FYGPKIEFTL YDCLDRAWQC 480
  481 GTVQLDFSLP SRLSASYVGE DNERKVPVMI HRAILGSMER FIGILTEEFA GFFPTWLAPV 540
  541 QVVIMNITDS QSEYVNELTQ KLSNAGIRVK ADLRNEKIGF KIREHTLRRV PYMLVCGDKE 600
  601 VESGKVAVRT RRGKDLGSMD VNEVIEKLQQ EIRSRSLKQL EE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..642] PSI-BLAST 166.0 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  6.47381405106149 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  2.99105702052936 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.29229136935761 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • binding
    		•  1.11470390774037 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.0753492604686 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.897558352141977 bayes_pls_golite062009
  • DNA binding
    		•  0.854148126675211 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.55217603492525 bayes_pls_golite062009
  • transcription factor activity
    		•  0.283508546234551 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle