| Protein: | plc-4 |
| Organism: | Caenorhabditis elegans |
| Length: | 751 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for plc-4.
| Description | E-value | Query Range |
Subject Range |
|
|
636.0 | [0..14] | [749..8] |
|
Region A: Residues: [1-149] |
1 11 21 31 41 51
| | | | | |
1 MAKSVSPEEQ AAAQAADEEK TKEELEWAEK GSLLCRIKNQ KVKEMALVTI KSKQFLNYYS 60
61 SYWFNFVPNA LKSVALSELL EVRSGYQTDN LQRASKKYEF QELAPESRCF SVIFSHAKFL 120
121 HKSVDFSADS KETRDKWVSV LTHLISVAK
|
| Detection Method: |  |
| Confidence: | 23.0 |
| Match: | 1maiA |
| Description: | STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| SH2 domain binding | 3.65625799344693 | bayes_pls_golite062009 |
| binding | 3.29080729281876 | bayes_pls_golite062009 |
| protein binding | 3.17213698546013 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.88942227773914 | bayes_pls_golite062009 |
| insulin receptor binding | 1.93662993549038 | bayes_pls_golite062009 |
| transcription regulator activity | 1.57653457217606 | bayes_pls_golite062009 |
| nucleic acid binding | 1.35724984140766 | bayes_pls_golite062009 |
| DNA binding | 1.35019502849174 | bayes_pls_golite062009 |
| signal transducer activity | 1.34134699517825 | bayes_pls_golite062009 |
| molecular transducer activity | 1.34134699517825 | bayes_pls_golite062009 |
| transporter activity | 1.28986800087234 | bayes_pls_golite062009 |
| enzyme binding | 1.17212675145623 | bayes_pls_golite062009 |
| receptor activity | 1.02045773197699 | bayes_pls_golite062009 |
| transmembrane receptor activity | 0.990048359575281 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.893216890968741 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.79883446648737 | bayes_pls_golite062009 |
| receptor binding | 0.57115269387131 | bayes_pls_golite062009 |
| protein domain specific binding | 0.51731521446502 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.36659178919568 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.355387992614734 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.335498703113274 | bayes_pls_golite062009 |
| actin binding | 0.2957828973861 | bayes_pls_golite062009 |
| protein complex binding | 0.22543440052247 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.189879136353541 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.00282726023356339 | bayes_pls_golite062009 |
|
Region A: Residues: [150-751] |
1 11 21 31 41 51
| | | | | |
1 HQRVVFNETA WLIDKFQQAD TNKNGLLSFD EVWNLLKRMN LQISERYAKA IFRESEFENS 60
61 RDNKLNEKEF LNFFERLTDR PDLRFVMTQA SSDNVETLTV ADLQRFLTEE QGFENVDLKK 120
121 AEQILTTFEQ TVQDKQKEKL MGLMGMRRLM QSRWGNVFKP GHESIFQDMD QPLTHYFVNS 180
181 SHNTYLTGLQ VKGEATVEGY ISALRKGARL LELDLFDGEH GEPVITHKRT FIESITLRNS 240
241 LEAIKRTAFE TSPYPVILTL ENHVGFVQQA VMADLFKEIL GDSLYIPPKD SHRHPLSSPN 300
301 KLKRKFLLRG KKIILEEDIE EPDEDDSPTD KDKHHVHPHP VAPELSALIG LPSVKLSHNI 360
361 YQDVNKHPFD GSPSLSENKV YTMFEAAVPI FTYTAERLVK SYPKGLRQDS SNMHPMVSWL 420
421 CGIQSVAMNF QTAGEELDLN AGLFRINGNC GYVLKPSCLL DGVDPRSMAK PKLKLGIGLF 480
481 SAQYLPKSEP GKEIIDPYVS VQIFGIPRDE TKAKTRIIKD NGFNPEWRDN FYFTLSCPEL 540
541 AIIRFCVKDF DSTSSNDFVG EFSIPVMSLR TGFSQIQLNT GYQHTLDPSA SLFVRIAMEE 600
601 EY
|
| Detection Method: | |
| Confidence: | 152.0 |
| Match: | 1djgA |
| Description: | Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| inositol or phosphatidylinositol phosphodiesterase activity | 6.15718686264587 | bayes_pls_golite062009 |
| phosphoinositide phospholipase C activity | 6.15718686264587 | bayes_pls_golite062009 |
| phosphoric diester hydrolase activity | 3.98600273089157 | bayes_pls_golite062009 |
| transcription regulator activity | 1.70224798223084 | bayes_pls_golite062009 |
| phospholipase C activity | 1.69567069819233 | bayes_pls_golite062009 |
| binding | 1.68488937304436 | bayes_pls_golite062009 |
| hydrolase activity | 1.52158542563317 | bayes_pls_golite062009 |
| protein binding | 1.44033231686342 | bayes_pls_golite062009 |
| nucleic acid binding | 1.33654529506691 | bayes_pls_golite062009 |
| DNA binding | 1.3098416020159 | bayes_pls_golite062009 |
| catalytic activity | 1.22328099675039 | bayes_pls_golite062009 |
| transporter activity | 1.15928534291452 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 1.11279017101076 | bayes_pls_golite062009 |
| phospholipase activity | 0.964221011759725 | bayes_pls_golite062009 |
| molecular transducer activity | 0.949608579595809 | bayes_pls_golite062009 |
| signal transducer activity | 0.949608579595809 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.945691505472547 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 0.936568622355831 | bayes_pls_golite062009 |
| amine transmembrane transporter activity | 0.717054504236607 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.693724160233023 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.45412801027969 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.37583220367244 | bayes_pls_golite062009 |
| lipase activity | 0.254072795277849 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.246383459363256 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.193201281459889 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 0.0305250212662123 | bayes_pls_golite062009 |
