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Protein Overview: EG10240

General Information:
Name(s) found: dnaJ / EG10240 [EcoGene]
Description(s) found:
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  • chaperone Hsp40, DnaK co-chaperone / DnaK co-chaperone HSP40; DNA-binding protein; stress-related DNA biosynthesis, responsive to heat shock; binds Zn(II) [EcoGene]
  • chaperone Hsp40, co-chaperone with DnaK [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • chaperone Hsp40, co-chaperone with DnaK [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article][IEA]
    Biological Process: response to heat [IEA][IEPLink to PubMed article]
    DNA replication [IEA][IMPLink to PubMed article]
    protein refolding [IDALink to PubMed article]
    protein folding [IDALink to PubMed article][IEA]
    response to stress [IEA]
    Molecular Function: heat shock protein binding [IEA]
    ATP binding [IEA]
    zinc ion binding [IDALink to PubMed articleLink to PubMed article][IEA][IMPLink to PubMed article]
    protein homodimerization activity [IDALink to PubMed article]
    protein binding [IMPLink to PubMed article][IPILink to PubMed article]
    protein disulfide isomerase activity [IDALink to PubMed article]
    unfolded protein binding [IDALink to PubMed article][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKQDYYEIL GVSKTAEERE IRKAYKRLAM KYHPDRNQGD KEAEAKFKEI KEAYEVLTDS  60
   61 QKRAAYDQYG HAAFEQGGMG GGGFGGGADF SDIFGDVFGD IFGGGRGRQR AARGADLRYN 120
  121 MELTLEEAVR GVTKEIRIPT LEECDVCHGS GAKPGTQPQT CPTCHGSGQV QMRQGFFAVQ 180
  181 QTCPHCQGRG TLIKDPCNKC HGHGRVERSK TLSVKIPAGV DTGDRIRLAG EGEAGEHGAP 240
  241 AGDLYVQVQV KQHPIFEREG NNLYCEVPIN FAMAALGGEI EVPTLDGRVK LKVPGETQTG 300
  301 KLFRMRGKGV KSVRGGAQGD LLCRVVVETP VGLNERQKQL LQELQESFGG PTGEHNSPRS 360
  361 KSFFDGVKKF FDDLTR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] PSI-BLAST 23.0 NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
    2 View Details [132..200] PSI-BLAST 15.39794 Cysteine-rich domain of the chaperone protein DnaJ.
    3 View Details [201..376] FFAS03 6.27 No description for 2b26A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  3.04403163860617 bayes_pls_golite062009
  • heat shock protein binding
    		•  2.17994194200939 bayes_pls_golite062009
  • binding
    		•  2.03854863870179 bayes_pls_golite062009
  • chaperone binding
    		•  1.61155546076854 bayes_pls_golite062009
  • protein binding
    		•  1.35701123337504 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.2131700498174 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.12971478797926 bayes_pls_golite062009
  • DNA binding
    		•  0.8788643398536 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  0.541755903922701 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein disulfide isomerase activity
    		•  2.4409950647303 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  2.4409950647303 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  2.23398279564144 bayes_pls_golite062009
  • binding
    		•  2.13705208493215 bayes_pls_golite062009
  • unfolded protein binding
    		•  2.04158808514315 bayes_pls_golite062009
  • protein binding
    		•  1.32690171510656 bayes_pls_golite062009
  • catalytic activity
    		•  0.276917867171685 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle