YRC Public Data Repository - Protein Structure Prediction

Protein:	vas1
Organism:	Schizosaccharomyces pombe
Length:	950 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vas1.

Description	E-value	Query Range	Subject Range
gi\|94415871, gi\|... - gi\|94415871\|ref\|ZP_01295706.1\| hypothetical protein PaerP_01002441 [Pseudomonas aeruginosa PA7], gi\|...	820.0	[0..27]	[948..1]
SYV_ALCBS - Valine--tRNA ligase OS=Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2) ...	819.0	[0..27]	[949..3]
SYV_METCA - Valyl-tRNA synthetase OS=Methylococcus capsulatus GN=valS PE=3 SV=1 SYV_METCA - Valine--tRNA ligase OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=valS PE=...	817.0	[0..27]	[949..1]
gi\|67153804, gi\|... - gi\|67153804\|ref\|ZP_00415549.1\| Valyl-tRNA synthetase, class Ia [Azotobacter vinelandii AvOP], ref\|ZP... gi\|67153804, gi\|... - gi\|67153804\|ref\|ZP_00415549.1\| Valyl-tRNA synthetase, class Ia [Azotobacter vinelandii AvOP], gi\|670...	817.0	[0..27]	[948..1]
SYV_PSEAE - Valyl-tRNA synthetase OS=Pseudomonas aeruginosa GN=valS PE=3 SV=1 SYV_PSEAE - Valine--tRNA ligase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) ...	817.0	[0..27]	[948..1]
gi\|95112402 - gi\|95112402\|emb\|CAK17129.1\| valyl-tRNA synthetase [Pseudomonas] gi\|95112402, gi\|... - gi\|95112402\|emb\|CAK17129.1\| valyl-tRNA synthetase [Pseudomonas entomophila L48], gi\|104783415\|ref\|YP...	817.0	[0..27]	[948..1]
SYV_CARHZ - Valine--tRNA ligase OS=Carboxydothermus hydrogenoformans (strain ATCC BAA-161 / DSM 6008 / Z-2901) G...	816.0	[0..26]	[945..4]
gi\|107103354 - gi\|107103354\|ref\|ZP_01367272.1\| hypothetical protein PaerPA_01004423 [Pseudomonas aeruginosa PACS2]	816.0	[0..27]	[948..1]
gi\|116051862, gi... - gi\|32038982\|ref\|ZP_00137254.1\| COG0525: Valyl-tRNA synthetase [Pseudomonas aeruginosa UCBPP-PA14], g...	815.0	[0..27]	[948..1]
SYV_CUPPJ - Valine--tRNA ligase OS=Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) GN=valS PE=3 SV=1	815.0	[0..24]	[948..5]

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Predicted Domain #1

Region A:
Residues: [1-950]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFHFQRSFSS RKAHGLLSFK NRNYIHIEAP FDIAAIQDGW NIIRKHIHYP KPKSIEAPMF  60
   61 PILLPPPNIT GKLHIGHALT ITIQDALARF YAMHGYKVSF RPGTDHAGIA TQSVVEKYLQ 120
  121 KKGVYRNQLS KDELLSSIHS WQVKYQKSII NQLKSFEAIF DWDNIFYTMD QNRSEAVNEA 180
  181 FISLFNAGLI YRANRFVNWC PKLESAVSDI EVESQQINKP VTKYVDNTPV EFGWLYEISY 240
  241 QLEGSDNEQL NVSTTRPETI FGDRAIAVSP HDERYKKYVG RFVKHPLIDD LLIPVICDNA 300
  301 VDRHFGTGVL KITPMHSIVD YEIAKRHNID CVSIMDKSGN LINCSKEVNG MNRLKARSKI 360
  361 VRLLQQRNRL VEQVPHSLIL SVCSRTGDVI EPVMVPQWYL SVDSLKKEVL KSSNKLKLVP 420
  421 SLARKEWDSW FKKMGDWCIS RQIWWGHQIP VWKILEEDKW IAAPNYEKAL QLSVGKSVSQ 480
  481 DSDVLDTWFS SALLPLSAFG WPKSKDIQPL PFIESGQDIL FFWIARMALL CKYFSNELPF 540
  541 KEIILHPLVR DSEGRKMSKS LGNVIDPMDI INGVTLENMK KALLEGNLPI SEVHKSSKQM 600
  601 EKAFPNGIPA QGIDIFRYGL FLCLHHEQRI LLDMNSFSDA HRFVSKLWNL ARYFNQYKDK 660
  661 ENPLKLTDSQ RQRISLLKMA TYSKLHHAVE GVKESFEQRK FFNAADIMKN FLLNDLSSVY 720
  721 VELTRFDVKD SKSSAYEVYR VFSDILHIFL KLIHPIVPCI SGVMLHSKII PERKNSEFLS 780
  781 FPTSQQECLL VHDNQAEVVV QNAYDVLIQL RKLESPLNKS PSREHTVYIS TSLEPLKYFY 840
  841 DAIEQSTNLK LKSISQEDTI DLMRNQTFIL SRISSDTILL VPKKLYPSKR KKLRKNLDDL 900
  901 QKKLDKIQHT TSSSGYEKAP SYIKLKNCEL QKDILVKIQD IKQALLNTEI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1gaxA
Description:	Valyl-tRNA synthetase (ValRS) C-terminal domain; Valyl-tRNA synthetase (ValRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
valine-tRNA ligase activity	7.13767629265822	bayes_pls_golite062009
leucine-tRNA ligase activity	7.03538514482698	bayes_pls_golite062009
isoleucine-tRNA ligase activity	6.38633897147986	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
methionine-tRNA ligase activity	2.56893064485672	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.88984817882585	bayes_pls_golite062009
arginine-tRNA ligase activity	1.50161401062914	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.844943947059557	bayes_pls_golite062009
binding	0.485102284225571	bayes_pls_golite062009
nucleic acid binding	0.449504767632354	bayes_pls_golite062009
nucleotidyltransferase activity	0.2293846471193	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.126511747475258	bayes_pls_golite062009
glutamine-tRNA ligase activity	0.118292082006187	bayes_pls_golite062009
mRNA binding	2.82524485163416E-5	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: