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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Any process that stops, prevents or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA. The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress. Any process involving iron that stops, prevents or reduces the rate of translational initiation. Any process that modulates the frequency, rate or extent of translational initiation. Any process that stops, prevents or reduces the frequency, rate or extent of translational initiation. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of translational initiation
Acc: GO:0045947
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of translational initiation.
Synonyms:
  • down-regulation of translational initiation
  • inhibition of translational initiation
  • down regulation of translational initiation
  • downregulation of translational initiation
Proteins in PDR annotated with:
   This term: 23 [Search]
   Term or descendants: 31 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045947 - negative regulation of translational initiation (interactive image map)
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