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Protein Overview: EG10201

General Information:
Name(s) found: dacA / EG10201 [EcoGene]
Description(s) found:
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  • D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) / D-alanine D-alanine carboxypeptidase PBP5, cell morphology; penicillin-binding protein 5; beta-lactamase activity [EcoGene]
  • D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) [Escherichia coli K12] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5) [Escherichia coli str. K-12 substr. MG1655] [Ecoli-contam-Dam1-Mind-COMA-MBP-110.fasta]
    • Organism: Escherichia coli str. K-12 substr. MG1655
    Length: 403 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDALink to PubMed article]
    Biological Process: cell division [IGILink to PubMed article]
    regulation of cell shape [IEA][IGILink to PubMed article]
    cellular cell wall macromolecule metabolic process [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    peptidoglycan metabolic process [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    peptidoglycan biosynthetic process [IEA]
    proteolysis [IEA]
    Molecular Function: carboxypeptidase activity [IDALink to PubMed article][IMPLink to PubMed article]
    protein binding [IPILink to PubMed article]
    serine-type D-Ala-D-Ala carboxypeptidase activity [IDALink to PubMed articleLink to PubMed article][IEA][IMPLink to PubMed article]
    penicillin binding [IDALink to PubMed article]
    beta-lactamase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTIFSARIM KRLALTTALC TAFISAAHAD DLNIKTMIPG VPQIDAESYI LIDYNSGKVL  60
   61 AEQNADVRRD PASLTKMMTS YVIGQAMKAG KFKETDLVTI GNDAWATGNP VFKGSSLMFL 120
  121 KPGMQVPVSQ LIRGINLQSG NDACVAMADF AAGSQDAFVG LMNSYVNALG LKNTHFQTVH 180
  181 GLDADGQYSS ARDMALIGQA LIRDVPNEYS IYKEKEFTFN GIRQLNRNGL LWDNSLNVDG 240
  241 IKTGHTDKAG YNLVASATEG QMRLISAVMG GRTFKGREAE SKKLLTWGFR FFETVNPLKV 300
  301 GKEFASEPVW FGDSDRASLG VDKDVYLTIP RGRMKDLKAS YVLNSSELHA PLQKNQVVGT 360
  361 INFQLDGKTI EQRPLVVLQE IPEGNFFGKI IDYIKLMFHH WFG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..403] PSI-BLAST 104.0 The crystal structure of wild type penicillin-binding protein 5 from E. coli

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • drug binding
    		•  3.43867028493374 bayes_pls_golite062009
  • peptidase activity
    		•  3.14503902416546 bayes_pls_golite062009
  • serine-type D-Ala-D-Ala carboxypeptidase activity
    		•  3.12650314537616 bayes_pls_golite062009
  • penicillin binding
    		•  2.89507018520983 bayes_pls_golite062009
  • hydrolase activity
    		•  2.80171403488139 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.78480589579188 bayes_pls_golite062009
  • serine-type carboxypeptidase activity
    		•  2.70174066798582 bayes_pls_golite062009
  • serine-type exopeptidase activity
    		•  2.69091897402517 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  1.96547160092829 bayes_pls_golite062009
  • catalytic activity
    		•  1.85492008367309 bayes_pls_golite062009
  • serine hydrolase activity
    		•  1.69122379434116 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  1.6885532900392 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.24775184094433 bayes_pls_golite062009
  • binding
    		•  1.11566650386305 bayes_pls_golite062009
  • protein binding
    		•  0.0666688846338231 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle