YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC1604.09c
Organism:	Schizosaccharomyces pombe
Length:	260 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC1604.09c.

Description	E-value	Query Range	Subject Range
DPO3_CALS4 - DNA polymerase III PolC-type OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242... DPO3_THETN - DNA polymerase III polC-type OS=Thermoanaerobacter tengcongensis GN=polC PE=3 SV=1	215.0	[0..9]	[259..309]
DPO3_BACSU - DNA polymerase III polC-type OS=Bacillus subtilis GN=polC PE=1 SV=2 gi\|221318783 - gi\|221318783\|ref\|ZP_03600077.1\| DNA polymerase III PolC [Bacillus subtilis subsp. subtilis str. JH64... gi\|221313860 - gi\|221313860\|ref\|ZP_03595665.1\| DNA polymerase III PolC [Bacillus subtilis subsp. subtilis str. NCIB... gi\|221323055 - gi\|221323055\|ref\|ZP_03604349.1\| DNA polymerase III PolC [Bacillus subtilis subsp. subtilis str. SMY] DPO3_BACSU - DNA polymerase III PolC-type OS=Bacillus subtilis (strain 168) GN=polC PE=1 SV=2	209.0	[0..11]	[260..343]
gi\|89098599, gi\|... - gi\|89098599\|ref\|ZP_01171481.1\| DNA polymerase III subunit alpha [Bacillus sp. NRRL B-14911], gi\|8908...	209.0	[0..9]	[255..345]
gi\|56419793, gi\|... - gi\|56419793\|ref\|YP_147111.1\| DNA polymerase III PolC [Geobacillus kaustophilus HTA426], gi\|56379635\|...	209.0	[0..9]	[254..349]
gi\|220931624, gi... - gi\|89209761\|ref\|ZP_01188156.1\| DNA polymerase III, epsilon subunit:DNA polymerase III, alpha subunit...	207.0	[0..9]	[257..305]
gi\|152976184, gi... - gi\|89203212\|ref\|ZP_01181903.1\| DNA polymerase III, epsilon subunit:DNA polymerase III, alpha subunit...	207.0	[0..9]	[255..338]
gi\|125973511, gi... - gi\|67917180\|ref\|ZP_00510847.1\| DNA polymerase III, epsilon subunit:DNA polymerase III, alpha subunit...	205.0	[0..9]	[257..350]
DPO3_STRPN - DNA polymerase III polC-type OS=Streptococcus pneumoniae GN=polC PE=3 SV=1 DPO3_STRPN - DNA polymerase III PolC-type OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN...	205.0	[0..9]	[259..345]
gi\|143342 - gi\|143342\|gb\|AAA22666.1\| polymerase III	204.0	[0..11]	[260..343]
gi\|52348140, gi\|... - gi\|52785638\|ref\|YP_091467.1\| DNA polymerase III PolC [Bacillus licheniformis ATCC 14580], gi\|5234814...	204.0	[0..11]	[260..344]

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Predicted Domain #1

Region A:
Residues: [1-89]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSNWEKLK KKLDSAKSGR VEKKHSNEKK YLKSVKGKNN ENENSYIVDK KRMNELKKFA  60
   61 KENDIPESQV LDAYGVDASK LTRKTNLET

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [90-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGKYIAMDCE MVGVADDMSV LARVSIVNYH GHVVYDTYVR PKEKVTDWRT WVSGVKSFHM  60
   61 RDAPSFEKVQ AEVAKILDNR VLVGHAVHND LKVLLLSHPR RMIRDTSRFS GYRKLAKGRT 120
  121 PGLKKLAEVI LGRDIQSGQH SSVQDAQATM ELYKKVKKEM DEVAFKGLSK S

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.30103
Match:	1wljA
Description:	human ISG20
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonuclease activity	5.30591758406946	bayes_pls_golite062009
exoribonuclease activity	3.71639182685131	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	3.59362615133405	bayes_pls_golite062009
exonuclease activity	3.13676176369406	bayes_pls_golite062009
nuclease activity	3.11657409772275	bayes_pls_golite062009
ribonuclease H activity	2.91966688044755	bayes_pls_golite062009
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	2.75003136922541	bayes_pls_golite062009
endonuclease activity	2.63074055051349	bayes_pls_golite062009
endoribonuclease activity	2.59247838057313	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.57498413015114	bayes_pls_golite062009
hydrolase activity	2.41899414621161	bayes_pls_golite062009
3'-5'-exoribonuclease activity	2.12039058720352	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2.04408785855894	bayes_pls_golite062009
	2.02108278477989	bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters	1.74431545836806	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.59628511603826	bayes_pls_golite062009
3'-5' exonuclease activity	1.44123900197846	bayes_pls_golite062009
catalytic activity	1.25233849524628	bayes_pls_golite062009
protein binding	1.16870279238939	bayes_pls_golite062009
deoxyribonuclease activity	1.1219517187744	bayes_pls_golite062009
transcription regulator activity	1.10433412699603	bayes_pls_golite062009
nucleic acid binding	1.04079362397031	bayes_pls_golite062009
DNA binding	0.860359347662869	bayes_pls_golite062009
binding	0.762139256580538	bayes_pls_golite062009
RNA binding	0.750194803368593	bayes_pls_golite062009
DNA polymerase activity	0.717600245625866	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.568273228950698	bayes_pls_golite062009
transcription factor activity	0.332903382446869	bayes_pls_golite062009
exodeoxyribonuclease activity	0.278838342302102	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.261428436029202	bayes_pls_golite062009
structure-specific DNA binding	0.0701825322473915	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.00214157813118243	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: