YRC Public Data Repository - Protein Structure Prediction

Protein:	arg4
Organism:	Schizosaccharomyces pombe
Length:	1160 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for arg4.

Description	E-value	Query Range	Subject Range
r-PA, FBpp030914... - The gene rudimentary is referred to in FlyBase by the symbol Dmel\r (CG18572, FBgn0003189). It is a ...	1038.0	[0..19]	[1137..324]
gi\|191333 - gi\|191333\|gb\|AAA37062.1\| carbamoyl-phosphate synthetase (E.C.6.3.5.5)	1029.0	[0..1]	[1130..142]
CARB_NEIMA - Carbamoyl-phosphate synthase large chain OS=Neisseria meningitidis serogroup A / serotype 4A (strain... CARB_NEIMA - Carbamoyl-phosphate synthase large chain OS=Neisseria meningitidis serogroup A GN=carB PE=3 SV=1 gi\|11272704 - pir\|\|F81979 carbamoyl-phosphate synthase (glutamine-hydrolyzing) (EC 6.3.5.5) large chain NMA0602 [i...	1025.0	[0..80]	[1149..1]
gi\|109478988 - gi\|109478988\|ref\|XP_001063872.1\| PREDICTED: similar to carbamoyl-phosphate synthetase 2, aspartate t...	1024.0	[0..1]	[1130..297]
gi\|104780016, gi... - gi\|95109003\|emb\|CAK13699.1\| carbamoyl-phosphate synthase, large subunit [Pseudomonas entomophila L48... gi\|95109003 - gi\|95109003\|emb\|CAK13699.1\| carbamoyl-phosphate synthase, large subunit [Pseudomonas entomophila L48...	1024.0	[0..80]	[1150..1]
tr\|E4R632\|E4R632... - Carbamoyl-phosphate synthase large chain OS=Pseudomonas putida (strain BIRD-1) GN=carB PE=3 SV=1 gi\|24986476, gi\|... - gi\|26991406\|ref\|NP_746831.1\| carbamoyl-phosphate synthase large subunit [Pseudomonas putida KT2440],...	1023.0	[0..80]	[1150..4]
gi\|82737627, gi\|... - gi\|82737627\|ref\|ZP_00900474.1\| Carbamoyl-phosphate synthase, large subunit, glutamine-dependent [Pse...	1023.0	[0..80]	[1150..1]
gi\|77380997, gi\|... - gi\|77456994\|ref\|YP_346499.1\| carbamoyl phosphate synthase large subunit [Pseudomonas fluorescens Pf0...	1023.0	[0..80]	[1150..1]

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Predicted Domain #1

Region A:
Residues: [1-1160]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALWATSMRR AIPGISKAFL GSNRVLETAG VSQLSKHLLP QWSGVPHRKI SASATNFNDK  60
   61 VKESNTPDAN AYIRSGHIKA AEHEKVKKVV VVGSGGLSIG QAGEFDYSGA QAIKALRESS 120
  121 VHTILINPNI ATIQSSHSLA DEIYFLPVTA EYLTHLIERE NPDGILLTFG GQTALNVGIQ 180
  181 LDDMGVFARN HVKVLGTPIS TLKTSEDRDL FAKALNEINI PIAESVAVST VDEALQAAEK 240
  241 VSYPVIIRSA YSLGGLGSGF ANNKEELQSM AAKSLSLTPQ ILVEKSLKGW KEVEYEVVRD 300
  301 AANNCITVCN MENFDPLGIH TGDSIVVAPS QTLSDEEYHM LRTAAIKIIR HLGVVGECNV 360
  361 QYALSPNSLE YRVIEVNARL SRSSALASKA TGYPLAYTAA KIALGHTLPE LPNAVTKTTT 420
  421 ANFEPSLDYV VTKIPRWDLS KFQYVNREIG SSMKSVGEVM AVGRTFEESL QKALRQVDPS 480
  481 FLGFMAMPFK DLDNALSVPT DRRFFAVVEA MLNQGYSIDK IHDLTKIDKW FLSKLANMAK 540
  541 VYKELEEIGS LYGLNKEIML RAKKTGFSDL QISKLVGASE LDVRARRKRL DVHPWVKKID 600
  601 TLAAEFPAHT NYLYTSYNAS SHDIDFNEHG TMVLGSGVYR IGSSVEFDWC GVSCARTLRK 660
  661 LGHSTIMVNY NPETVSTDFD ECERLYFEEL SYERVMDIYE METASGIVVS VGGQLPQNIA 720
  721 LKLQETGAKV LGTDPLMIDS AEDRHKFSQI LDKIGVDQPA WKELTSVAEA SKFANAVGYP 780
  781 VLVRPSYVLS GAAMSVIRDE SSLKDKLENA SAVSPDHPVV ITKFIEGARE LDVDAVASKG 840
  841 KLLVHAVSEH VENAGVHSGD ATIALPPYSL SEDILSRCKE IAEKVCKAFQ ITGPYNMQII 900
  901 LAQNPDKPDT PDLKVIECNL RASRSFPFVS KTLGVNFIDV ATRSIIDQEV PAARDLMAVH 960
  961 RDYVCVKVPQ FSWTRLAGAD PYLGVEMSST GEVACFGKDV KEAYWAALQS TQNFKIPLPG1020
 1021 QGILLGGDRP ELAGIAADLS KLGYKLYVAN KDAAKLLQPT SAEVVEFPVK DKRALRAIFE1080
 1081 KYNIRSVFNL ASARGKNVLD QDYVMRRNAV DFNVTLINDV NCAKLFVESL KEKLPSVLSE1140
 1141 KKEMPSEVKR WSEWIGSHDL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1bxrA
Description:	Carbamoyl phosphate synthetase, large subunit connection domain; Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain; Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains; Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbamoyl-phosphate synthase activity	10.3961907577933	bayes_pls_golite062009
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	10.3817460390594	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	7.55690629692775	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	6.95559501787172	bayes_pls_golite062009
ligase activity	1.91091941710895	bayes_pls_golite062009
phosphoribosylaminoimidazole carboxylase activity	1.57708889650281	bayes_pls_golite062009
catalytic activity	1.08688404807699	bayes_pls_golite062009
phosphoribosylamine-glycine ligase activity	1.04915286326924	bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates	0.964679554894316	bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity	0.898425265043358	bayes_pls_golite062009
acid-amino acid ligase activity	0.730894973410499	bayes_pls_golite062009
carbon-oxygen lyase activity	0.482425669839603	bayes_pls_golite062009
lyase activity	0.432948879967458	bayes_pls_golite062009
ligase activity, forming carbon-sulfur bonds	0.37779550230552	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	0.2431211195117	bayes_pls_golite062009
glutathione synthase activity	0.0685848191991462	bayes_pls_golite062009
biotin carboxylase activity	0.0172732430077291	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: