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Protein Overview: KU80_ARATH

General Information:
Name(s) found: KU80_ARATH [Swiss-Prot]
Description(s) found:
Found 8 descriptions.
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  • ATP-dependent DNA helicase 2 subunit KU80 OS=Arabidopsis thaliana GN=KU80 PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 680 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: DNA repair [TAS]
    response to heat [IEP]
    DNA integration [TAS]
    telomere maintenance [TAS]
    double-strand break repair via nonhomologous end joining [TAS]
    double-strand break repair [IMP]
    Molecular Function: protein binding [IPI]
    double-stranded DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARNREGLVL VLDVGPAMRS VLPDVEKACS MLLQKKLIYN KYDEVGIVVF GTEETGNELA  60
   61 REIGGYENVT VLRNIRVVDE LAAEHVKQLP RGTVAGDFLD ALIVGMDMLI KMYGNAHKGK 120
  121 KRMCLITNAA CPTKDPFEGT KDDQVSTIAM KMAAEGIKME SIVMRSNLSG DAHERVIEEN 180
  181 DHLLTLFSSN AIAKTVNVDS PLSLLGSLKT RRVAPVTLFR GDLEINPTMK IKVWVYKKVA 240
  241 EERLPTLKMY SDKAPPTDKF AKHEVKVDYD YKVTAESTEV IAPEERIKGF RYGPQVIPIS 300
  301 PDQIETLKFK TDKGMKLLGF TEASNILRHY YMKDVNIVVP DPSKEKSVLA VSAIAREMKE 360
  361 TNKVAIVRCV WRNGQGNVVV GVLTPNVSER DDTPDSFYFN VLPFAEDVRE FPFPSFNKLP 420
  421 SSWKPDEQQQ AVADNLVKML DLAPSAEEEV LKPDLTPNPV LQRFYEYLEL KSKSTDATLP 480
  481 PMDGTFKRLM EQDPELSSNN KSIMDTFRGS FEVKENPKLK KASKRLLRDK PSGSDDEDNR 540
  541 MITYDAKENK IDIVGDANPI QDFEAMISRR DKTDWTEKAI TQMKNLIMKL VENCTDEGDK 600
  601 ALECVLALRK GCVLEQEPKQ FNEFLNHLFK LCQERNLSHL LEHFMSKKIT LIPKSEAADS 660
  661 DIVDENAGDF IVKQESMLES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..530] PSI-BLAST 102.0 Ku80 subunit
    2 View Details [531..680] PSI-BLAST 45.30103 Three-dimensional structure of Ku80 CTD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • double-stranded telomeric DNA binding
    		•  8.29108426371603 bayes_pls_golite062009
  • telomeric DNA binding
    		•  5.16364366157397 bayes_pls_golite062009
  • binding
    		•  2.75824485094584 bayes_pls_golite062009
  • protein binding
    		•  2.58357303743968 bayes_pls_golite062009
  • promoter binding
    		•  2.1752902301709 bayes_pls_golite062009
  • transcription activator activity
    		•  1.52393053398849 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.27592771659837 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.985753648509262 bayes_pls_golite062009
  • protein complex binding
    		•  0.94234534987624 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.814975395718076 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.73404855126602 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.720743494912414 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.655463239522058 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.64812784969409 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.506640285146188 bayes_pls_golite062009
  • DNA binding
    		•  0.496246846559375 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.450760554291027 bayes_pls_golite062009
  • receptor binding
    		•  0.234020194580985 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.233577421367532 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.15516806759612 bayes_pls_golite062009
  • identical protein binding
    		•  0.125363466534611 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle