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View Structure Prediction Details

Protein: sv-PC
Organism: Drosophila melanogaster
Length: 647 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sv-PC.

Description E-value Query
Range
Subject
Range
sv-PD - The gene shaven is referred to in FlyBase by the symbol Dmel\sv (CG11049, FBgn0005561). It is a prot...
427.0 [0..1] [647..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIMDIQTST HHIHGLGTHE LQHRILHPHI LHSTQEETLN TSTGQLEHDS QHLQQHHLTH  60
   61 HQQQDVSPTL HNLQNTRTGD SLSTTINTNQ NQHGHQHLSG SNMYTSSQME DKSKANKYDE 120
  121 YSSRTLSNIS DANTTPSANN FITQSQGIEW ITAMNDIQNG A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDSHSSQGSI SGDGHGGVNQ LGGVFVNGRP LPDVVRQRIV ELAHNGVRPC DISRQLRVSH  60
   61 GCVSKILSRY YETGSFKAGV IGGSKPKVAT PPVVDAIANY KRENPTMFAW EIRDRLLAEA 120
  121 ICSQDNVPSV SSINRIVRNK AAEKAKHV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.0
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [310-427]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHHQQHHVSQ SLGGGHIATE SVDSSTGTIG EPQPPTSNSS ANSVNTNVSA SASVHASIPT  60
   61 SGTDSVQVSV GHINANSNET THINSTAEQR TTGYSINGIL GIQHGHHSHN NNNNSSVN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.08
Match: 2apoA
Description: Crystal Structure of the Methanococcus jannaschii Cbf5 Nop10 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.32498104079149 bayes_pls_golite062009
nucleic acid binding 2.0340444056235 bayes_pls_golite062009
DNA binding 1.96520460315172 bayes_pls_golite062009
pseudouridine synthase activity 1.95827425471645 bayes_pls_golite062009
catalytic activity 1.86133205308688 bayes_pls_golite062009
binding 1.39195733615426 bayes_pls_golite062009
transcription activator activity 1.27714242179739 bayes_pls_golite062009
protein binding 1.14602657647498 bayes_pls_golite062009
intramolecular transferase activity 0.667162168337187 bayes_pls_golite062009
isomerase activity 0.567803132409133 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [428-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNNNTESSCK RKRIEAHDEN HDTNIHSDND DGKRQRMSTY SGDQLYTNIW SGKWCIKDDH  60
   61 KLLAELGNLT ASTGNCPATY YEASNGFSTT PISGSGATAS GNDTSMLYDS ITTISQTQSS 120
  121 IYTPAIGPSI GCSSVVPGSD YAYNPAYTQY GGAYGSYGYG TGSGLINSSY YYESGQTQSP 180
  181 LTHDLRSPLV ATRANSLASA ASPGSGSACT KSESSDIFLA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle