YRC Public Data Repository - Protein Structure Prediction

Protein:	ATZN_ECOLI
Organism:	Escherichia coli
Length:	732 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATZN_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|242258479, gi... - gi\|242258479\|ref\|ZP_04803277.1\| copper-translocating P-type ATPase [Thermoanaerobacter sp. X513], gi... gi\|241903577, gi... - gi\|241903577\|ref\|ZP_04788299.1\| copper-translocating P-type ATPase [Thermoanaerobacter brockii subsp... gi\|76588523, gi\|... - gi\|76796112\|ref\|ZP_00778480.1\| ATPase, E1-E2 type:Copper ion-binding:Copper-translocating P-type ATP... gi\|114844533, gi... - gi\|167039429\|ref\|YP_001662414.1\| copper-translocating P-type ATPase [Thermoanaerobacter sp. X514], g...	671.0	[0..7]	[732..30]
gi\|20808818 - gi\|20808818\|ref\|NP_623989.1\| Cation transport ATPase [Thermoanaerobacter tengcongensis MB4] gi\|20517469, gi\|... - gi\|20808818\|ref\|NP_623989.1\| cation transport ATPase [Thermoanaerobacter tengcongensis MB4], gi\|2051...	671.0	[0..7]	[732..30]
gi\|56419437, gi\|... - gi\|56419437\|ref\|YP_146755.1\| heavy metal-transporting ATPase [Geobacillus kaustophilus HTA426], gi\|5...	669.0	[0..3]	[732..28]
gi\|27262376 - gi\|27262376\|gb\|AAN87469.1\| Copper-importing ATPase [Heliobacillus mobilis]	658.0	[0..3]	[732..62]
gi\|145408869, gi... - gi\|82499630\|ref\|ZP_00885070.1\| ATPase, E1-E2 type:Copper ion-binding:Copper-translocating P-type ATP...	657.0	[0..3]	[732..25]
COPA_BACSU - Copper-exporting P-type ATPase A OS=Bacillus subtilis GN=copA PE=1 SV=1 gi\|2635863, gi\|1... - gi\|2635863\|emb\|CAB15355.1\| yvgX [Bacillus subtilis subsp. subtilis str. 168], gi\|16080403\|ref\|NP_391...	655.0	[0..6]	[732..32]
gi\|42782808, gi\|... - gi\|42782808\|ref\|NP_980055.1\| heavy metal-transporting ATPase [Bacillus cereus ATCC 10987], gi\|427387...	655.0	[0..4]	[732..29]
gi\|15613120, gi\|... - gi\|15613120\|ref\|NP_241423.1\| copper-transporting ATPase [Bacillus halodurans C-125], gi\|10173170\|dbj... gi\|25290739 - pir\|\|E83719 copper-transporting ATPase BH0557 [imported] - Bacillus halodurans (strain C-125)	653.0	[0..7]	[732..32]
gi\|89095980, gi\|... - gi\|89095980\|ref\|ZP_01168873.1\| YvgX [Bacillus sp. NRRL B-14911], gi\|89088834\|gb\|EAR67942.1\| YvgX [Ba...	649.0	[0..4]	[732..30]
gi\|89897256, gi\|... - gi\|89897256\|ref\|YP_520743.1\| hypothetical protein DSY4510 [Desulfitobacterium hafniense Y51], gi\|893...	645.0	[0..2]	[732..24]

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Predicted Domain #1

Region A:
Residues: [1-118]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPDNHGKK APQFAAFKPL TTVQNANDCC CDGACSSTPT LSENVSGTRY SWKVSGMDCA  60
   61 ACARKVENAV RQLAGVNQVQ VLFATEKLVV DADNDIRAQV ESALQKAGYS LRDEQAAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.0
Match:	1mwyA
Description:	Metal ion-transporting ATPase ZntA, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
copper chaperone activity	5.99007447506957	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.4007166857771	bayes_pls_golite062009
copper ion transmembrane transporter activity	5.18510514935825	bayes_pls_golite062009
copper-exporting ATPase activity	5.04749761961029	bayes_pls_golite062009
copper-transporting ATPase activity	5.03252922496602	bayes_pls_golite062009
copper ion binding	5.01875130037421	bayes_pls_golite062009
metallochaperone activity	4.85524337397713	bayes_pls_golite062009
transition metal ion transmembrane transporter activity	4.79570221435856	bayes_pls_golite062009
copper-dependent protein binding	4.71729267115962	bayes_pls_golite062009
cation transmembrane transporter activity	4.61622753861072	bayes_pls_golite062009
ion transmembrane transporter activity	4.52484959112186	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.12792340516867	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	4.10264569844449	bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity	3.70964017127302	bayes_pls_golite062009
superoxide dismutase copper chaperone activity	3.50705492219116	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	3.27250923701445	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions	2.98847682261773	bayes_pls_golite062009
transition metal ion binding	2.6049784579434	bayes_pls_golite062009
transporter activity	2.43435890488191	bayes_pls_golite062009
transmembrane transporter activity	2.32163502360862	bayes_pls_golite062009
substrate-specific transporter activity	2.28845421748925	bayes_pls_golite062009
metal ion binding	1.84981492985167	bayes_pls_golite062009
cation binding	1.84981492985167	bayes_pls_golite062009
binding	1.84926272403445	bayes_pls_golite062009
primary active transmembrane transporter activity	1.62116507842838	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	1.61680623728503	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	1.59572740343301	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	1.5925429451548	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	1.59219836319916	bayes_pls_golite062009
active transmembrane transporter activity	1.53883152283038	bayes_pls_golite062009
ATPase activity	1.12732384636594	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.1123150216263	bayes_pls_golite062009
ion binding	1.07409701266582	bayes_pls_golite062009
pyrophosphatase activity	1.04872000948037	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.03270166246194	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.02977205960797	bayes_pls_golite062009
ATPase activity, coupled	1.02520458852568	bayes_pls_golite062009
hydrolase activity	0.887060142135599	bayes_pls_golite062009
cation-transporting ATPase activity	0.75722873989123	bayes_pls_golite062009
protein binding	0.736752132095517	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [119-732]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPQASRLKEN LPLITLIVMM AISWGLEQFN HPFGQLAFIA TTLVGLYPIA RQALRLIKSG  60
   61 SYFAIETLMS VAAIGALFIG ATAEAAMVLL LFLIGERLEG WAASRARQGV SALMALKPET 120
  121 ATRLRKGERE EVAINSLRPG DVIEVAAGGR LPADGKLLSP FASFDESALT GESIPVERAT 180
  181 GDKVPAGATS VDRLVTLEVL SEPGASAIDR ILKLIEEAEE RRAPIERFID RFSRIYTPAI 240
  241 MAVALLVTLV PPLLFAASWQ EWIYKGLTLL LIGCPCALVI STPAAITSGL AAAARRGALI 300
  301 KGGAALEQLG RVTQVAFDKT GTLTVGKPRV TAIHPATGIS ESELLTLAAA VEQGATHPLA 360
  361 QAIVREAQVA ELAIPTAESQ RALVGSGIEA QVNGERVLIC AAGKHPADAF TGLINELESA 420
  421 GQTVVLVVRN DDVLGVIALQ DTLRADAATA ISELNALGVK GVILTGDNPR AAAAIAGELG 480
  481 LEFKAGLLPE DKVKAVTELN QHAPLAMVGD GINDAPAMKA AAIGIAMGSG TDVALETADA 540
  541 ALTHNHLRGL VQMIELARAT HANIRQNITI ALGLKGIFLV TTLLGMTGLW LAVLADTGAT 600
  601 VLVTANALRL LRRR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.09691
Match:	1mhsA
Description:	Proton ATPase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: