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View Structure Prediction Details

Protein: sfa-1
Organism: Caenorhabditis elegans
Length: 699 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sfa-1.

Description E-value Query
Range
Subject
Range
gi|46110397, gi|... - gi|46110397|ref|XP_382256.1| hypothetical protein FG02080.1 [Gibberella zeae PH-1], gi|42546868|gb|E...
303.0 [0..131] [600..1133]

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Predicted Domain #1
Region A:
Residues: [1-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKTGGNTEP MPFIRKWGNE AGEDLGAAPS ATAAPPPALV VPTISSMSSG DNKSPSRSES  60
   61 VSDRKRDRSR SRDRDRKKDR KKKDRSRERD RERRSSRSRS RSPRDRDRER RRRRSRSPPP 120
  121 RRRSRSGGDR RRRER

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [136-259]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPPSMVPNSP QRVKEPVINP LIREDLAAAV ESGAVPVEAV QAGAVVALNP AKKERRSRWS  60
   61 TTKSFVPGMP TILPADLTED QRNAYLLQLE IEDATRKLRL ADFGVAEGRE RSPSPEPVYD 120
  121 ANGK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [260-416]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLNTREVRKR QELEQLRHEK IQALLKINPN FKPPADYRAP NIRLHDKVWI PQEQFPDLNF  60
   61 VGLLIGPRGN TLKSLEAETG AKIIIRGKGS IKEGKLTNRL GPMPGENEPL HAYVTGTDMN 120
  121 VIKKACEKIK QVIAEATALP DNNELRKLQL RELALLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.39794
Match: 1k1gA
Description: RNA splicing factor 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 4.28581120742478 bayes_pls_golite062009
RNA binding 4.07234389285213 bayes_pls_golite062009
binding 3.45962790790935 bayes_pls_golite062009
mRNA binding 2.74771386314615 bayes_pls_golite062009
protein binding 2.21586499514642 bayes_pls_golite062009
transcription regulator activity 2.01194399592256 bayes_pls_golite062009
DNA binding 1.78469836520678 bayes_pls_golite062009
transcription factor activity 0.866815968834173 bayes_pls_golite062009
0.649281624091344 bayes_pls_golite062009
structure-specific DNA binding 0.64468203163713 bayes_pls_golite062009
transcription repressor activity 0.594072241231183 bayes_pls_golite062009
single-stranded DNA binding 0.28490151670131 bayes_pls_golite062009
transcription activator activity 0.210494225017032 bayes_pls_golite062009
transcription factor binding 0.139588254197875 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [417-509]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTFRPEDLAN GARCSNCGSD EHKSWECPDA PNVTNQIKCT NCGAFGHISK DCKNPKGMYA  60
   61 SEAGMDDEYS ALMAELGETP AAGAGAGGGG GGH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.05
Match: 2ihxA
Description: No description for 2ihxA was found.

Predicted Domain #5
Region A:
Residues: [510-699]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VASAGGGISA MTGAGGEAPG GGAGGRGGGA HGGAGRGGGY QGGRGGGRGF QNPRDLFGPP  60
   61 KGEEEQQQQA NASMQHGYYD HYQQYAYPNQ YQQPYGAPAP PGGSAYGHQQ QQQQQQQQDY 120
  121 SDFYTSPGAR GGAGAKANKG WYGSGGGSSM PMPVPPPGGL GGFMPPPPPP PPMPGDLSSL 180
  181 LAAAPPPPPS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1y0fB
Description: No description for 1y0fB was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle