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View Structure Prediction Details

Protein: twk-18
Organism: Caenorhabditis elegans
Length: 461 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for twk-18.

Description E-value Query
Range
Subject
Range
AKT1_ORYSJ - Potassium channel AKT1 OS=Oryza sativa subsp. japonica GN=AKT1 PE=2 SV=1
AKT1_ORYSA - Potassium channel AKT1 (OsAKT1) - Oryza sativa (Rice)
215.0 [0..66] [444..83]

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Predicted Domain #1
Region A:
Residues: [1-186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAIVAQGVST ILTTFQKTFK GLLPLIILVA YTLLGAWIFW MIEGENEREM LIEQQKERDE  60
   61 LIRRTVYKIN QLQIKRQRRL MTAEEEYNRT AKVLTTFQET LGIVPADMDK DIHWTFLGSI 120
  121 FYCMTVYTTI GYGNIVPGTG WGRFATILYA FIGIPLTVLS LYCLGSLFAK GCKMLWRFFL 180
  181 KSTRVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.69897
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [187-461]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDLSNKISE AADNIEEGTT AITPSAEKTE NNDDDLLSFP ISGLLLITVI WVIFCAVLFT  60
   61 FLEEWDFGTS LYFTLISFTT IGFGDILPSD YDFMPIVGVL LLIGLSLVST VMTLIQQQIE 120
  121 ALASGMKDNI DQEYARALNE AREDGEVDEH VDPEEDPENN KKSFDAVISR MNWSKRGLYY 180
  181 LLPDSQKKEL AKQSEKKMGR KSIKIQTDND LLETLIREEI LKAELNNEMH KYTAPRSSHQ 240
  241 PKLVYSDVRE KEVPIEVVRV EHFNHGNEDY LEHDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.221849
Match: 1p7bA
Description: Inward rectifier potassium channel Kirbac1.1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
potassium channel activity 6.4331378592544 bayes_pls_golite062009
voltage-gated potassium channel activity 6.39751759555879 bayes_pls_golite062009
voltage-gated cation channel activity 6.27599868772094 bayes_pls_golite062009
voltage-gated ion channel activity 6.14572423982603 bayes_pls_golite062009
voltage-gated channel activity 6.13745115468656 bayes_pls_golite062009
metal ion transmembrane transporter activity 5.06264960439093 bayes_pls_golite062009
cation transmembrane transporter activity 4.86252983188139 bayes_pls_golite062009
ion transmembrane transporter activity 4.77144021609018 bayes_pls_golite062009
cation channel activity 4.45742516382134 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.3961579058414 bayes_pls_golite062009
inward rectifier potassium channel activity 4.13359972196575 bayes_pls_golite062009
ion channel activity 3.86720832958006 bayes_pls_golite062009
gated channel activity 3.81381731911499 bayes_pls_golite062009
substrate-specific channel activity 3.76052840244313 bayes_pls_golite062009
passive transmembrane transporter activity 3.7587607940377 bayes_pls_golite062009
channel activity 3.7587607940377 bayes_pls_golite062009
transporter activity 2.93091397928047 bayes_pls_golite062009
transmembrane transporter activity 2.82224868778929 bayes_pls_golite062009
G-protein activated inward rectifier potassium channel activity 2.75125247009886 bayes_pls_golite062009
substrate-specific transporter activity 2.54207434157938 bayes_pls_golite062009
ATP-activated inward rectifier potassium channel activity 2.06424227369337 bayes_pls_golite062009
ligand-gated ion channel activity 1.70106533585704 bayes_pls_golite062009
ligand-gated channel activity 1.70106533585704 bayes_pls_golite062009
binding 1.53091146101223 bayes_pls_golite062009
protein binding 1.48353517714382 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle