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View Structure Prediction Details

Protein: gi|74876832, gi|...
Organism: Drosophila melanogaster
Length: 924 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|74876832, gi|....

Description E-value Query
Range
Subject
Range
gi|45446812, gi|... - gi|45554224|ref|NP_996354.1| small conductance calcium-activated potassium channel, isoform F [Droso...
529.0 [0..1] [924..1]

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Predicted Domain #1
Region A:
Residues: [1-464]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIQKLNDTT NSGYVSSEET DSLLVSSSNP SKGGGRTALL RQVKSNSTNG PTTGASTSSS  60
   61 GSVSGGGGGS GSGGGSASGS AAGASKPTLM RQDRTSTYLT SPQQSQHARM GSEESMRGGA 120
  121 SGAAGHDEDV EQGLVRSSIV PDIEVHEEDQ EQHSQQLNAT TMATMTNNQQ QQQPTISIMN 180
  181 LSLKPGDSHS HSSSPGSHPN LGTSSYQNLA SSIPPSVPSR CRACRNCSRR ASTTPTTLID 240
  241 RSASRDSVKS AFQQGNLSGS MAICISNSAL PQQQQLQQQY HLQQQQQQHY QLQQHHLHQQ 300
  301 QLQQSQQQVP PVLITSSPTN GSRIIRQSSQ PESSSTAICC GPHSACVGHA HSHSHTVPNV 360
  361 SLKQLRESSG DGIAGIAADS LRINGGMRPF KQLRKPASTL SIPGSMKTPS IANREQISSG 420
  421 CNEEAAEALV GIHSDYPRYM EERALTGGNT SRKPSTNSAK HKPN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1y0fA
Description: No description for 1y0fA was found.

Predicted Domain #2
Region A:
Residues: [465-765]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGYRLGKRKA LFEKRKRISD YALVMGMFGI IVMVIENELS SAGVYTKASF YSTALKTLIS  60
   61 VSTVILLGLI VAYHALEVQL FMIDNCADDW RIAMTWQRIS QIGLELFICA IHPIPGEYYF 120
  121 QWTTKLANKN KTIGTEMVPY DVALSLPMFL RLYLICRVML LHSKLFTDAS SRSIGALNRI 180
  181 NFNTRFVLKT LMTICPGTVL LVFMVSLWII ASWTLRQCER FHDEEHANLL NSMWLTAITF 240
  241 LCVGYGDIVP NTYCGRGITL TCGMVGAGCT ALLVAVVSRK LELTRAEKHV HNFMMDTQLT 300
  301 K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1orqC
Description: Potassium channel KVAP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
voltage-gated potassium channel activity 12.0716262326447 bayes_pls_golite062009
potassium channel activity 12.0564503263181 bayes_pls_golite062009
voltage-gated cation channel activity 11.2479281243224 bayes_pls_golite062009
voltage-gated ion channel activity 11.0164314117387 bayes_pls_golite062009
voltage-gated channel activity 10.9923023836994 bayes_pls_golite062009
metal ion transmembrane transporter activity 9.85051068330727 bayes_pls_golite062009
cation channel activity 9.62064031772276 bayes_pls_golite062009
ion channel activity 8.91395130684665 bayes_pls_golite062009
gated channel activity 8.84587381436962 bayes_pls_golite062009
channel activity 8.68489845295557 bayes_pls_golite062009
passive transmembrane transporter activity 8.68489845295557 bayes_pls_golite062009
substrate-specific channel activity 8.67927944890782 bayes_pls_golite062009
ligand-gated ion channel activity 5.74511802205447 bayes_pls_golite062009
ligand-gated channel activity 5.74511802205447 bayes_pls_golite062009
cation transmembrane transporter activity 5.13805155650973 bayes_pls_golite062009
inward rectifier potassium channel activity 5.0997110076666 bayes_pls_golite062009
ion transmembrane transporter activity 5.04374327766634 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.64120459994573 bayes_pls_golite062009
transporter activity 2.93091397928047 bayes_pls_golite062009
transmembrane transporter activity 2.82224868778929 bayes_pls_golite062009
substrate-specific transporter activity 2.79688978937497 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [766-820]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLKNAAANVL RETWLIYKHT RLVKRVNPGR VRTHQRKFLL AIYALRKVKM DQRKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.69897
Match: 1kkdA
Description: Small-conductance potassium channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
potassium channel activity 12.9154216859515 bayes_pls_golite062009
metal ion transmembrane transporter activity 10.690117627191 bayes_pls_golite062009
cation channel activity 10.4729582700993 bayes_pls_golite062009
ion channel activity 9.76420146980976 bayes_pls_golite062009
gated channel activity 9.69845089208228 bayes_pls_golite062009
channel activity 9.53251272468341 bayes_pls_golite062009
passive transmembrane transporter activity 9.53251272468341 bayes_pls_golite062009
substrate-specific channel activity 9.52766364291262 bayes_pls_golite062009
cation transmembrane transporter activity 5.94944590079392 bayes_pls_golite062009
ion transmembrane transporter activity 5.84582254185274 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 5.42471865207378 bayes_pls_golite062009
calcium-activated potassium channel activity 4.85096783740785 bayes_pls_golite062009
ion gated channel activity 3.66857233866209 bayes_pls_golite062009
transporter activity 3.65156094985283 bayes_pls_golite062009
substrate-specific transporter activity 3.56349914685586 bayes_pls_golite062009
transmembrane transporter activity 3.5594499564237 bayes_pls_golite062009
small conductance calcium-activated potassium channel activity 3.44162773824006 bayes_pls_golite062009
calcium activated cation channel activity 3.35031790098165 bayes_pls_golite062009
protein binding 1.61033690476624 bayes_pls_golite062009
binding 1.32969330984971 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [821-924]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNANTITDM AKTQNTVYEI ISDMSSRQDA IEERLTNLED KMQSIQEHME SLPDLLSRCL  60
   61 TQHQERIEQR RNFLHPDTAA VAPIQAPTPQ SMFNAAPMLF PHSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle