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View Structure Prediction Details

Protein: MDH_BACSU
Organism: Bacillus subtilis
Length: 312 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MDH_BACSU.

Description E-value Query
Range
Subject
Range
gi|89100383, gi|... - gi|89100383|ref|ZP_01173247.1| malate dehydrogenase [Bacillus sp. NRRL B-14911], gi|89084902|gb|EAR6...
325.0 [0..1] [312..1]

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Predicted Domain #1
Region A:
Residues: [1-312]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNTRKKVSV IGAGFTGATT AFLIAQKELA DVVLVDIPQL ENPTKGKALD MLEASPVQGF  60
   61 DAKITGTSNY EDTAGSDIVV ITAGIARKPG MSRDDLVSTN EKIMRSVTQE IVKYSPDSII 120
  121 VVLTNPVDAM TYAVYKESGF PKERVIGQSG VLDTARFRTF VAEELNLSVK DVTGFVLGGH 180
  181 GDDMVPLVRY SYAGGIPLET LIPKERIDAI VERTRKGGGE IVNLLGNGSA YYAPAASLTE 240
  241 MVEAILKDQR RVLPTIAYLE GEYGYEGIYL GVPTIVGGNG LEQIIELELT DYERAQLNKS 300
  301 VESVKNVMKV LS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.0
Match: 1guzA
Description: Malate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
malate dehydrogenase activity 4.38786524125089 bayes_pls_golite062009
oxidoreductase activity 3.09625241707629 bayes_pls_golite062009
L-lactate dehydrogenase activity 2.59062377380589 bayes_pls_golite062009
catalytic activity 1.79741889688267 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 1.70038641098437 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 1.65338499044318 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.47309297191111 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 1.27032644348698 bayes_pls_golite062009
malic enzyme activity 1.2147813077436 bayes_pls_golite062009
retinol dehydrogenase activity 1.16811519855038 bayes_pls_golite062009
L-malate dehydrogenase activity 1.02646414923682 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.99118526697655 bayes_pls_golite062009
binding 0.982999356179965 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.788034697021177 bayes_pls_golite062009
NAD or NADH binding 0.74536049628503 bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent 0.729242797855749 bayes_pls_golite062009
fatty acid synthase activity 0.714637370305282 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.576163737662951 bayes_pls_golite062009
DNA binding 0.525227236870065 bayes_pls_golite062009
protein binding 0.507836099271263 bayes_pls_golite062009
nucleic acid binding 0.459537641913493 bayes_pls_golite062009
coenzyme binding 0.35922330382799 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.216422278300306 bayes_pls_golite062009
signal transducer activity 0.201915860594054 bayes_pls_golite062009
molecular transducer activity 0.201915860594054 bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity 0.192594057004213 bayes_pls_golite062009
transcription regulator activity 0.177044638410302 bayes_pls_golite062009
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity 0.120195861875768 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.0913823272876781 bayes_pls_golite062009

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