YRC Public Data Repository - Protein Structure Prediction

Protein:	PWP2
Organism:	Homo sapiens
Length:	919 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PWP2.

Description	E-value	Query Range	Subject Range
gi\|148658115, gi... - gi\|148658115\|ref\|YP_001278320.1\| NB-ARC domain-containing protein [Roseiflexus sp. RS-1], gi\|1485702...	0.0	[2..813]	[767..1521]
gi\|186464325, gi... - gi\|23128981\|ref\|ZP_00110817.1\| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi\|18668187...	0.0	[6..673]	[1164..1786]
YY46_NOSS1 - Uncharacterized WD repeat-containing protein alr3466 OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=... gi\|25530855 - pir\|\|AC2239 WD-40 repeat protein [imported] - Nostoc sp. (strain PCC 7120)	0.0	[3..656]	[895..1503]
gi\|75701503, gi\|... - gi\|75907778\|ref\|YP_322074.1\| ribosome assembly protein 4 (RSA4) [Anabaena variabilis ATCC 29413], gi...	0.0	[5..656]	[1035..1639]
gi\|37523925, gi\|... - gi\|37523925\|ref\|NP_927302.1\| WD repeat-containing protein [Gloeobacter violaceus PCC 7421], gi\|35214...	0.0	[15..656]	[569..1166]
gi\|115443476, gi... - gi\|115443476\|ref\|XP_001218545.1\| hypothetical protein ATEG_09923 [Aspergillus terreus NIH2624], gi\|1...	0.0	[6..673]	[640..1243]

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Predicted Domain #1

Region A:
Residues: [1-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFAYRFSNL LGTVYRRGNL NFTCDGNSVI SPVGNRVTVF DLKNNKSDTL PLATRYNVKC  60
   61 VGLSPDGRLA IIVDEGGDAL LVSLVCRSVL HHFHFKGSVH SVSFSPDGRK FVVTKGNIAQ 120
  121 MYHAPGKKRE FNAFVLDKTY FGPYDETTCI DWTDDSRCFV VGSKDMSTWV FGAERWDNLI 180
  181 YYALGGHKDA IVACFFESNS LDLYSLSQDG VLCMWQCDTP PEGLRLKPPA GWKADLLQRE 240
  241 EEEEEEEDQE GDRETTIRGK ATPAEEEKTG KVKYSRLAKY FFNKEGDFNN LTAAAFHKKS 300
  301 HLLVTGFASG IFHLHELPE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.0
Match:	1vyhC
Description:	PAF-AH Holoenzyme: Lis1/Alfa2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
	6.67009948605948	bayes_pls_golite062009
snoRNA binding	6.03079504484743	bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific)	4.71992275913384	bayes_pls_golite062009
actin binding	3.86142918698875	bayes_pls_golite062009
RNA binding	3.77273677738815	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.25521258308263	bayes_pls_golite062009
cytoskeletal protein binding	3.1056443224755	bayes_pls_golite062009
tubulin binding	2.76945430061825	bayes_pls_golite062009
microtubule binding	2.72684103222924	bayes_pls_golite062009
dynein binding	2.54821997913979	bayes_pls_golite062009
binding	2.42570478946173	bayes_pls_golite062009
protein binding	2.26925404328312	bayes_pls_golite062009
actin filament binding	2.0735069176589	bayes_pls_golite062009
histone methyltransferase activity	1.85632145559025	bayes_pls_golite062009
dynactin binding	1.85146647785657	bayes_pls_golite062009
transporter activity	1.65168247201205	bayes_pls_golite062009
structural molecule activity	1.47097979074281	bayes_pls_golite062009
transcription regulator activity	1.42548927439572	bayes_pls_golite062009
protein methyltransferase activity	1.35170368882651	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.22384651674093	bayes_pls_golite062009
nucleic acid binding	1.20712373307552	bayes_pls_golite062009
lysine N-methyltransferase activity	1.15313682561559	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	1.15313682561559	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	1.15313682561559	bayes_pls_golite062009
mRNA binding	1.05053985350578	bayes_pls_golite062009
microtubule plus-end binding	1.01166033978052	bayes_pls_golite062009
myosin binding	0.989691178611801	bayes_pls_golite062009
DNA binding	0.963493426709289	bayes_pls_golite062009
kinase activity	0.807669232329985	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.805273887494167	bayes_pls_golite062009
histone binding	0.685319917508843	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.634547834947756	bayes_pls_golite062009
protein kinase activity	0.544118712921054	bayes_pls_golite062009
dynein intermediate chain binding	0.443846546939402	bayes_pls_golite062009
transcription factor activity	0.435575551078191	bayes_pls_golite062009
molecular transducer activity	0.367729389382533	bayes_pls_golite062009
signal transducer activity	0.367729389382533	bayes_pls_golite062009
myosin II binding	0.33142771724387	bayes_pls_golite062009
transcription repressor activity	0.298055197418849	bayes_pls_golite062009
ligase activity	0.20682813699621	bayes_pls_golite062009
transcription factor binding	0.136928257321035	bayes_pls_golite062009
substrate-specific transporter activity	0.121183207943714	bayes_pls_golite062009
structural constituent of cytoskeleton	0.118975415284669	bayes_pls_golite062009
protein serine/threonine kinase activity	0.0803897416817422	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.00585398682921312	bayes_pls_golite062009
N-methyltransferase activity	0.00335766408304172	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [320-455]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNLIHSLSIS DQSIASVAIN SSGDWIAFGC SGLGQLLVWE WQSESYVLKQ QGHFNSMVAL  60
   61 AYSPDGQYIV TGGDDGKVKV WNTLSGFCFV TFTEHSSGVT GVTFTATGYV VVTSSMDGTV 120
  121 RAFDLHRYRN FRTFTS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	5.54
Match:	2gnqA
Description:	No description for 2gnqA was found.

Predicted Domain #3

Region A:
Residues: [456-522]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRPTQFSCVA VDASGEIVSA GAQDSFEIFV WSMQTGRLLD VLSGHEGPIS GLCFNPMKSV  60
   61 LASASWD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.522879
Match:	2gnqA
Description:	No description for 2gnqA was found.

Predicted Domain #4

Region A:
Residues: [523-812]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTVRLWDMFD SWRTKETLAL TSDALAVTFR PDGAELAVAT LNSQITFWDP ENAVQTGSIE  60
   61 GRHDLKTGRK ELDKITAKHA AKGKAFTALC YSADGHSILA GGMSKFVCIY HVREQILMKR 120
  121 FEISCNLSLD AMEEFLNRRK MTEFGNLALI DQDAGQEDGV AIPLPGVRKG DMSSRHFKPE 180
  181 IRVTSLRFSP TGRCWAATTT EGLLIYSLDT RVLFDPFELD TSVTPGRVRE ALRQQDFTRA 240
  241 ILMALRLNES KLVQEALEAV PRGEIEVVTS SLPELYVEKV LEFLASSFEV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.39794
Match:	2oitA
Description:	No description for 2oitA was found.

Predicted Domain #5

Region A:
Residues: [813-919]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRHLEFYLLW THKLLMLHGQ KLKSRAGTLL PVIQFLQKSI QRHLDDLSKL CSWNHYNMQY  60
   61 ALAVSKQRGT KRSLDPLGSE EEAEASEDDS LHLLGGGGRD SEEEMLA

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	21.920819
Match:	PF04047.5
Description:	No description for PF04047.5 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: