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View Structure Prediction Details

Protein: RFA1B_ARATH
Organism: Arabidopsis thaliana
Length: 604 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RFA1B_ARATH.

Description E-value Query
Range		 Subject
Range
gi|114665746 - gi|114665746|ref|XP_511254.2| PREDICTED: replication protein A1, 70kDa [Pan troglodytes]
 518.0 [0..1] [601..55]

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Predicted Domain #1
Region A:
Residues: [1-150] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENSVTQDGI ATVLANQSLD SSSVRPEIVV QVVDLKPAGN RYTFSANDGK MKIKAMLPAT  60
   61 LTSDIISGKI QNLGLIRLLE YTVNDIPGKS EEKYMLITKC EAVASALDSE IKAEIKASTG 120
  121 IMLKPKHEFV AKSASQIINE QRGNAAPAAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.154902
Match: 2b29A
Description: N-terminal domain of the RPA70 subunit of human replication protein A.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomeric DNA binding 7.07761964836826 bayes_pls_golite062009
single-stranded telomeric DNA binding 6.04637014849887 bayes_pls_golite062009
telomerase inhibitor activity 4.06762092339715 bayes_pls_golite062009
nucleic acid binding 4.02967008021862 bayes_pls_golite062009
DNA binding 3.62735703519187 bayes_pls_golite062009
single-stranded DNA binding 3.59212997362902 bayes_pls_golite062009
structure-specific DNA binding 3.53214384646348 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
transcription regulator activity 2.20239961025491 bayes_pls_golite062009
structural constituent of ribosome 2.13063800565247 bayes_pls_golite062009
structural molecule activity 1.9177190829469 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
transcription factor activity 1.05816813143865 bayes_pls_golite062009
sequence-specific DNA binding 0.86170694706755 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
double-stranded DNA binding 0.378383789953688 bayes_pls_golite062009
nucleotidyltransferase activity 0.325774164899685 bayes_pls_golite062009
four-way junction helicase activity 0.31769813397725 bayes_pls_golite062009
translation regulator activity 0.31332179848255 bayes_pls_golite062009
RNA binding 0.31028563542112 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.263197317040851 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.125256208482441 bayes_pls_golite062009
exoribonuclease activity 0.109774918833391 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0954216620147701 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [151-398] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMTRRVHPL VSLNPYQGSW TIKVRVTNKG VMRTYKNARG EGCVFNVELT DEEGTQIQAT  60
   61 MFNAAARKFY DRFEMGKVYY ISRGSLKLAN KQFKTVQNDY EMTLNENSEV EEASNEEMFT 120
  121 PETKFNFVPI DELGTYVNQK DLIDVIGVVQ SVSPTMSIRR KNDNEMIPKR DITLADETKK 180
  181 TVVVSLWNDL ATGIGQELLD MADNHPVIAI KSLKVGAFQG VSLSTISRSN VVINPNSPEA 240
  241 TKLKSWYD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.0
Match: 1jmcA
Description: Replication protein A 70 KDa subunit (RPA70)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomeric DNA binding 7.07761964836826 bayes_pls_golite062009
single-stranded telomeric DNA binding 6.04637014849887 bayes_pls_golite062009
telomerase inhibitor activity 4.06762092339715 bayes_pls_golite062009
nucleic acid binding 4.02967008021862 bayes_pls_golite062009
DNA binding 3.62735703519187 bayes_pls_golite062009
single-stranded DNA binding 3.59212997362902 bayes_pls_golite062009
structure-specific DNA binding 3.53214384646348 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
transcription regulator activity 2.20239961025491 bayes_pls_golite062009
structural constituent of ribosome 2.13063800565247 bayes_pls_golite062009
structural molecule activity 1.9177190829469 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
transcription factor activity 1.05816813143865 bayes_pls_golite062009
sequence-specific DNA binding 0.86170694706755 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
double-stranded DNA binding 0.378383789953688 bayes_pls_golite062009
nucleotidyltransferase activity 0.325774164899685 bayes_pls_golite062009
four-way junction helicase activity 0.31769813397725 bayes_pls_golite062009
translation regulator activity 0.31332179848255 bayes_pls_golite062009
RNA binding 0.31028563542112 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.263197317040851 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.125256208482441 bayes_pls_golite062009
exoribonuclease activity 0.109774918833391 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0954216620147701 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [399-604] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEGKETSMSA IGSGMSSSAN NGSRSMYSDR VFLSHITSNP SLGEEKPVFF STRAYISFIK  60
   61 PDQTMWYRAC KTCNKKVTEA MDSGYWCESC QKKDQECSLR YIMAVKVSDS TGETWLSAFN 120
  121 DEAEKIIGCT ADDLNDLKSE EGEVNEFQTK LKEATWSSHL FRISVSQQEY NSEKRQRITV 180
  181 RGVSPIDFAA ETRLLLQDIS KNKTSQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 1l1oC
Description: Replication protein A 70 KDa subunit (RPA70)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
telomeric DNA binding 7.07761964836826 bayes_pls_golite062009
single-stranded telomeric DNA binding 6.04637014849887 bayes_pls_golite062009
telomerase inhibitor activity 4.06762092339715 bayes_pls_golite062009
nucleic acid binding 4.02967008021862 bayes_pls_golite062009
DNA binding 3.62735703519187 bayes_pls_golite062009
single-stranded DNA binding 3.59212997362902 bayes_pls_golite062009
structure-specific DNA binding 3.53214384646348 bayes_pls_golite062009
binding 2.83465364476231 bayes_pls_golite062009
transcription regulator activity 2.20239961025491 bayes_pls_golite062009
structural constituent of ribosome 2.13063800565247 bayes_pls_golite062009
structural molecule activity 1.9177190829469 bayes_pls_golite062009
protein binding 1.20309946451799 bayes_pls_golite062009
ribonuclease activity 1.19236946227657 bayes_pls_golite062009
DNA helicase activity 1.12203697857261 bayes_pls_golite062009
transcription factor activity 1.05816813143865 bayes_pls_golite062009
sequence-specific DNA binding 0.86170694706755 bayes_pls_golite062009
DNA-directed RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
RNA polymerase activity 0.79554655100991 bayes_pls_golite062009
DNA-dependent ATPase activity 0.638831894247026 bayes_pls_golite062009
nuclease activity 0.57381531077345 bayes_pls_golite062009
double-stranded DNA binding 0.378383789953688 bayes_pls_golite062009
nucleotidyltransferase activity 0.325774164899685 bayes_pls_golite062009
four-way junction helicase activity 0.31769813397725 bayes_pls_golite062009
translation regulator activity 0.31332179848255 bayes_pls_golite062009
RNA binding 0.31028563542112 bayes_pls_golite062009
exonuclease activity 0.28313884527829 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.263197317040851 bayes_pls_golite062009
translation initiation factor activity 0.2080607201312 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.125256208482441 bayes_pls_golite062009
exoribonuclease activity 0.109774918833391 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.0954216620147701 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.0179535526984695 bayes_pls_golite062009
helicase activity 0.0121541775159524 bayes_pls_golite062009
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