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View Structure Prediction Details

Protein: ari-1
Organism: Caenorhabditis elegans
Length: 494 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ari-1.

Description E-value Query
Range
Subject
Range
gi|157748007 - gi|157748007|ref|XP_001669098.1| Hypothetical protein CBG20248 [Caenorhabditis briggsae AF16]
gi|187023550, gi... - gi|39580958|emb|CAE72928.1| Hypothetical protein CBG20248 [Caenorhabditis briggsae], gi|187023550|em...
345.0 [0..1] [494..1]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDDEINMD DSDSSQGEID DGCMSDDDGI VLESREQNSS DYKDNGEPDN EVLNHDSLEA  60
   61 EMKKTITDVQ AVLQVKTGVC RILLHKYKWN KESLLERFYE HPDTTTFLID AH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [113-208]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VIPRRQERLP AGDAECDICC SLGELSGLSC NHRACTQCWK AYLTNKIANN AQSEIECMAP  60
   61 NCKLLIEDEK VMFYITDPTV IATYRKLIVA SYVETN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.221849
Match: 2egpA
Description: No description for 2egpA was found.

Predicted Domain #3
Region A:
Residues: [209-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLLKWCPGID CGKAVRVSHW EPRLVVCSCG SRFCFSCGHD WHEPVNCRLL KLWLKKCNDD  60
   61 SETSNWINAN TKEC

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.16
Match: 2ct7A
Description: Solution Structure of the IBR domain of the RING finger protein 31 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.25982737281228 bayes_pls_golite062009
small conjugating protein ligase activity 5.16068345159314 bayes_pls_golite062009
acid-amino acid ligase activity 4.24782814163304 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.79292110382407 bayes_pls_golite062009
binding 2.11628925728357 bayes_pls_golite062009
protein binding 1.50887080730571 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.02238152139385 bayes_pls_golite062009
ubiquitin-specific protease activity 0.821040441472875 bayes_pls_golite062009
nucleic acid binding 0.69956438716198 bayes_pls_golite062009
transcription regulator activity 0.522112597101813 bayes_pls_golite062009
ligase activity 0.424146907469434 bayes_pls_golite062009
cysteine-type peptidase activity 0.356312424125648 bayes_pls_golite062009
DNA binding 0.231306651563916 bayes_pls_golite062009
hydrolase activity 0.185228576891116 bayes_pls_golite062009
catalytic activity 0.168711389690753 bayes_pls_golite062009
peptidase activity 0.107857202210184 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.0136579100966835 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [283-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKCMITIEKD GGCNHMTCKN TACRFEFCWM CLGPWEPHGS SWYSCNR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.69897
Match: 1wd2A
Description: Solution Structure of the C-terminal RING from a RING-IBR-RING (TRIAD) motif
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.65442784325159 bayes_pls_golite062009
small conjugating protein ligase activity 5.55686022186257 bayes_pls_golite062009
acid-amino acid ligase activity 4.59153177011595 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 3.07217714843839 bayes_pls_golite062009
binding 2.19426901055464 bayes_pls_golite062009
protein binding 1.62051249360163 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
nucleic acid binding 0.708499177773075 bayes_pls_golite062009
ligase activity 0.63517530468004 bayes_pls_golite062009
transcription regulator activity 0.553991532499653 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
DNA binding 0.227671243150662 bayes_pls_golite062009
hydrolase activity 0.156835837705934 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
peptidase activity 0.121357659741468 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [330-494]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDDSAAKNAR DAQEVSRANL QRYLFYYNRY MGHQQSLRLE GKLYATVKSK MEQMQTLSMS  60
   61 WIEVQFLRKA VDVLSECRRT LMFTYAFAFY LKRDNNAIIF ESNQKDLEME TEQLSGFLER 120
  121 DLDNENLVTL KQKVQDKYRY VEHRRKVLLD HCSEGADQEL WVFNE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle