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View Structure Prediction Details

Protein: pax-2
Organism: Caenorhabditis elegans
Length: 351 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pax-2.

Description E-value Query
Range
Subject
Range
gi|157759409 - gi|157759409|ref|XP_001672048.1| Hypothetical protein CBG13498 [Caenorhabditis briggsae AF16]
gi|39587883, gi|... - gi|39587883|emb|CAE67901.1| Hypothetical protein CBG13498 [Caenorhabditis briggsae], gi|187028530|em...
308.0 [0..5] [349..18]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTKTFSNNY MTSSQSAYCN LQQYHDSRVC LLKCCRVQKV DPYFPRIALN SATSYPTVSG  60
   61 TVSLPKAETV EPDLWIKSFK GNEDPLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDGSHTGVNQ LGGVFVNGRP LPDTIRAQIV EMSQHGTRPC DISRQLKVSH GCVSKILGRY  60
   61 YSTGSVRPGV IGGSKPKVAT PRVVECIAGY KRANPTMFAW EIRQKLIEDQ ICGEENVPSV 120
  121 SSINRIVRNK SFMAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.69897
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [223-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LATPTSVTPS VARPSSATSQ NQRSPPRGVQ QHMQQSTSVQ QLQQFQLTSA ATVNSLISRP  60
   61 AFAIPGTTHS INGLLGTFPH SSLLDDKFTN LSTHSADMSL VYPTGLVGEH DWAMRTPMVI 120
  121 LPQNYCGQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1fjlA
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle