YRC Public Data Repository - Protein Structure Prediction

Protein:	MUTS_YERPE
Organism:	Yersinia pestis
Length:	851 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MUTS_YERPE.

Description	E-value	Query Range	Subject Range
MUTS_ERWCT - DNA mismatch repair protein mutS OS=Erwinia carotovora subsp. atroseptica GN=mutS PE=3 SV=1 MUTS_PECAS - DNA mismatch repair protein MutS OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN...	0.0	[7..851]	[9..854]
MUTS_PHOLL - DNA mismatch repair protein mutS OS=Photorhabdus luminescens subsp. laumondii GN=mutS PE=3 SV=1 MUTS_PHOLL - DNA mismatch repair protein MutS OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CI...	0.0	[1..851]	[1..851]
gi\|77976003, gi\|... - gi\|77976003\|ref\|ZP_00831536.1\| COG0249: Mismatch repair ATPase (MutS family) [Yersinia frederiksenii...	0.0	[1..851]	[1..851]
MUTS_YERPS - DNA mismatch repair protein MutS OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=mutS ... MUTS_YERP3 - DNA mismatch repair protein MutS OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=m... MUTS_YERPS - DNA mismatch repair protein mutS OS=Yersinia pseudotuberculosis GN=mutS PE=3 SV=1 MUTS_YERPB - DNA mismatch repair protein MutS OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=mutS P...	0.0	[1..851]	[1..851]
gi\|238784154, gi... - gi\|77958743\|ref\|ZP_00822772.1\| COG0249: Mismatch repair ATPase (MutS family) [Yersinia bercovieri AT...	0.0	[1..851]	[1..851]
gi\|77962849 - gi\|77962849\|ref\|ZP_00826665.1\| COG0249: Mismatch repair ATPase (MutS family) [Yersinia mollaretii AT...	0.0	[1..851]	[1..851]
gi\|125617373, gi... - gi\|75829241\|ref\|ZP_00758551.1\| COG0249: Mismatch repair ATPase (MutS family) [Vibrio cholerae MO10],... gi\|229353916, gi... - gi\|229508991\|ref\|ZP_04398479.1\| DNA mismatch repair protein MutS [Vibrio cholerae B33], gi\|229353916... MUTS_VIBCH - DNA mismatch repair protein mutS OS=Vibrio cholerae GN=mutS PE=3 SV=1 MUTS_VIBCH - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N1... gi\|75815683 - gi\|75815683\|ref\|ZP_00746180.1\| COG0249: Mismatch repair ATPase (MutS family) [Vibrio cholerae V52] MUTS_VIBCM - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain M66-2) GN=mutS PE=3 SV=1 gi\|229507146, gi... - gi\|229507146\|ref\|ZP_04396652.1\| DNA mismatch repair protein MutS [Vibrio cholerae BX 330286], gi\|229... gi\|229344348, gi... - gi\|229519659\|ref\|ZP_04409102.1\| DNA mismatch repair protein MutS [Vibrio cholerae RC9], gi\|229344348... MUTS_VIBC3 - DNA mismatch repair protein MutS OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa... gi\|153223827, gi... - gi\|153223827\|ref\|ZP_01954082.1\| DNA mismatch repair protein MutS [Vibrio cholerae MAK 757], gi\|12411... gi\|126510344, gi... - gi\|153819112\|ref\|ZP_01971779.1\| DNA mismatch repair protein MutS [Vibrio cholerae NCTC 8457], gi\|126...	0.0	[3..851]	[8..862]
gi\|254850775, gi... - gi\|254850775\|ref\|ZP_05240125.1\| DNA mismatch repair protein MutS [Vibrio cholerae MO10], gi\|25484648... gi\|229368830, gi... - gi\|229606175\|ref\|YP_002876823.1\| DNA mismatch repair protein MutS [Vibrio cholerae MJ-1236], gi\|2293... tr\|C6YK41\|C6YK41... - DNA mismatch repair protein MutS OS=Vibrio cholerae MO10 GN=mutS PE=3 SV=1 gi\|75825907 - gi\|75825907\|ref\|ZP_00755342.1\| COG0249: Mismatch repair ATPase (MutS family) [Vibrio cholerae O395]	0.0	[3..851]	[25..879]
MUTS_YERPA - DNA mismatch repair protein MutS OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=mutS PE=3 SV=1 gi\|167050865, gi... - gi\|167398361\|ref\|ZP_02303885.1\| DNA mismatch repair protein MutS [Yersinia pestis biovar Antiqua str...	0.0	[1..851]	[1..854]
gi\|116219810, gi... - gi\|75819256\|ref\|ZP_00749345.1\| COG0249: Mismatch repair ATPase (MutS family) [Vibrio cholerae V51], ...	0.0	[3..851]	[25..879]

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Predicted Domain #1

Region A:
Residues: [1-851]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNNDKLDSH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YSDAKRASQL LDISLTKRGA  60
   61 SAGEPIPMAG VPYHSIENYL AKLVQLGESA AICEQIGDPA TSKGPVERKV VRIVTPGTIS 120
  121 DEALLQERQD NLLAAIWQDA KGFGYATLDI SSGRFRVAEP ADLETMAAEL QRTNPAELLY 180
  181 PENFEPMSLI EHRHGLRRRP LWEFELDTAK QQLNLQFGTR DLIGFGVEQA HLALRAAGCL 240
  241 LQYVKDTQRT SLPHIRGLTM ERQQDGIIMD AATRRNLELT QNLSGGSENT LAAILDCSVT 300
  301 PMGSRMLKRW LHMPIRDIRV LTDRQQAIGG LQDIAAELQT PLRQVGDLER ILARLALRTA 360
  361 RPRDLARMRH AFQQLPEIHR LLQPIDVPHV QNLLSQVGQF DELQDLLERA IVETPPVLVR 420
  421 DGGVIASGYN AELDEWRALA DGATDYLDRL EIREREKLGL DTLKVGFNGV HGYYIQVSRG 480
  481 QSHLVPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LAIEKGLYEE IFDLLLPHLP 540
  541 ELQLSANALA ELDVLANLAE RAETLNYSCP TLSDKPGIKI MGGRHPVVEQ VLKEPFISNP 600
  601 LTLSPQRRML IITGPNMGGK STYMRQTALI VLLAHLGSYV PADQATIGPI DRIFTRVGAA 660
  661 DDLASGRSTF MVEMTETANI LHNATEQSLV LMDEIGRGTS TYDGLSLAWA CAENLASRIK 720
  721 AMTLFATHYF ELTTLPEKME GVVNVHLDAL EHGETIAFMH SVQEGAASKS YGLAVAALAG 780
  781 VPRDVIKRAR QKLKELESLS NNAAASTIDG SQMTLLNEEI PPAVEALEAL DPDSLSPRQA 840
  841 LEWIYRLKNM V

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1e3mA
Description:	DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
mismatched DNA binding	7.6300905919597	bayes_pls_golite062009
	6.67853997762091	bayes_pls_golite062009
guanine/thymine mispair binding	6.45283004617788	bayes_pls_golite062009
DNA insertion or deletion binding	6.26024791706598	bayes_pls_golite062009
oxidized purine DNA binding	5.89391492251368	bayes_pls_golite062009
oxidized DNA binding	5.89391492251368	bayes_pls_golite062009
single guanine insertion binding	5.89391492251368	bayes_pls_golite062009
dinucleotide repeat insertion binding	5.18682154515498	bayes_pls_golite062009
single base insertion or deletion binding	5.15853852267378	bayes_pls_golite062009
single thymine insertion binding	4.26884084912691	bayes_pls_golite062009
dinucleotide insertion or deletion binding	4.09431251446007	bayes_pls_golite062009
loop DNA binding	3.13510929288157	bayes_pls_golite062009
mismatch repair complex binding	2.99730753457176	bayes_pls_golite062009
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
binding	2.4974940028864	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.16381244011837	bayes_pls_golite062009
pyrophosphatase activity	2.13284212711072	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.11265775498161	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.11046854230259	bayes_pls_golite062009
DNA helicase activity	2.10134737488849	bayes_pls_golite062009
double-strand/single-strand DNA junction binding	2.02697209084624	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.71882026185027	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
hydrolase activity	1.66122526893602	bayes_pls_golite062009
microtubule motor activity	1.6537049553461	bayes_pls_golite062009
ATPase activity	1.53315090215319	bayes_pls_golite062009
structure-specific DNA binding	1.2539059700735	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
motor activity	1.14667913749579	bayes_pls_golite062009
double-stranded DNA binding	1.117585097627	bayes_pls_golite062009
nucleic acid binding	1.08697924060619	bayes_pls_golite062009
protein-DNA loading ATPase activity	1.08464552192299	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
DNA clamp loader activity	0.91282941965371	bayes_pls_golite062009
DNA binding	0.702147676354075	bayes_pls_golite062009
single-stranded DNA binding	0.568457189190858	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
transcription regulator activity	0.287777990975748	bayes_pls_golite062009
four-way junction helicase activity	0.26252931460003	bayes_pls_golite062009
protein binding	0.193768631623192	bayes_pls_golite062009
exodeoxyribonuclease V activity	0.185603938981231	bayes_pls_golite062009
nucleotide binding	0.114848452385726	bayes_pls_golite062009
purine nucleotide binding	0.10713474095071	bayes_pls_golite062009
purine ribonucleotide binding	0.0916519414118148	bayes_pls_golite062009
ribonucleotide binding	0.0915913646217636	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: