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View Structure Prediction Details

Protein: pax-2
Organism: Caenorhabditis elegans
Length: 351 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pax-2.

Description E-value Query
Range
Subject
Range
gi|157759409 - gi|157759409|ref|XP_001672048.1| Hypothetical protein CBG13498 [Caenorhabditis briggsae AF16]
gi|39587883, gi|... - gi|39587883|emb|CAE67901.1| Hypothetical protein CBG13498 [Caenorhabditis briggsae], gi|187028530|em...
308.0 [0..5] [349..18]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTKTFSNNY MTSSQSAYCN LQQYHDSRVC LLKCCRVQKV DPYFPRIALN SATSYPTVSG  60
   61 TVSLPKAETV EPDLWIKSFK GNEDPLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [88-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDGSHTGVNQ LGGVFVNGRP LPDTIRAQIV EMSQHGTRPC DISRQLKVSH GCVSKILGRY  60
   61 YSTGSVRPGV IGGSKPKVAT PRVVECIAGY KRANPTMFAW EIRQKLIEDQ ICGEENVPSV 120
  121 SSINRIVRNK SFMAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.69897
Match: 1k78A
Description: Pax-5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [223-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LATPTSVTPS VARPSSATSQ NQRSPPRGVQ QHMQQSTSVQ QLQQFQLTSA ATVNSLISRP  60
   61 AFAIPGTTHS INGLLGTFPH SSLLDDKFTN LSTHSADMSL VYPTGLVGEH DWAMRTPMVI 120
  121 LPQNYCGQL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1fjlA
Description: Paired protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle