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View Structure Prediction Details

Protein: KU80_ARATH
Organism: Arabidopsis thaliana
Length: 680 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KU80_ARATH.

Description E-value Query
Range
Subject
Range
gi|12323098 - gi|12323098|gb|AAG51535.1|AC051631_15 hypothetical protein; 39910-36975 [Arabidopsis thaliana]
626.0 [0..18] [680..1]

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Predicted Domain #1
Region A:
Residues: [1-530]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARNREGLVL VLDVGPAMRS VLPDVEKACS MLLQKKLIYN KYDEVGIVVF GTEETGNELA  60
   61 REIGGYENVT VLRNIRVVDE LAAEHVKQLP RGTVAGDFLD ALIVGMDMLI KMYGNAHKGK 120
  121 KRMCLITNAA CPTKDPFEGT KDDQVSTIAM KMAAEGIKME SIVMRSNLSG DAHERVIEEN 180
  181 DHLLTLFSSN AIAKTVNVDS PLSLLGSLKT RRVAPVTLFR GDLEINPTMK IKVWVYKKVA 240
  241 EERLPTLKMY SDKAPPTDKF AKHEVKVDYD YKVTAESTEV IAPEERIKGF RYGPQVIPIS 300
  301 PDQIETLKFK TDKGMKLLGF TEASNILRHY YMKDVNIVVP DPSKEKSVLA VSAIAREMKE 360
  361 TNKVAIVRCV WRNGQGNVVV GVLTPNVSER DDTPDSFYFN VLPFAEDVRE FPFPSFNKLP 420
  421 SSWKPDEQQQ AVADNLVKML DLAPSAEEEV LKPDLTPNPV LQRFYEYLEL KSKSTDATLP 480
  481 PMDGTFKRLM EQDPELSSNN KSIMDTFRGS FEVKENPKLK KASKRLLRDK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 102.0
Match: 1jeqB
Description: Ku80 subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
double-stranded telomeric DNA binding 8.29108426371603 bayes_pls_golite062009
telomeric DNA binding 5.16364366157397 bayes_pls_golite062009
binding 2.75824485094584 bayes_pls_golite062009
protein binding 2.58357303743968 bayes_pls_golite062009
promoter binding 2.1752902301709 bayes_pls_golite062009
transcription activator activity 1.52393053398849 bayes_pls_golite062009
transcription regulator activity 1.27592771659837 bayes_pls_golite062009
DNA-dependent ATPase activity 0.985753648509262 bayes_pls_golite062009
protein complex binding 0.94234534987624 bayes_pls_golite062009
single-stranded DNA binding 0.814975395718076 bayes_pls_golite062009
protein dimerization activity 0.73404855126602 bayes_pls_golite062009
DNA helicase activity 0.720743494912414 bayes_pls_golite062009
nucleic acid binding 0.655463239522058 bayes_pls_golite062009
protein heterodimerization activity 0.64812784969409 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.506640285146188 bayes_pls_golite062009
DNA binding 0.496246846559375 bayes_pls_golite062009
structure-specific DNA binding 0.450760554291027 bayes_pls_golite062009
receptor binding 0.234020194580985 bayes_pls_golite062009
transcription repressor activity 0.233577421367532 bayes_pls_golite062009
protein C-terminus binding 0.15516806759612 bayes_pls_golite062009
identical protein binding 0.125363466534611 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [531-680]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSGSDDEDNR MITYDAKENK IDIVGDANPI QDFEAMISRR DKTDWTEKAI TQMKNLIMKL  60
   61 VENCTDEGDK ALECVLALRK GCVLEQEPKQ FNEFLNHLFK LCQERNLSHL LEHFMSKKIT 120
  121 LIPKSEAADS DIVDENAGDF IVKQESMLES 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.30103
Match: 1rw2A
Description: Three-dimensional structure of Ku80 CTD
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle