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View Structure Prediction Details

Protein: cul-2
Organism: Caenorhabditis elegans
Length: 743 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cul-2.

Description E-value Query
Range		 Subject
Range
gi|50733451 - gi|50733451|ref|XP_418878.1| PREDICTED: similar to Cullin homolog 1 (CUL-1) [Gallus gallus]
 708.0 [0..7] [743..219]

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Predicted Domain #1
Region A:
Residues: [1-743] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYSLKPKVVE FDKVWVQLRP SIIDIINLRP ITNVQWHHKF SDVYDICVSI PTPLSERLYN  60
   61 EVKACIQEHV RQKRQDIVDV DPDLLLQEYH KMWRVFHEGA IFIHRLFGYL NKQFVKQKRC 120
  121 TDLDNFAQYA AFLQIPDVKE IGCLALEIWK EDLVKTILPQ LVKLLLIAID NDRKGNFPHI 180
  181 ANEVSGVINS FVKMEETDFD VVPAEGARYK ARESTTAFYQ ESFEKPLLTD TEQYYSALAQ 240
  241 KMLTDLSCSE YMEQVIVLLE QEEMRAKKYL HESSVEKVIT LCQKVMIKAH KDKLHAVCHD 300
  301 LITNEENKDL RNMYRLLKPI QAGLSVMVKE FEEYVKKKGL EAVSRLTGEN VPQQFVENVL 360
  361 RVYNKFNDMK TAVFMDDGEF SSGLDKALQG VVNSKEPGQS VPKASERLAR YTDGLLKKST 420
  421 KGLSETDLEA KLDSAIVIFR YIEDKDIFQK FYSKMLANRL IASTSISMDA EELMINKLKQ 480
  481 ACGYEFTSKL SRMFTDIGLS QELSNNFDKH IADIKTVQPD VKFVPTQTMI LQPVIQEFEK 540
  541 FYTGKHNGRK LTWLFNMSQG DVRLTYLDKQ YVAQMYVYQM AALLCFERRD AILVKDIGEE 600
  601 IGVSGDYLLK TIRTILDVTL LTCDDQNLTA DSLVRLNMSM TSKRMKFRLQ APQVNKAVEK 660
  661 EQEAVANTFQ VSQDRKYYME CAIVRIMKTR KVLKHNALVT EIMDQTKGRF SPDVPFIKKS 720
  721 IEDLIEKMYI QRTDQNDEYQ YLA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1u6gA
Description: Crystal Structure of The Cand1-Cul1-Roc1 Complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 9.47178230940453 bayes_pls_golite062009
small conjugating protein ligase activity 9.15192834197166 bayes_pls_golite062009
acid-amino acid ligase activity 8.12051073361876 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 6.87003086224111 bayes_pls_golite062009
vasopressin activated calcium mobilizing receptor activity 6.55844152294696 bayes_pls_golite062009
transcription regulator activity 4.76121492612224 bayes_pls_golite062009
transcription factor activity 3.7855017556511 bayes_pls_golite062009
ligase activity 3.66453881539688 bayes_pls_golite062009
transcription repressor activity 2.39237599101586 bayes_pls_golite062009
binding 2.3219000606044 bayes_pls_golite062009
protein binding 2.20237620151495 bayes_pls_golite062009
transcription activator activity 2.05043065144612 bayes_pls_golite062009
nucleic acid binding 1.54797684894025 bayes_pls_golite062009
DNA binding 1.42215436462553 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.23862224095769 bayes_pls_golite062009
transporter activity 0.891050405674973 bayes_pls_golite062009
transmembrane transporter activity 0.648150681919233 bayes_pls_golite062009
transcription factor binding 0.612315945412079 bayes_pls_golite062009
substrate-specific transporter activity 0.368917395770011 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.249771970501337 bayes_pls_golite062009
catalytic activity 0.201606344181603 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.146182977030285 bayes_pls_golite062009
hydrolase activity 0.140191206949582 bayes_pls_golite062009
structure-specific DNA binding 0.117670813298683 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.107671044044222 bayes_pls_golite062009
transferase activity 0.064832527337659 bayes_pls_golite062009
specific transcriptional repressor activity 0.0565989703351002 bayes_pls_golite062009
sequence-specific DNA binding 0.0102780098866235 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle