YRC Public Data Repository - Protein Structure Prediction

Protein:	GLTP_ECOLI
Organism:	Escherichia coli
Length:	437 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLTP_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|49610981, gi\|... - gi\|50120455\|ref\|YP_049622.1\| glutamate/aspartate:proton symporter [Pectobacterium atrosepticum SCRI1...	384.0	[0..1]	[437..3]
gi\|238793306, gi... - gi\|77978119\|ref\|ZP_00833552.1\| COG1301: Na+/H+-dicarboxylate symporters [Yersinia intermedia ATCC 29...	383.0	[0..1]	[437..1]
gi\|75258995, gi\|... - gi\|75258995\|ref\|ZP_00730363.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli E22], gi\|1... gi\|194426742, gi... - gi\|75212004\|ref\|ZP_00712059.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli B171], gi\|...	382.0	[0..1]	[437..1]
gi\|190907756, gi... - gi\|75241119\|ref\|ZP_00724993.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli F11], gi\|1... gi\|74314570, gi\|... - gi\|74314570\|ref\|YP_312989.1\| glutamate/aspartate:proton symporter [Shigella sonnei Ss046], gi\|738580... gi\|187731927, gi... - gi\|75179556\|ref\|ZP_00699560.1\| COG1301: Na+/H+-dicarboxylate symporters [Shigella boydii BS512], gi\|... gi\|190901198, gi... - gi\|75228017\|ref\|ZP_00714703.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli B7A], gi\|1... gi\|81247832, gi\|... - gi\|82546421\|ref\|YP_410368.1\| glutamate/aspartate:proton symporter [Shigella boydii Sb227], gi\|812478... gi\|188017445, gi... - gi\|188017445\|gb\|EDU55567.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC4113],... gi\|189357545, gi... - gi\|189357545\|gb\|EDU75964.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC4401],... gi\|168760932, gi... - gi\|189368654\|gb\|EDU87070.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC4501],... gi\|189364294, gi... - gi\|189364294\|gb\|EDU82713.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC4486],... gi\|187769914, gi... - gi\|187769914\|gb\|EDU33758.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC4196],... gi\|189001822, gi... - gi\|189001822\|gb\|EDU70808.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC4076],... gi\|189375121, gi... - gi\|189375121\|gb\|EDU93537.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC869], ... gi\|124501159, gi... - gi\|124527716\|ref\|ZP_01699151.1\| sodium:dicarboxylate symporter [Escherichia coli B], gi\|124501159\|gb... gi\|209751022, gi... - pir\|\|G86101 glutamate-aspartate symport protein [imported] - Escherichia coli (strain O157:H7, subst... gi\|209399923, gi... - gi\|209399923\|ref\|YP_002273619.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC4... gi\|215267494, gi... - gi\|215489422\|ref\|YP_002331853.1\| glutamate/aspartate:proton symporter [Escherichia coli O127:H6 str.... gi\|15834313, gi\|... - gi\|15834313\|ref\|NP_313086.1\| glutamate-aspartate symport protein [Escherichia coli O157:H7], gi\|1336... gi\|217325960, gi... - gi\|217325960\|ref\|ZP_03442044.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. TW14... gi\|26111318, gi\|... - gi\|26250886\|ref\|NP_756926.1\| glutamate/aspartate:proton symporter [Escherichia coli CFT073], gi\|2611... gi\|218702743, gi... - gi\|218702743\|ref\|YP_002410372.1\| glutamate/aspartate:proton symporter [Escherichia coli IAI39], gi\|2... gi\|254796097, gi... - gi\|254796097\|ref\|YP_003080934.1\| glutamate/aspartate:proton symporter [Escherichia coli O157:H7 str.... gi\|218707699, gi... - gi\|218707699\|ref\|YP_002415218.1\| glutamate/aspartate:proton symporter [Escherichia coli UMN026], gi\|... gi\|227836034, gi... - gi\|227886893\|ref\|ZP_04004698.1\| DAACS family dicarboxylate/amino acid:sodium (Na+) or proton (H+) sy... gi\|15804669, gi\|... - gi\|15804669\|ref\|NP_290710.1\| glutamate/aspartate:proton symporter [Escherichia coli O157:H7 EDL933],... gi\|168798254, gi... - gi\|189379114\|gb\|EDU97530.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC508], ... gi\|15834313, gi\|... - gi\|15834313\|ref\|NP_313086.1\| glutamate/aspartate:proton symporter [Escherichia coli O157:H7 str. Sak... gi\|170021924, gi... - gi\|170021924\|ref\|YP_001726878.1\| glutamate/aspartate:proton symporter [Escherichia coli ATCC 8739], ... gi\|110346021, gi... - gi\|110644429\|ref\|YP_672159.1\| glutamate/aspartate:proton symporter [Escherichia coli 536], gi\|110346... gi\|170684035, gi... - gi\|170684035\|ref\|YP_001746468.1\| proton glutamate symport protein [Escherichia coli SMS-3-5], gi\|170... gi\|194432307, gi... - gi\|194432307\|ref\|ZP_03064595.1\| proton glutamate symport protein [Shigella dysenteriae 1012], gi\|194... gi\|195935863 - gi\|195935863\|ref\|ZP_03081245.1\| glutamate/aspartate:proton symporter [Escherichia coli O157:H7 str. ... gi\|208808912, gi... - gi\|208808912\|ref\|ZP_03251249.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC42... gi\|208735076, gi... - gi\|208813799\|ref\|ZP_03255128.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC40... gi\|208741750, gi... - gi\|208821627\|ref\|ZP_03261947.1\| proton glutamate symport protein [Escherichia coli O157:H7 str. EC40...	382.0	[0..1]	[437..1]
gi\|91075195, gi\|... - gi\|91213621\|ref\|YP_543607.1\| glutamate/aspartate:proton symporter [Escherichia coli UTI89], gi\|91075... gi\|115515482, gi... - gi\|117626358\|ref\|YP_859681.1\| glutamate/aspartate:proton symporter [Escherichia coli APEC O1], gi\|11... gi\|218561162, gi... - gi\|218561162\|ref\|YP_002394075.1\| glutamate/aspartate:proton symporter [Escherichia coli S88], gi\|218... gi\|226901570, gi... - gi\|237703658\|ref\|ZP_04534139.1\| glutamate/aspartate:proton symporter [Escherichia sp. 3_2_53FAA], gi...	382.0	[0..1]	[437..1]
gi\|218697786, gi... - gi\|218697786\|ref\|YP_002405453.1\| glutamate/aspartate:proton symporter [Escherichia coli 55989], gi\|2... gi\|253775295, gi... - gi\|254290762\|ref\|YP_003056510.1\| glutamate/aspartate:proton symporter [Escherichia coli BL21(DE3)], ... gi\|251787331, gi... - gi\|251787331\|ref\|YP_003001635.1\| hypothetical protein B21_03909 [Escherichia coli BL21], gi\|24237960... gi\|209921564, gi... - gi\|209921564\|ref\|YP_002295648.1\| glutamate/aspartate:proton symporter [Escherichia coli SE11], gi\|20... gi\|218363404, gi... - gi\|218556635\|ref\|YP_002389549.1\| glutamate/aspartate:proton symporter [Escherichia coli IAI1], gi\|21... gi\|75514836, gi\|... - gi\|75514836\|ref\|ZP_00737065.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli 53638], gi... gi\|157163547, gi... - gi\|75197935\|ref\|ZP_00708005.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli HS], gi\|15... gi\|157077934, gi... - gi\|75188800\|ref\|ZP_00702067.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli E24377A], ... gi\|194437278, gi... - gi\|83587201\|ref\|ZP_00925830.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli 101-1], gi...	381.0	[0..1]	[437..1]
gi\|238796163, gi... - gi\|77962489\|ref\|ZP_00826308.1\| COG1301: Na+/H+-dicarboxylate symporters [Yersinia mollaretii ATCC 43...	379.0	[0..1]	[434..1]
gi\|110807904, gi... - gi\|110807904\|ref\|YP_691424.1\| glutamate/aspartate:proton symporter [Shigella flexneri 5 str. 8401], ...	379.0	[0..1]	[437..1]
gi\|193067824, gi... - gi\|75238612\|ref\|ZP_00722601.1\| COG1301: Na+/H+-dicarboxylate symporters [Escherichia coli E110019], ...	379.0	[0..1]	[437..1]
gi\|24054646, gi\|... - gi\|24115343\|ref\|NP_709853.1\| glutamate/aspartate:proton symporter [Shigella flexneri 2a str. 301], g... gi\|30064666, gi\|... - gi\|30064666\|ref\|NP_838837.1\| glutamate/aspartate:proton symporter [Shigella flexneri 2a str. 2457T],...	379.0	[0..1]	[437..1]

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Predicted Domain #1

Region A:
Residues: [1-437]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNIKFSLAW QILFAMVLGI LLGSYLHYHS DSRDWLVVNL LSPAGDIFIH LIKMIVVPIV  60
   61 ISTLVVGIAG VGDAKQLGRI GAKTIIYFEV ITTVAIILGI TLANVFQPGA GVDMSQLATV 120
  121 DISKYQSTTE AVQSSSHGIM GTILSLVPTN IVASMAKGEM LPIIFFSVLF GLGLSSLPAT 180
  181 HREPLVTVFR SISETMFKVT HMVMRYAPVG VFALIAVTVA NFGFSSLWPL AKLVLLVHFA 240
  241 ILFFALVVLG IVARLCGLSV WILIRILKDE LILAYSTASS ESVLPRIIEK MEAYGAPVSI 300
  301 TSFVVPTGYS FNLDGSTLYQ SIAAIFIAQL YGIDLSIWQE IILVLTLMVT SKGIAGVPGV 360
  361 SFVVLLATLG SVGIPLEGLA FIAGVDRILD MARTALNVVG NALAVLVIAK WEHKFDRKKA 420
  421 LAYEREVLGK FDKTADQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	84.522879
Match:	1xfhA
Description:	Structure of glutamate transporter homolog from Pyrococcus horikoshii
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dicarboxylic acid transmembrane transporter activity	6.43530691895523	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	6.20769381184606	bayes_pls_golite062009
organic acid transmembrane transporter activity	6.19258658226115	bayes_pls_golite062009
anion:cation symporter activity	5.39486898992441	bayes_pls_golite062009
transporter activity	5.14616859489508	bayes_pls_golite062009
substrate-specific transporter activity	5.08516306839475	bayes_pls_golite062009
transmembrane transporter activity	5.06400974103865	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.03536308870823	bayes_pls_golite062009
L-aspartate transmembrane transporter activity	4.75851143790089	bayes_pls_golite062009
ion transmembrane transporter activity	4.56245375639148	bayes_pls_golite062009
cation transmembrane transporter activity	4.38524103588396	bayes_pls_golite062009
active transmembrane transporter activity	4.37939766329509	bayes_pls_golite062009
secondary active transmembrane transporter activity	3.93820513423101	bayes_pls_golite062009
amine transmembrane transporter activity	3.7335977004076	bayes_pls_golite062009
L-amino acid transmembrane transporter activity	3.55306444119183	bayes_pls_golite062009
solute:cation symporter activity	3.47181854698038	bayes_pls_golite062009
symporter activity	3.47181854698038	bayes_pls_golite062009
organic acid:sodium symporter activity	3.44677545809568	bayes_pls_golite062009
amino acid transmembrane transporter activity	3.22640982674356	bayes_pls_golite062009
L-glutamate transmembrane transporter activity	3.01617678444307	bayes_pls_golite062009
acidic amino acid transmembrane transporter activity	3.01617678444307	bayes_pls_golite062009
high-affinity glutamate transmembrane transporter activity	2.687419691871	bayes_pls_golite062009
C4-dicarboxylate transmembrane transporter activity	2.522484225611	bayes_pls_golite062009
sodium:dicarboxylate symporter activity	2.28671365705239	bayes_pls_golite062009
anion transmembrane transporter activity	2.02127810434029	bayes_pls_golite062009
solute:sodium symporter activity	1.76557983021416	bayes_pls_golite062009
amine binding	1.22219692417544	bayes_pls_golite062009
solute:hydrogen symporter activity	0.96942313177856	bayes_pls_golite062009
binding	0.92648751720567	bayes_pls_golite062009
sulfur amino acid transmembrane transporter activity	0.791452273778402	bayes_pls_golite062009
L-cystine transmembrane transporter activity	0.577818180430181	bayes_pls_golite062009
glutamate:sodium symporter activity	0.553718735358201	bayes_pls_golite062009
neutral amino acid transmembrane transporter activity	0.444280550441749	bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity	0.31624582149961	bayes_pls_golite062009
protein binding	0.241603585422086	bayes_pls_golite062009
passive transmembrane transporter activity	0.119412711778045	bayes_pls_golite062009
channel activity	0.119412711778045	bayes_pls_golite062009
substrate-specific channel activity	0.0999184515491418	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: