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View Structure Prediction Details

Protein: sv-PC
Organism: Drosophila melanogaster
Length: 647 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sv-PC.

Description E-value Query
Range
Subject
Range
sv-PD - The gene shaven is referred to in FlyBase by the symbol Dmel\sv (CG11049, FBgn0005561). It is a prot...
427.0 [0..1] [647..1]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIMDIQTST HHIHGLGTHE LQHRILHPHI LHSTQEETLN TSTGQLEHDS QHLQQHHLTH  60
   61 HQQQDVSPTL HNLQNTRTGD SLSTTINTNQ NQHGHQHLSG SNMYTSSQME DKSKANKYDE 120
  121 YSSRTLSNIS DANTTPSANN FITQSQGIEW ITAMNDIQNG A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [162-309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDSHSSQGSI SGDGHGGVNQ LGGVFVNGRP LPDVVRQRIV ELAHNGVRPC DISRQLRVSH  60
   61 GCVSKILSRY YETGSFKAGV IGGSKPKVAT PPVVDAIANY KRENPTMFAW EIRDRLLAEA 120
  121 ICSQDNVPSV SSINRIVRNK AAEKAKHV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.0
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [310-427]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHHQQHHVSQ SLGGGHIATE SVDSSTGTIG EPQPPTSNSS ANSVNTNVSA SASVHASIPT  60
   61 SGTDSVQVSV GHINANSNET THINSTAEQR TTGYSINGIL GIQHGHHSHN NNNNSSVN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.08
Match: 2apoA
Description: Crystal Structure of the Methanococcus jannaschii Cbf5 Nop10 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.32498104079149 bayes_pls_golite062009
nucleic acid binding 2.0340444056235 bayes_pls_golite062009
DNA binding 1.96520460315172 bayes_pls_golite062009
pseudouridine synthase activity 1.95827425471645 bayes_pls_golite062009
catalytic activity 1.86133205308688 bayes_pls_golite062009
binding 1.39195733615426 bayes_pls_golite062009
transcription activator activity 1.27714242179739 bayes_pls_golite062009
protein binding 1.14602657647498 bayes_pls_golite062009
intramolecular transferase activity 0.667162168337187 bayes_pls_golite062009
isomerase activity 0.567803132409133 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [428-647]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNNNTESSCK RKRIEAHDEN HDTNIHSDND DGKRQRMSTY SGDQLYTNIW SGKWCIKDDH  60
   61 KLLAELGNLT ASTGNCPATY YEASNGFSTT PISGSGATAS GNDTSMLYDS ITTISQTQSS 120
  121 IYTPAIGPSI GCSSVVPGSD YAYNPAYTQY GGAYGSYGYG TGSGLINSSY YYESGQTQSP 180
  181 LTHDLRSPLV ATRANSLASA ASPGSGSACT KSESSDIFLA 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle