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Protein Overview: EG10463

General Information:
Name(s) found: degP / EG10463 [EcoGene]
Description(s) found:
Found 4 descriptions.
SHOW ALL
  • serine endoprotease (protease Do), membrane-associated / Periplasmic, membrane-associated serine endoprotease; protease Do, required for high-temperature growth and the degradation of damaged proteins, primarily outer membrane proteins [EcoGene]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 474 amino acids

    Gene Ontology:
    Cellular Component: outer membrane-bounded periplasmic space [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IEPLink to PubMed article]
    misfolded or incompletely synthesized protein catabolic process [IMPLink to PubMed article]
    response to temperature stimulus [IEPLink to PubMed article]
    proteolysis [IDALink to PubMed article][IEA]
    protein folding [IMPLink to PubMed article]
    response to stress [IEA]
    Molecular Function: protein binding [IDALink to PubMed article][IEA][IPILink to PubMed article]
    catalytic activity [IEA]
    serine-type endopeptidase activity [IDALink to PubMed article][IEA][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTTLALSA LALSLGLALS PLSATAAETS SATTAQQMPS LAPMLEKVMP SVVSINVEGS  60
   61 TTVNTPRMPR NFQQFFGDDS PFCQEGSPFQ SSPFCQGGQG GNGGGQQQKF MALGSGVIID 120
  121 ADKGYVVTNN HVVDNATVIK VQLSDGRKFD AKMVGKDPRS DIALIQIQNP KNLTAIKMAD 180
  181 SDALRVGDYT VAIGNPFGLG ETVTSGIVSA LGRSGLNAEN YENFIQTDAA INRGNSGGAL 240
  241 VNLNGELIGI NTAILAPDGG NIGIGFAIPS NMVKNLTSQM VEYGQVKRGE LGIMGTELNS 300
  301 ELAKAMKVDA QRGAFVSQVL PNSSAAKAGI KAGDVITSLN GKPISSFAAL RAQVGTMPVG 360
  361 SKLTLGLLRD GKQVNVNLEL QQSSQNQVDS SSIFNGIEGA EMSNKGKDQG VVVNNVKTGT 420
  421 PAAQIGLKKG DVIIGANQQA VKNIAELRKV LDSKPSVLAL NIQRGDSTIY LLMQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..474] PSI-BLAST 104.0 Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.28251016030465 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.93232564230667 bayes_pls_golite062009
  • endopeptidase activity
    		•  4.76863192965644 bayes_pls_golite062009
  • hydrolase activity
    		•  4.7420645083083 bayes_pls_golite062009
  • serine hydrolase activity
    		•  3.40985043278892 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  3.40724860044542 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  3.13486560415684 bayes_pls_golite062009
  • catalytic activity
    		•  1.40927913545237 bayes_pls_golite062009
  • protein binding
    		•  0.0013332686405948 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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