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View Structure Prediction Details

Protein: PTN2A_ARATH
Organism: Arabidopsis thaliana
Length: 611 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTN2A_ARATH.

Description E-value Query
Range		 Subject
Range
gi|27447974 - gi|27447974|gb|AAO13749.1|AF268257_1 PTEN-like protein [Arabidopsis thaliana]
 445.0 [0..1] [611..1]

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Predicted Domain #1
Region A:
Residues: [1-140] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSESPNLPA AAGTVPDNHP PPPPVVTAAE AGSDDSPKGV ASKLSAAGIS NWAKNLKVPQ  60
   61 PFASTQNDSG VENTEKSAFA KFTSGLGIRL SPKSPQTNDT TTEGTSSATE SSFIGTITKG 120
  121 LVDTSKNAVK AVQVKARHAV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.69897
Match: 1ohcA
Description: Proline directed phosphatase CDC14b2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphatase activity 4.32491463105526 bayes_pls_golite062009
phosphoric ester hydrolase activity 3.62225401667721 bayes_pls_golite062009
lipid phosphatase activity 2.77444127020865 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 2.31420088972663 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 2.05577133553311 bayes_pls_golite062009
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 1.72084618199574 bayes_pls_golite062009
binding 1.63082376187819 bayes_pls_golite062009
phosphatidylinositol-3-phosphatase activity 1.34604477322161 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.26980045117425 bayes_pls_golite062009
phosphoprotein phosphatase activity 1.1478558008509 bayes_pls_golite062009
protein binding 1.07441758584517 bayes_pls_golite062009
catalytic activity 1.06283028154109 bayes_pls_golite062009
protein tyrosine phosphatase activity 0.631959343178681 bayes_pls_golite062009
transmembrane receptor activity 0.291525352733402 bayes_pls_golite062009
receptor activity 0.191946218805025 bayes_pls_golite062009
phosphatidylinositol bisphosphate phosphatase activity 0.0736057996833881 bayes_pls_golite062009
hydrolase activity 0.018205178993884 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [141-490] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQNKRRYQEG GFDLDLTYIT ENIIAMGFPA GDMSSGFFGY VEGFYRNQME EVINFLETQH  60
   61 KGKYKVYNLC SERLYDVSLF EGKVASFPFD DHNCPPIHLV TSFCQSAYSW LKEDIENVVV 120
  121 VHCKAGMART GLMICSLLLY LKFFPTAEEC MDFYNQKRCV DGKGLVLPSQ IRYVKYFERI 180
  181 LTYFNGENQP GRRCMLRGFR LHRCPYWIRP SITISDHNGV LFTTKKHPRT KDLSPEDFWF 240
  241 SAPKKGVMVF ALPGEPGLTE LAGDFKIQFH DRQGDFYCWL NTTMMENRVI LKTSELDGFD 300
  301 KRKLPSPGFM VEVVLADINA TIPTNPSSET ASKTPEETSA ANSSPVDGSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.09691
Match: 1d5rA
Description: Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphatase activity 4.32491463105526 bayes_pls_golite062009
phosphoric ester hydrolase activity 3.62225401667721 bayes_pls_golite062009
lipid phosphatase activity 2.77444127020865 bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity 2.31420088972663 bayes_pls_golite062009
phosphatidylinositol trisphosphate phosphatase activity 2.05577133553311 bayes_pls_golite062009
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity 1.72084618199574 bayes_pls_golite062009
binding 1.63082376187819 bayes_pls_golite062009
phosphatidylinositol-3-phosphatase activity 1.34604477322161 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.26980045117425 bayes_pls_golite062009
phosphoprotein phosphatase activity 1.1478558008509 bayes_pls_golite062009
protein binding 1.07441758584517 bayes_pls_golite062009
catalytic activity 1.06283028154109 bayes_pls_golite062009
phospholipase activity 0.689713182053935 bayes_pls_golite062009
protein tyrosine phosphatase activity 0.631959343178681 bayes_pls_golite062009
calcium-dependent phospholipid binding 0.368277796845269 bayes_pls_golite062009
transmembrane receptor activity 0.291525352733402 bayes_pls_golite062009
receptor activity 0.191946218805025 bayes_pls_golite062009
phospholipase C activity 0.105085008317406 bayes_pls_golite062009
phosphatidylinositol bisphosphate phosphatase activity 0.0736057996833881 bayes_pls_golite062009
hydrolase activity 0.018205178993884 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [491-611] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVPGPDKETE NPDKDDVFSD NEGDSTGPTK TTSSASSQTP EAKKSADETA VLTKATEKVS  60
   61 ISGNKGSSQP VQGVTVSKGE ATEKPSGAGV NASSSSESEF KVMAADASVF SFGDEDDFES 120
  121 D

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle