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Protein Overview: plc-4

General Information:
Name(s) found: plc-4 / CE07421 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00004039 locus:plc-4 status:Confirmed UniProt:Q21754 protein_id:CCD71557.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 751 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: signal transduction [IEALink to PubMed article]
    lipid metabolic process [IEALink to PubMed article]
    Molecular Function: phosphoinositide phospholipase C activity [IEALink to PubMed article]
    phospholipase C activity [IEALink to PubMed article]
    calcium ion binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKSVSPEEQ AAAQAADEEK TKEELEWAEK GSLLCRIKNQ KVKEMALVTI KSKQFLNYYS  60
   61 SYWFNFVPNA LKSVALSELL EVRSGYQTDN LQRASKKYEF QELAPESRCF SVIFSHAKFL 120
  121 HKSVDFSADS KETRDKWVSV LTHLISVAKH QRVVFNETAW LIDKFQQADT NKNGLLSFDE 180
  181 VWNLLKRMNL QISERYAKAI FRESEFENSR DNKLNEKEFL NFFERLTDRP DLRFVMTQAS 240
  241 SDNVETLTVA DLQRFLTEEQ GFENVDLKKA EQILTTFEQT VQDKQKEKLM GLMGMRRLMQ 300
  301 SRWGNVFKPG HESIFQDMDQ PLTHYFVNSS HNTYLTGLQV KGEATVEGYI SALRKGARLL 360
  361 ELDLFDGEHG EPVITHKRTF IESITLRNSL EAIKRTAFET SPYPVILTLE NHVGFVQQAV 420
  421 MADLFKEILG DSLYIPPKDS HRHPLSSPNK LKRKFLLRGK KIILEEDIEE PDEDDSPTDK 480
  481 DKHHVHPHPV APELSALIGL PSVKLSHNIY QDVNKHPFDG SPSLSENKVY TMFEAAVPIF 540
  541 TYTAERLVKS YPKGLRQDSS NMHPMVSWLC GIQSVAMNFQ TAGEELDLNA GLFRINGNCG 600
  601 YVLKPSCLLD GVDPRSMAKP KLKLGIGLFS AQYLPKSEPG KEIIDPYVSV QIFGIPRDET 660
  661 KAKTRIIKDN GFNPEWRDNF YFTLSCPELA IIRFCVKDFD STSSNDFVGE FSIPVMSLRT 720
  721 GFSQIQLNTG YQHTLDPSAS LFVRIAMEEE Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] PSI-BLAST 23.0 STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN FROM PHOSPHOLIPASE C DELTA IN COMPLEX WITH INOSITOL TRISPHOSPHATE
    2 View Details [150..751] PSI-BLAST 152.0 Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!); PI-specific phospholipase C isozyme D1 (PLC-D1), C-terminal domain; Phospholipase C isozyme D1 (PLC-D1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SH2 domain binding
    		•  3.65625799344693 bayes_pls_golite062009
  • binding
    		•  3.29080729281876 bayes_pls_golite062009
  • protein binding
    		•  3.17213698546013 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.88942227773914 bayes_pls_golite062009
  • insulin receptor binding
    		•  1.93662993549038 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.57653457217606 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.35724984140766 bayes_pls_golite062009
  • DNA binding
    		•  1.35019502849174 bayes_pls_golite062009
  • signal transducer activity
    		•  1.34134699517825 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.34134699517825 bayes_pls_golite062009
  • transporter activity
    		•  1.28986800087234 bayes_pls_golite062009
  • enzyme binding
    		•  1.17212675145623 bayes_pls_golite062009
  • receptor activity
    		•  1.02045773197699 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.990048359575281 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.893216890968741 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.79883446648737 bayes_pls_golite062009
  • receptor binding
    		•  0.57115269387131 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.51731521446502 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.36659178919568 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • actin binding
    		•  0.2957828973861 bayes_pls_golite062009
  • protein complex binding
    		•  0.22543440052247 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.189879136353541 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.00282726023356339 bayes_pls_golite062009
    2
    Term Confidence Notes
  • inositol or phosphatidylinositol phosphodiesterase activity
    		•  6.15718686264587 bayes_pls_golite062009
  • phosphoinositide phospholipase C activity
    		•  6.15718686264587 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  3.98600273089157 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.70224798223084 bayes_pls_golite062009
  • phospholipase C activity
    		•  1.69567069819233 bayes_pls_golite062009
  • binding
    		•  1.68488937304436 bayes_pls_golite062009
  • hydrolase activity
    		•  1.52158542563317 bayes_pls_golite062009
  • protein binding
    		•  1.44033231686342 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.33654529506691 bayes_pls_golite062009
  • DNA binding
    		•  1.3098416020159 bayes_pls_golite062009
  • catalytic activity
    		•  1.22328099675039 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.11279017101076 bayes_pls_golite062009
  • phospholipase activity
    		•  0.964221011759725 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.949608579595809 bayes_pls_golite062009
  • signal transducer activity
    		•  0.949608579595809 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.936568622355831 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.717054504236607 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.45412801027969 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.37583220367244 bayes_pls_golite062009
  • lipase activity
    		•  0.254072795277849 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.193201281459889 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0305250212662123 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle