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View Structure Prediction Details

Protein: atg-4.2
Organism: Caenorhabditis elegans
Length: 521 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for atg-4.2.

Description E-value Query
Range
Subject
Range
gi|149020504, gi... - gi|210032083|ref|NP_001094483.2| autophagy-related 4D [Rattus norvegicus], gi|149020504|gb|EDL78309....
524.0 [0..41] [511..12]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNIPDDFKK IASSSRLPRK YCSSESSLSD DDGHEIEHVL KHGAPEEALT PDTERMVVLG  60
   61 QDVVQSAPAS LVPGGNLSWM SKIKSAGASM MGSIRPSSSS QDVHSTGEIE KHSKKKWKAR 120
  121 LWSTWNNIKY S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [132-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STWMSDRSDE YGGENDVVFL GRRYSTSVDE SGLRSGFENF CSDYYSRLWI TYRTDFPALL  60
   61 DTDTTTDCGW GCMIRTTQMM VAQAIMVNRF GRDWRFTRRK RSHVAAHGDE DDFDREKIQE 120
  121 WMILKLFEDK PTAPLGIHKM VGIAAMGKGK KAVGSWYSPS EAVFIMKKAL TESSSPLTGN 180
  181 TAMLLSIDGR VHIRDIEVET KNWMKKLILV IVVRLGAAEL NPIYVPHLMR LFAMESCLGI 240
  241 TGGRPDHSSW FVGYYGDQII YLDPHVAHEY IPIDINPNTN VVDSDSKKAK KCPEKSYHCR 300
  301 LLSKMHFFDM DPSCALCFQF ESREQFDNDM RQLNLSQFID IDQGEEHGMK RVRDPMFSVV 360
  361 YGERRQPPSY EREVSETEQA QADKHGFEML 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 126.0
Match: 2d1iA
Description: Structure of human Atg4b
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.90619850296986 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.64381885397949 bayes_pls_golite062009
endopeptidase activity 3.75054525912786 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
hydrolase activity 2.66167923792227 bayes_pls_golite062009
cytoskeletal protein binding 2.13397229861051 bayes_pls_golite062009
small conjugating protein-specific protease activity 2.06332547782769 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
tubulin binding 1.85112496470487 bayes_pls_golite062009
microtubule binding 1.82320858139311 bayes_pls_golite062009
binding 1.77258741259391 bayes_pls_golite062009
ubiquitin-specific protease activity 1.43988355875744 bayes_pls_golite062009
protein binding 1.08139200376412 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
nucleic acid binding 0.913227912866975 bayes_pls_golite062009
transporter activity 0.69523261160023 bayes_pls_golite062009
DNA binding 0.683141655614916 bayes_pls_golite062009
transcription regulator activity 0.667279936700542 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
transmembrane transporter activity 0.439003000540428 bayes_pls_golite062009
structural molecule activity 0.297752217869698 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
substrate-specific transporter activity 0.125654358663332 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0241561776323942 bayes_pls_golite062009
transcription factor activity 0.0199148741009585 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle