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View Structure Prediction Details

Protein: lgc-35
Organism: Caenorhabditis elegans
Length: 515 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lgc-35.

Description E-value Query
Range
Subject
Range
gi|109085980 - gi|109085980|ref|XP_001109335.1| PREDICTED: cholinergic receptor, nicotinic, alpha polypeptide 2 (ne...
350.0 [0..1] [496..1]

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Predicted Domain #1
Region A:
Residues: [1-373]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSLVSKRME FGKIVLLVLV IMEMVQICSG VRAALRLRKK SNSADDSEDE EMQDEIDNAI  60
   61 YDKASIFEQG ETHDFLQFLR SIKYDHRQVP DDGYDGPVHV NVSIVVSNIR SVSEVTMDYS 120
  121 IEMFYRESWR DPRLTYSRDK FKNKTEISLH ESYSNYLWHP DTFVPNAISS KNPRRQSITH 180
  181 RSLLRLRNNG SILYSRRLSL ILTCGMDLTL FPFDTQLCKM GFESYGYTAD KVKYLWSTGA 240
  241 IQSLKLHKIR LPDFQVKEAY VTSRVESYAT GDYSRLYVCF VFNRAAGFCF LQLIIPSTAV 300
  301 VITSWVSLWM ENETSFQDMI SIILTITFLL FSYNEVMPRV SYIKAMDVYL GVCFCIVFLS 360
  361 LIKLAAVKYM RQR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.69897
Match: 2bg9A
Description: Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [374-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLITRDTSIV AAGMLPMLRL VNGIGSPAVN GSEGFTYENP AVKKVSMSPD TFTQVQMETN  60
   61 GSMSPVCRQN RAKDNGNVSQ SSNCFEFSPT FMHRFHWITQ MTFFFGFVIF CLFYFLVYPN 120
  121 IHTQITDDDC DRQMAEWFAE IH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 1oedA
Description: Acetylcholine receptor protein, alpha chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cation channel activity 11.1823056937132 bayes_pls_golite062009
ion channel activity 11.1753684044644 bayes_pls_golite062009
nicotinic acetylcholine-activated cation-selective channel activity 11.1208555364265 bayes_pls_golite062009
passive transmembrane transporter activity 11.0903806681397 bayes_pls_golite062009
channel activity 11.0903806681397 bayes_pls_golite062009
gated channel activity 11.0397691626728 bayes_pls_golite062009
metal ion transmembrane transporter activity 10.9870635461822 bayes_pls_golite062009
substrate-specific channel activity 10.9375522860542 bayes_pls_golite062009
extracellular ligand-gated ion channel activity 9.75096408199907 bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity 9.75096408199907 bayes_pls_golite062009
ligand-gated channel activity 9.34902726749692 bayes_pls_golite062009
ligand-gated ion channel activity 9.34902726749692 bayes_pls_golite062009
acetylcholine binding 8.89748048814778 bayes_pls_golite062009
acetylcholine receptor activity 8.63094174477134 bayes_pls_golite062009
amine binding 7.31839282808397 bayes_pls_golite062009
ion transmembrane transporter activity 7.22265353460749 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 6.7875346065164 bayes_pls_golite062009
cation transmembrane transporter activity 6.75385972663331 bayes_pls_golite062009
neurotransmitter binding 6.11782125343012 bayes_pls_golite062009
neurotransmitter receptor activity 5.97698567435878 bayes_pls_golite062009
chloride channel regulator activity 5.57216711685731 bayes_pls_golite062009
transmembrane receptor activity 5.4080353535498 bayes_pls_golite062009
receptor activity 5.11329651194787 bayes_pls_golite062009
transporter activity 5.11262082564788 bayes_pls_golite062009
transmembrane transporter activity 5.03439798256257 bayes_pls_golite062009
substrate-specific transporter activity 4.91314874981447 bayes_pls_golite062009
molecular transducer activity 4.12549692767753 bayes_pls_golite062009
signal transducer activity 4.12549692767753 bayes_pls_golite062009
G-protein coupled receptor activity 3.09231388867595 bayes_pls_golite062009
binding 2.4916526322278 bayes_pls_golite062009
beta-amyloid binding 1.58357526631942 bayes_pls_golite062009
G-protein coupled amine receptor activity 1.37431949258757 bayes_pls_golite062009
serotonin binding 1.33584589886834 bayes_pls_golite062009
serotonin-activated cation-selective channel activity 1.31324203158511 bayes_pls_golite062009
1.15330735898282 bayes_pls_golite062009
channel regulator activity 1.13923307634251 bayes_pls_golite062009
toxin binding 1.03329843925063 bayes_pls_golite062009
drug binding 0.64715018605883 bayes_pls_golite062009
protein binding 0.406954670483187 bayes_pls_golite062009
serotonin receptor activity 0.0879353619248899 bayes_pls_golite062009

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