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Protein Overview: nhr-64

General Information:
Name(s) found: nhr-64 / CE39697 [WormBase]
Description(s) found:
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  • WBGene00003654 locus:nhr-64 Nuclear hormone receptor family member nhr-64 status:Confirmed UniProt:O44960 protein_id:CCD67353.1 [WormBase]
  • gi|28396030|gb|AAO39178.1| nuclear receptor NHR-64 [Caenorhabditis elegans] [NCBI NR]
  • gi|115532043|ref|NP_001021043.2| Nuclear Hormone Receptor family member (nhr-64) [Caenorhabditis elegans] [NCBI NR]
  • nuclear receptor NHR-64 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE39697 WBGene00003654 locus:nhr-64 status:Confirmed UniProt:O44960 protein_id:AAT27251.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE39697 WBGene00003654 locus:nhr-64 status:Confirmed UniProt:O44960 protein_id:AAT27251.1| [wormORF-contam.fasta]
  • CE39697 WBGene00003654 locus:nhr-64 status:Confirmed SW:O44960 protein_id:AAT27251.1 [wormpep160-contam.fasta]
  • Nuclear Hormone Receptor family member (nhr-64) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE39697 WBGene00003654 locus:nhr-64 status:Confirmed [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE39697 WBGene00003654 locus:nhr-64 status:Confirmed UniProt:O44960 protein_id:CCD67353.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE39697 WBGene00003654 locus:nhr-64 status:Confirmed UniProt:O44960 protein_id:CCD67353.1 Nuclear hormone receptor family member nhr-64 [wormpep246-ecoli-contam.fasta]
  • Isoform of O44960, Isoform b of Nuclear hormone receptor family member nhr-64 OS=Caenorhabditis elegans GN=nhr-64 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 344 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLEEKEEVS TSTSQSPQSS SFENVFCAIC GDRATGKHYG AMSCDGCKAK RNSCRKCRFD  60
   61 VCLRKGMRRD AVQTERDRIR PANPLSNGSN GGIVPDDPLL DTLIRAEAST RGLRTTVITK 120
  121 TAEARKQATT NDVTDSMNQQ LTLMVEWAKV LEGFQRVDNI TQVALLRHFS AQHLVMCAAF 180
  181 RSIHLSDAVW LTNETCLHKD SPKIPDMNRV AERIIDQVTN PMRSLHMNEI EYIALKAIAF 240
  241 FDPLAKGITS ESYSDVEEMR QRILESFERH VRYVSPYKDM PLRFANLLLL LPPMLAISRD 300
  301 LVEDVQLAKL FGLASIDNLM LELMLPNEGK NTTDKTSPPI MCHQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] FFAS03 3.95 Orphan nuclear receptor reverb
    2 View Details [86..344] PSI-BLAST 50.69897 LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.84932768708444 bayes_pls_golite062009
  • DNA binding
    		•  3.45124926204188 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.34875987514951 bayes_pls_golite062009
  • binding
    		•  2.8684204787273 bayes_pls_golite062009
  • transcription activator activity
    		•  2.7888666510808 bayes_pls_golite062009
  • transcription factor activity
    		•  2.74592237402384 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.5486735958299 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.41415369932937 bayes_pls_golite062009
  • protein binding
    		•  2.35367391992524 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.23212813739998 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.83119162033863 bayes_pls_golite062009
  • transcription factor binding
    		•  1.22761682002 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.1269808729848 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.02819346233483 bayes_pls_golite062009
  • transporter activity
    		•  0.777447304729872 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.548821113052527 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.51780579506502 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.514152028118082 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.449959641856445 bayes_pls_golite062009
  • structural molecule activity
    		•  0.366127650337533 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.196227315276875 bayes_pls_golite062009
  • catalytic activity
    		•  0.133319360419662 bayes_pls_golite062009
  • receptor activity
    		•  0.0887087342257975 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.83878598697109 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription activator binding
    		•  2.98235973123409 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • receptor activity
    		•  2.62895787183554 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  2.30195937604451 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.27959329058894 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • signal transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.60419100774741 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.59968001933699 bayes_pls_golite062009
  • retinoid binding
    		•  1.57244905045132 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.45798199211445 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.45560845709347 bayes_pls_golite062009
  • ecdysteroid hormone receptor activity
    		•  1.42190666652857 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • promoter binding
    		•  1.28787959668198 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  1.23181585568439 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.995333369475571 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.95284349923679 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.47826452126899 bayes_pls_golite062009
  • lipid binding
    		•  0.475303782949439 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.42652610679613 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle