YRC Public Data Repository - Protein Structure Prediction

Protein:	DCTA_ECOLI
Organism:	Escherichia coli
Length:	428 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DCTA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|148262464, gi... - gi\|88935333\|ref\|ZP_01140966.1\| DAACS family, C4-dicarboxylic acids transport protein [Geobacter uran...	382.0	[0..1]	[427..1]
DCTA_ACIAC - C4-dicarboxylate transport protein OS=Acidovorax citrulli (strain AAC00-1) GN=dctA PE=3 SV=1	379.0	[0..2]	[427..11]
DCTA2_POLNA - C4-dicarboxylate transport protein 2 OS=Polaromonas naphthalenivorans (strain CJ2) GN=dctA2 PE=3 SV=...	378.0	[0..2]	[426..7]
DCTA2_CUPMC - C4-dicarboxylate transport protein 2 OS=Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NB...	377.0	[0..2]	[426..7]
DCTA2_PSEA7 - C4-dicarboxylate transport protein 2 OS=Pseudomonas aeruginosa (strain PA7) GN=dctA2 PE=3 SV=1	377.0	[0..2]	[425..3]
gi\|107100632 - gi\|107100632\|ref\|ZP_01364550.1\| hypothetical protein PaerPA_01001658 [Pseudomonas aeruginosa PACS2] DCTA2_PSEAE - C4-dicarboxylate transport protein 2 OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS ... gi\|218773081, gi... - gi\|218892853\|ref\|YP_002441722.1\| C4-dicarboxylate transporter DctA [Pseudomonas aeruginosa LESB58], ... gi\|194545301, gi... - gi\|84322175\|ref\|ZP_00970520.1\| COG1301: Na+/H+-dicarboxylate symporters [Pseudomonas aeruginosa C371... DCTA2_PSEAE, DTA... - (Q9I4F5) C4-dicarboxylate transport protein 2, C4-dicarboxylate transport protein 2 OS=Pseudomonas a... DCTA2_PSEAB - C4-dicarboxylate transport protein 2 OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=dctA2 PE=3 SV=...	376.0	[0..2]	[425..3]
gi\|84328655, gi\|... - gi\|84328655\|ref\|ZP_00976659.1\| COG1301: Na+/H+-dicarboxylate symporters [Pseudomonas aeruginosa 2192...	376.0	[0..2]	[425..3]
DCTA_SHIDS - C4-dicarboxylate transport protein OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=dctA PE=3 SV...	374.0	[0..1]	[428..1]
gi\|14025620, gi\|... - gi\|14025620\|dbj\|BAB52220.1\| C4-dicarboxylate transport protein [Mesorhizobium loti MAFF303099], gi\|1...	373.0	[0..2]	[424..34]

Back

Predicted Domain #1

Region A:
Residues: [1-428]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTSLFKSLY FQVLTAIAIG ILLGHFYPEI GEQMKPLGDG FVKLIKMIIA PVIFCTVVTG  60
   61 IAGMESMKAV GRTGAVALLY FEIVSTIALI IGLIIVNVVQ PGAGMNVDPA TLDAKAVAVY 120
  121 ADQAKDQGIV AFIMDVIPAS VIGAFASGNI LQVLLFAVLF GFALHRLGSK GQLIFNVIES 180
  181 FSQVIFGIIN MIMRLAPIGA FGAMAFTIGK YGVGTLVQLG QLIICFYITC ILFVVLVLGS 240
  241 IAKATGFSIF KFIRYIREEL LIVLGTSSSE SALPRMLDKM EKLGCRKSVV GLVIPTGYSF 300
  301 NLDGTSIYLT MAAVFIAQAT NSQMDIVHQI TLLIVLLLSS KGAAGVTGSG FIVLAATLSA 360
  361 VGHLPVAGLA LILGIDRFMS EARALTNLVG NGVATIVVAK WVKELDHKKL DDVLNNRAPD 420
  421 GKTHELSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.30103
Match:	1xfhA
Description:	Structure of glutamate transporter homolog from Pyrococcus horikoshii
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
dicarboxylic acid transmembrane transporter activity	6.43530691895523	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	6.20769381184606	bayes_pls_golite062009
organic acid transmembrane transporter activity	6.19258658226115	bayes_pls_golite062009
anion:cation symporter activity	5.39486898992441	bayes_pls_golite062009
transporter activity	5.14616859489508	bayes_pls_golite062009
substrate-specific transporter activity	5.08516306839475	bayes_pls_golite062009
transmembrane transporter activity	5.06400974103865	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.03536308870823	bayes_pls_golite062009
L-aspartate transmembrane transporter activity	4.75851143790089	bayes_pls_golite062009
ion transmembrane transporter activity	4.56245375639148	bayes_pls_golite062009
sodium:dicarboxylate symporter activity	4.40071591934747	bayes_pls_golite062009
cation transmembrane transporter activity	4.38524103588396	bayes_pls_golite062009
active transmembrane transporter activity	4.37939766329509	bayes_pls_golite062009
secondary active transmembrane transporter activity	3.93820513423101	bayes_pls_golite062009
amine transmembrane transporter activity	3.7335977004076	bayes_pls_golite062009
L-amino acid transmembrane transporter activity	3.55306444119183	bayes_pls_golite062009
solute:cation symporter activity	3.47181854698038	bayes_pls_golite062009
symporter activity	3.47181854698038	bayes_pls_golite062009
organic acid:sodium symporter activity	3.44677545809568	bayes_pls_golite062009
amino acid transmembrane transporter activity	3.22640982674356	bayes_pls_golite062009
L-glutamate transmembrane transporter activity	3.01617678444307	bayes_pls_golite062009
acidic amino acid transmembrane transporter activity	3.01617678444307	bayes_pls_golite062009
high-affinity glutamate transmembrane transporter activity	2.687419691871	bayes_pls_golite062009
C4-dicarboxylate transmembrane transporter activity	2.522484225611	bayes_pls_golite062009
anion transmembrane transporter activity	2.02127810434029	bayes_pls_golite062009
solute:sodium symporter activity	1.76557983021416	bayes_pls_golite062009
amine binding	1.22219692417544	bayes_pls_golite062009
solute:hydrogen symporter activity	0.96942313177856	bayes_pls_golite062009
binding	0.92648751720567	bayes_pls_golite062009
sulfur amino acid transmembrane transporter activity	0.791452273778402	bayes_pls_golite062009
L-cystine transmembrane transporter activity	0.577818180430181	bayes_pls_golite062009
glutamate:sodium symporter activity	0.553718735358201	bayes_pls_golite062009
neutral amino acid transmembrane transporter activity	0.444280550441749	bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity	0.31624582149961	bayes_pls_golite062009
protein binding	0.241603585422086	bayes_pls_golite062009
passive transmembrane transporter activity	0.119412711778045	bayes_pls_golite062009
channel activity	0.119412711778045	bayes_pls_golite062009
substrate-specific channel activity	0.0999184515491418	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: