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View Structure Prediction Details

Protein: SPAC23C4.03
Organism: Schizosaccharomyces pombe
Length: 488 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC23C4.03.

Description E-value Query
Range		 Subject
Range
gi|29849 - gi|29849|emb|CAA43807.1| CDK2 [Homo sapiens]
 264.0 [0..154] [480..2]
gi|117499872 - gi|117499872|gb|ABK34941.1| cyclin-dependent kinase 2 [Capra hircus]
gi|215983068, gi... - gi|215983068|ref|NP_001135981.1| cyclin-dependent kinase 2 [Ovis aries], gi|213688920|gb|ACJ53943.1|...
CDK2_BOVIN - Cyclin-dependent kinase 2 OS=Bos taurus GN=CDK2 PE=2 SV=1
 264.0 [0..154] [480..2]
CDK2_RAT - Cyclin-dependent kinase 2 OS=Rattus norvegicus GN=Cdk2 PE=1 SV=1
gi|710025 - gi|710025|dbj|BAA05947.1| cyclin dependent kinase 2-alpha [Rattus rattus]
 264.0 [0..154] [480..2]
gi|109097199 - gi|109097199|ref|XP_001113345.1| PREDICTED: cyclin-dependent kinase 2 isoform 6 [Macaca mulatta]
 263.0 [0..154] [480..2]
gi|30583821, gi|... - gi|61372546|gb|AAX43864.1| cyclin-dependent kinase 2 [synthetic construct], gi|60830574|gb|AAX36935....
 263.0 [0..154] [480..2]
tr|M3WJU6|M3WJU6... - Cyclin dependent kinase 2 OS=Felis catus GN=CDK2 PE=3 SV=1
gi|73968309 - gi|73968309|ref|XP_856049.1| PREDICTED: similar to cyclin-dependent kinase 2 isoform 6 [Canis famili...
 263.0 [0..154] [480..2]

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Predicted Domain #1
Region A:
Residues: [1-127] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESRSKVKTY GKNRRYINKD IEIWASLDER PCALKPRNIE NFNNQERSDL EHIHSKPKKD  60
   61 SLLSWNILLK KGSYKENELL AKRNQNLVPT VIIPASPRDN ASKSVVSKKE VVNLSSSVAL 120
  121 SGKPANN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [128-488] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKLDPLHRLL QIVAQEDALP FSQFVKSQTF EIQKIGEASY SEVYQASNAD DVPVVWKVIP  60
   61 FGEDGQAQYA DVLNEVQISQ WIKVDGFANL HQVVVVKGTY PSLLLEEWDR YLMQNGSEND 120
  121 RPDSYSSTQL YCVLCLDHSG TDLEHFELRS WRECWSVFYE TLKILSLVET RYEFEHRDLH 180
  181 WGNILIRKAD RSEEEVSFLL NEISLDDIES VDFPGSQDKA DDFDNILQVT LIDFTLARAS 240
  241 YSQGIISYNE FNDPDLFNGV DDYQFDIYRL MSRVTKGRWA QFFPITNVLW LHYLIHQLLH 300
  301 KKNLSSPLTE TETLMRSRLK QIFRLIDPVK TMQFQQAEDS IRSKSTVTSA TSLLNWVRQK 360
  361 Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.0
Match: 1bmkA
Description: MAP kinase p38
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.38496328649031 bayes_pls_golite062009
receptor signaling protein activity 1.27291233344322 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.684204466593894 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.499492353295369 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
MAP kinase activity 0.26024936404169 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.196560862858137 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle