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View Structure Prediction Details

Protein: aph-2
Organism: Caenorhabditis elegans
Length: 721 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for aph-2.

Description E-value Query
Range
Subject
Range
gi|67969014 - gi|67969014|dbj|BAE00862.1| unnamed protein product [Macaca fascicularis]
758.0 [0..3] [715..19]

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Predicted Domain #1
Region A:
Residues: [1-195]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKWLVIVLI IAGIRCDGFS DQVFRTLFIG EGNACYRTFN KTHEFGCQAN RENENGLIVR  60
   61 IDKQEDFKNL DSCWNSFYPK YSGKYWALLP VNLIRRDTIS QLKSSKCLSG IVLYNSGESI 120
  121 HPGDESTAAS HDAECPNAAS DYYLQDKNEE YCERKINSRG AITRDGLMKI DWRIQMVFID 180
  181 NSTDLEIIEK CYSMF

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [196-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKPKEDGSSG YPYCGMSFRL ANMAAGNSEI CYRRGKNDAK LFQMNIDSGD APQLCGAMHS  60
   61 DNIFAFPTPI PTSPTNETII TSKYMMVTAR MDSFGMIPEI SVGEVSVLTS IISVLAAARS 120
  121 MGTQIEKWQK ASNTSNRNVF FAFFNGESLD YIGSGAAAYQ MENGKFPQMI RSDRTHIHPI 180
  181 RPNELDYILE VQQIGVAKGR KYYVHVDGER YQQNKTQTDR VIDRIERGLR SHAFDLEKPS 240
  241 GSGDRVPPAS WHSFAKADAH VQSVLLAPYG KEYEYQRVNS ILDKNEWTED EREKAIQEIE 300
  301 AVSTAILAAA ADYVGVETDE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.0
Match: 1cp7A
Description: Aminopeptidase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.69852272549237 bayes_pls_golite062009
hydrolase activity 4.23257784904124 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.21193944512431 bayes_pls_golite062009
metallopeptidase activity 2.04062448553328 bayes_pls_golite062009
exopeptidase activity 1.5759162922092 bayes_pls_golite062009
catalytic activity 1.3989281287879 bayes_pls_golite062009
binding 0.899461642061592 bayes_pls_golite062009
carboxypeptidase activity 0.891655769761122 bayes_pls_golite062009
endopeptidase activity 0.529831416345723 bayes_pls_golite062009
metalloexopeptidase activity 0.472688733072762 bayes_pls_golite062009
nucleic acid binding 0.385009026435495 bayes_pls_golite062009
metallocarboxypeptidase activity 0.180859448845431 bayes_pls_golite062009
transcription regulator activity 0.140274984043468 bayes_pls_golite062009
aminopeptidase activity 0.0966237570696103 bayes_pls_golite062009
protein binding 0.00854198798870509 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [516-721]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVAKVDKKLI TTIFDCLITS NFWFDCDFMQ KLDGGRYHKL FNSYGFNQKS TYISMESHTA  60
   61 FPTVLHWLTI FALGSDKETL NVKSEKSCSH LGQFQAMYTY TWQPNPYTGN FSCLKSAIVK 120
  121 KVMVSPAVDS QTPEEEMNTR YSTWMESVYI IESVNLYLME DASFEYTMIL IAVISALLSI 180
  181 FAVGRCSETT FIVDEGEPAA EGGEPL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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