YRC Public Data Repository - Protein Structure Prediction

Protein:	EG10463
Organism:	Escherichia coli str. K-12 substr. MG1655
Length:	474 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EG10463.

Description	E-value	Query Range	Subject Range
gi\|62126412, gi\|... - gi\|62178779\|ref\|YP_215196.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Choler...	401.0	[0..1]	[474..4]
gi\|74474903 - gi\|74474903\|dbj\|BAE44436.1\| antigenic protein Et 49 [Edwardsiella tarda]	386.0	[0..1]	[474..1]
gi\|227884924, gi... - gi\|227884924\|ref\|ZP_04002729.1\| serine endoprotease [Escherichia coli 83972], gi\|227838062\|gb\|EEJ485... gi\|218363873, gi... - gi\|218557104\|ref\|YP_002390017.1\| serine endoprotease [Escherichia coli S88], gi\|218363873\|emb\|CAR015... gi\|218425602, gi... - gi\|218688038\|ref\|YP_002396250.1\| serine endoprotease [Escherichia coli ED1a], gi\|218425602\|emb\|CAR06... gi\|115511572, gi... - gi\|117622448\|ref\|YP_851361.1\| serine endoprotease [Escherichia coli APEC O1], gi\|115511572\|gb\|ABI996... gi\|215263396, gi... - gi\|215485324\|ref\|YP_002327755.1\| serine endoprotease [Escherichia coli O127:H6 str. E2348/69], gi\|21... gi\|237704322, gi... - gi\|237704322\|ref\|ZP_04534803.1\| serine endoprotease [Escherichia sp. 3_2_53FAA], gi\|226902234\|gb\|EEH... gi\|26106505, gi\|... - gi\|26246108\|ref\|NP_752147.1\| serine endoprotease [Escherichia coli CFT073], gi\|26106505\|gb\|AAN78691.... gi\|91070806, gi\|... - gi\|91209232\|ref\|YP_539218.1\| serine endoprotease [Escherichia coli UTI89], gi\|91070806\|gb\|ABE05687.1...	385.0	[0..1]	[474..1]
gi\|110640382, gi... - gi\|110640382\|ref\|YP_668110.1\| serine endoprotease [Escherichia coli 536], gi\|110341974\|gb\|ABG68211.1... gi\|218698582, gi... - gi\|218698582\|ref\|YP_002406211.1\| serine endoprotease [Escherichia coli IAI39], gi\|218368568\|emb\|CAR1... gi\|190906963, gi... - gi\|75240248\|ref\|ZP_00724195.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|170680398, gi... - gi\|170680398\|ref\|YP_001742290.1\| protease Do [Escherichia coli SMS-3-5], gi\|170518116\|gb\|ACB16294.1\|...	385.0	[0..1]	[474..1]
gi\|193063170, gi... - gi\|75258848\|ref\|ZP_00730238.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|218552742, gi... - gi\|218552742\|ref\|YP_002385655.1\| serine endoprotease [Escherichia coli IAI1], gi\|218359510\|emb\|CAQ97... gi\|193067748, gi... - gi\|75238866\|ref\|ZP_00722848.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|218693627, gi... - gi\|218693627\|ref\|YP_002401294.1\| serine endoprotease [Escherichia coli 55989], gi\|218350359\|emb\|CAU9... gi\|194413698, gi... - gi\|75210486\|ref\|ZP_00710637.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|75194373, gi\|... - gi\|75194373\|ref\|ZP_00704443.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai... gi\|209917353, gi... - gi\|209917353\|ref\|YP_002291437.1\| serine endoprotease [Escherichia coli SE11], gi\|209910612\|dbj\|BAG75... gi\|75189258, gi\|... - gi\|75189258\|ref\|ZP_00702525.1\| COG0265: Trypsin-like serine proteases, typically periplasmic, contai...	384.0	[0..1]	[474..1]
gi\|168263926, gi... - gi\|205347433\|gb\|EDZ34064.1\| protease Do [Salmonella enterica subsp. enterica serovar Hadar str. RI_0... gi\|168464230, gi... - gi\|195632563\|gb\|EDX51017.1\| protease Do [Salmonella enterica subsp. enterica serovar Newport str. SL... gi\|194450352, gi... - gi\|194450352\|ref\|YP_002044199.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar He... gi\|194470491, gi... - gi\|194470491\|ref\|ZP_03076475.1\| protease Do [Salmonella enterica subsp. enterica serovar Kentucky st... gi\|205331307, gi... - gi\|205331307\|gb\|EDZ18071.1\| protease Do [Salmonella enterica subsp. enterica serovar 4,[5],12:i:- st... DEGP_SALTY - Periplasmic serine endoprotease DegP OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)... gi\|168230515, gi... - gi\|205335030\|gb\|EDZ21794.1\| protease Do [Salmonella enterica subsp. enterica serovar Kentucky str. C... DEGP_SALTY - Periplasmic serine endoprotease DegP OS=Salmonella typhimurium GN=degP PE=3 SV=1 gi\|168234985, gi... - gi\|197291665\|gb\|EDY31015.1\| protease Do [Salmonella enterica subsp. enterica serovar Schwarzengrund ... gi\|168245062, gi... - gi\|205336160\|gb\|EDZ22924.1\| protease Do [Salmonella enterica subsp. enterica serovar Heidelberg str.... gi\|238911275 - gi\|238911275\|ref\|ZP_04655112.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Ten... gi\|161361941, gi... - gi\|161612577\|ref\|YP_001586542.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Pa... gi\|167550586, gi... - gi\|205324436\|gb\|EDZ12275.1\| protease Do [Salmonella enterica subsp. enterica serovar Saintpaul str. ... lcl\|NC_016856.1_... - [gene=htrA] [protein=serine endoprotease] [protein_id=YP_005235880.1] [location=245196..246623] gi\|56412482, gi\|... - gi\|56412482\|ref\|YP_149557.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Paraty... DEGP_SALTY - Protease do OS=Salmonella typhimurium GN=degP PE=2 SV=1 gi\|199605795, gi... - gi\|200388697\|ref\|ZP_03215309.1\| protease Do [Salmonella enterica subsp. enterica serovar Virchow str... gi\|204926696, gi... - gi\|204926696\|ref\|ZP_03217898.1\| protease Do [Salmonella enterica subsp. enterica serovar Javiana str... gi\|205271327, gi... - gi\|205351546\|ref\|YP_002225347.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Ga... gi\|206707528, gi... - gi\|207855725\|ref\|YP_002242376.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar En... gi\|194712147, gi... - gi\|194736645\|ref\|YP_002113231.1\| protease Do [Salmonella enterica subsp. enterica serovar Schwarzeng... gi\|197265721, gi... - gi\|197265721\|ref\|ZP_03165795.1\| protease Do [Salmonella enterica subsp. enterica serovar Saintpaul s... gi\|197361417, gi... - gi\|197361417\|ref\|YP_002141053.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Pa... gi\|197940718, gi... - gi\|198246202\|ref\|YP_002214169.1\| protease Do [Salmonella enterica subsp. enterica serovar Dublin str...	383.0	[0..1]	[474..1]
gi\|25305541, gi\|... - gi\|25305541\|pir\|\|AC0528 protease DO precursor, heat shock protein HtrA [imported] - Salmonella enter... gi\|29140750, gi\|... - gi\|29140750\|ref\|NP_804092.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typhi ... gi\|213051748 - gi\|213051748\|ref\|ZP_03344626.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ... gi\|16759200 - gi\|16759200\|ref\|NP_454817.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typhi ... gi\|213425935 - gi\|213425935\|ref\|ZP_03358685.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ... gi\|213852252 - gi\|213852252\|ref\|ZP_03381784.1\| serine endoprotease [Salmonella enterica subsp. enterica serovar Typ...	383.0	[0..1]	[474..1]
gi\|110804216, gi... - gi\|110804216\|ref\|YP_687736.1\| serine endoprotease [Shigella flexneri 5 str. 8401], gi\|110613764\|gb\|A... gi\|30039963, gi\|... - gi\|30061721\|ref\|NP_835892.1\| serine endoprotease [Shigella flexneri 2a str. 2457T], gi\|30039963\|gb\|A... gi\|24050365, gi\|... - gi\|24111599\|ref\|NP_706109.1\| serine endoprotease [Shigella flexneri 2a str. 301], gi\|24050365\|gb\|AAN...	383.0	[0..1]	[474..1]
gi\|59712832, gi\|... - gi\|59712832\|ref\|YP_205608.1\| serine endoprotease DegP (protease Do), periplasmic [Vibrio fischeri ES...	382.0	[0..1]	[474..1]
gi\|81239700, gi\|... - gi\|82775552\|ref\|YP_401899.1\| serine endoprotease [Shigella dysenteriae Sd197], gi\|81239700\|gb\|ABB604...	382.0	[0..1]	[474..1]

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Predicted Domain #1

Region A:
Residues: [1-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKTTLALSA LALSLGLALS PLSATAAETS SATTAQQMPS LAPMLEKVMP SVVSINVEGS  60
   61 TTVNTPRMPR NFQQFFGDDS PFCQEGSPFQ SSPFCQGGQG GNGGGQQQKF MALGSGVIID 120
  121 ADKGYVVTNN HVVDNATVIK VQLSDGRKFD AKMVGKDPRS DIALIQIQNP KNLTAIKMAD 180
  181 SDALRVGDYT VAIGNPFGLG ETVTSGIVSA LGRSGLNAEN YENFIQTDAA INRGNSGGAL 240
  241 VNLNGELIGI NTAILAPDGG NIGIGFAIPS NMVKNLTSQM VEYGQVKRGE LGIMGTELNS 300
  301 ELAKAMKVDA QRGAFVSQVL PNSSAAKAGI KAGDVITSLN GKPISSFAAL RAQVGTMPVG 360
  361 SKLTLGLLRD GKQVNVNLEL QQSSQNQVDS SSIFNGIEGA EMSNKGKDQG VVVNNVKTGT 420
  421 PAAQIGLKKG DVIIGANQQA VKNIAELRKV LDSKPSVLAL NIQRGDSTIY LLMQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	104.0
Match:	1ky9A
Description:	Protease Do (DegP, HtrA), C-terminal domains; Protease Do (DegP, HtrA), catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	5.28251016030465	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	4.93232564230667	bayes_pls_golite062009
endopeptidase activity	4.76863192965644	bayes_pls_golite062009
hydrolase activity	4.7420645083083	bayes_pls_golite062009
serine hydrolase activity	3.40985043278892	bayes_pls_golite062009
serine-type peptidase activity	3.40724860044542	bayes_pls_golite062009
serine-type endopeptidase activity	3.13486560415684	bayes_pls_golite062009
catalytic activity	1.40927913545237	bayes_pls_golite062009
protein binding	0.0013332686405948	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: