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View Structure Prediction Details

Protein: rga6
Organism: Schizosaccharomyces pombe
Length: 733 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rga6.

Description E-value Query
Range
Subject
Range
LRG1 - Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that contr...
258.0 [0..3] [601..452]
gi|114644843, gi... - gi|114644863|ref|XP_001156519.1| PREDICTED: hypothetical protein isoform 8 [Pan troglodytes], gi|114...
239.0 [0..58] [604..112]
HGNC:9804|MIM:60... - GTPase activating protein 1
RACGAP1 - Rac GTPase activating protein 1
gi|117646526, gi... - gi|168275488|dbj|BAG10464.1| Rac GTPase-activating protein 1 [synthetic construct], gi|157928860|gb|...
238.0 [0..58] [604..112]
gi|109096581, gi... - gi|109096581|ref|XP_001110640.1| PREDICTED: similar to Rac GTPase activating protein 1 isoform 1 [Ma...
237.0 [0..58] [604..112]
gi|73996453 - gi|73996453|ref|XP_543675.2| PREDICTED: similar to Rac GTPase activating protein 1 isoform 1 [Canis ...
233.0 [0..88] [604..138]

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Predicted Domain #1
Region A:
Residues: [1-182]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLNPSTLNN GTLGDLKEHK DVVLSSNAQT DEKRFEEPSL EVGGSLAKVE NGLSTSISSS  60
   61 ASNLEGQQAP FFTKQNSCLS RFRELAQTYN IHEINLEEYV SQIKEVKQSL YSDDSVFNES 120
  121 KSSSPPDAHT DKYFTPCGSP TKLIHSTLLE ERDTPSSLEH VSFYLQESAV SEVRFDKPSN 180
  181 NG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [183-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLGRSSLNLS SLSHELQTSQ DSPSLSATNQ LSSSDTLEPL QYPPSSFGSQ RQFNASQDSP  60
   61 KRSPSKGSWS SILRRPSLTY SPKRQSTGLH RRSLTNYFKF PHRNAHQHNA IAHNPSVFGK 120
  121 PIGDLTSDPT NLCKFTFPTP ECAPPSLLLP HIFAQCVHFL SLNALHVPGI FRISGSGPVI 180
  181 KAITEYFYSP PHFWLDETSE IFKRIGFPSY IDIAAVLKRY IMLLPGGLFT HKDILNLLVP 240
  241 LYVDSSRVKV PIDIRNEMAA LCFSQIDSYV RFSILCSLLA LLHQIATRTQ ELENGMENTK 300
  301 DSTLMKPEAL GIIFGPLLLG NSSTDLSKSC PSGNVNDLMR FETEKARVEA KIVEGLIIHW 360
  361 PEVLLKINSL DIPNC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.0
Match: 1xa6A
Description: Crystal Structure of the Human Beta2-Chimaerin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Rho GTPase activator activity 4.25739379139603 bayes_pls_golite062009
Rac GTPase activator activity 4.16341873243208 bayes_pls_golite062009
GTPase regulator activity 2.41361462392252 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 2.38885756088 bayes_pls_golite062009
binding 1.8899231872471 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 1.79187892586384 bayes_pls_golite062009
enzyme regulator activity 1.70400915650397 bayes_pls_golite062009
small GTPase regulator activity 1.65078918289568 bayes_pls_golite062009
protein binding 1.03543141739589 bayes_pls_golite062009
Ras GTPase activator activity 0.769564483290942 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.724386087400895 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 0.697083262102355 bayes_pls_golite062009
GTPase activator activity 0.423342320468982 bayes_pls_golite062009
enzyme activator activity 0.0257933085345788 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [558-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSDVGLTDQV AIFTPAVPKE DSPEQIPENV NASEESYPNV KHISKLPLIN DSSDNESGNQ  60
   61 ENDDAVANES TKVVVDNQQP QPKISTVSDT AVPSMSFANN ISSRSVISAA TDSKPSTRTS 120
  121 PPFVNNTKPI VAKSPVTVTA SSETNKKSQK INKKASPRVS LWTKLFGKFR SNKKKS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle