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View Structure Prediction Details

Protein: CE19992
Organism: Caenorhabditis elegans
Length: 589 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE19992.

Description E-value Query
Range		 Subject
Range
FYN_XIPHE - Tyrosine-protein kinase Fyn OS=Xiphophorus helleri GN=fyn PE=2 SV=3
 373.0 [0..2] [450..88]

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Predicted Domain #1
Region A:
Residues: [1-455] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKRNDSTNP RIYGSALRKK ESTQDLQFGE NSDGHQVSSD QLSETHSIGA SQVAGNYETE  60
   61 KLEEMYISHV LKFYPWYHGM MFGQTVEKLL KWDYAYLVRR AMQRNSKKVL CLSVKIDGKI 120
  121 CHFTLNSNKD GWSCGKLLAK FPKITPKRFQ HIHHLLDAWS LVVNSIVPVP RRQLVLQHNC 180
  181 IHLENILGNG AFGEVLKARY IPRGHTNGVE VAVKRVIGTA QREQMQEFCH EAQIMGTLKH 240
  241 DNVVKLYGIA SLEQPIMLVM ELITGGDLKK YLQSTPSIPN RQLIAFALDI ANGMRHLVIK 300
  301 KVIHRDLAAR NCLISRPTLQ VKISDFGLAV QATEVIVKKL SKAPTRWLAP ETFQKGIFNE 360
  361 KTDVWSFGVV LTEILTRCAA DPLAPRTLEE CKKYIIESPH PHRIENKEPK ELAELVEMCC 420
  421 DKNTMCRANF QNAKRRLKIV IDQYDHPDGH KLELK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 100.0
Match: 1fmkA
Description: CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 5.4586557943719 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.04467222534257 bayes_pls_golite062009
kinase activity 4.85903980916957 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63692708178478 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
transferase activity 3.26787750561728 bayes_pls_golite062009
epidermal growth factor receptor binding 2.9751846707539 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.66669268613198 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
vinculin binding 1.63216315345235 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
insulin receptor substrate binding 0.74324450025139 bayes_pls_golite062009
transporter activity 0.710766490066447 bayes_pls_golite062009
MAP kinase kinase activity 0.610230065465794 bayes_pls_golite062009
transmembrane transporter activity 0.60324822483033 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
substrate-specific transporter activity 0.385603245903806 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 0.349343975617553 bayes_pls_golite062009
phosphoinositide 3-kinase binding 0.33808087202461 bayes_pls_golite062009
kinase binding 0.26752427107238 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.152203945257581 bayes_pls_golite062009
cell adhesion molecule binding 0.150740450460731 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
protein kinase binding 0.00674998152095019 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [456-589] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSEEQKRLTI RRSTATVTRK KSRDGGRQAS VERKGHGTQR KVVSVLRKDK GALKLPSGIA  60
   61 TNLERPSPPS HTAKSHTVKS PMTPPVSQPP VSQPPVSQPP VSQPPVSQPP VSQPPVPQHP 120
  121 MTPPPASSAR PHPK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.39794
Match: 2acxA
Description: No description for 2acxA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle