YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|46396277, gi\|...
Organism:	Schizosaccharomyces pombe
Length:	572 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|46396277, gi|....

Description	E-value	Query Range	Subject Range
mus81 - Holliday junction resolvase subunit Mus81 MUS81_SCHPO - Crossover junction endonuclease mus81 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mus8...	527.0	[0..1]	[572..37]
MUS81_NEUCR - Crossover junction endonuclease mus-81 OS=Neurospora crassa GN=mus-81 PE=3 SV=1 MUS81_NEUCR - Crossover junction endonuclease mus-81 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 70...	457.0	[0..1]	[568..40]
MUS81_GIBZE - Crossover junction endonuclease MUS81 OS=Gibberella zeae GN=MUS81 PE=3 SV=1 MUS81_GIBZE - Crossover junction endonuclease MUS81 OS=Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / ...	438.0	[0..1]	[568..40]
MUS81_ASHGO - Crossover junction endonuclease MUS81 OS=Ashbya gossypii GN=MUS81 PE=3 SV=1 MUS81_ASHGO - Crossover junction endonuclease MUS81 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923...	429.0	[0..1]	[568..42]
gi\|145021466, gi... - gi\|39945206\|ref\|XP_362140.1\| hypothetical protein MGG_04585 [Magnaporthe grisea 70-15], gb\|EAA50826....	407.0	[0..1]	[568..41]
MUS81_DANRE - Crossover junction endonuclease MUS81 OS=Danio rerio GN=mus81 PE=1 SV=1	406.0	[0..1]	[570..51]
gi\|190404676 - gi\|190404676\|gb\|EDV07943.1\| class II crossover junction endonuclease MUS81 [Saccharomyces cerevisiae... MUS81_YEAST - Crossover junction endonuclease MUS81 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MU... MUS81 - Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in D...	404.0	[0..1]	[568..40]
MUS81_EMENI - Crossover junction endonuclease mus81 OS=Emericella nidulans GN=mus81 PE=3 SV=1 MUS81_EMENI - Crossover junction endonuclease mus81 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112....	398.0	[0..1]	[568..119]
MUS81_RAT - Crossover junction endonuclease MUS81 OS=Rattus norvegicus GN=Mus81 PE=2 SV=1	393.0	[0..1]	[572..50]
gi\|88185325, gi\|... - gi\|88185325\|gb\|EAQ92793.1\| hypothetical protein CHGG_01028 [Chaetomium globosum CBS 148.51], gi\|1161...	390.0	[0..1]	[568..40]

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Predicted Domain #1

Region A:
Residues: [1-225]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSCPITFHR PSQALALKGI GPTICAKLEK KWNAYCLENN IPISTHNEQN DSHVNANKSS  60
   61 SETSSEKPRS VKKPTTRKRK VYVPSYRSGA YSILCALYML NKHEFATKPQ IVTMAQPYCD 120
  121 SSFGSATDRN MRYTAWSAMK TLITKNLVYQ TGHPSKYCLT DDGEEVCIRL AKVDDSFQRK 180
  181 HTVSNFSVSK SDDHDSSLCQ PPNFVTSINK AGSSSDHGGE LHVTY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.0
Match:	1wp9A
Description:	Crystal structure of Pyrococcus furiosus Hef helicase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [226-282]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CPVDHNEVSD GVETDIDVDQ VDSLTGIHDH HIINNEQLID LTEQEKKQPN ESNLSNL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [283-572]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KIETVLFSNC TVFLLIDTRE IRSPLDRNLI IDKLTNDFGV NCQVRSLELG DALWVARDME  60
   61 SGQEVVLDFV VERKRYDDLV ASIKDGRFHE QKARLKKSGI RSVTYILEES SYDESFTESI 120
  121 RTAVSNTQVD QLFHVRHTRS LEHSVSLLAE MTKQINLFYE KRKTLAVIPD LSIEAKTYES 180
  181 LREQLLKIDP STPYHISYHA FSSVLSKSST LTVGDIFIRM LMTIKGISAS KAIEIQKKYP 240
  241 TFMHLFEAYE KSSSSQERNL LLNKTCQGYG FQTIGPALSA KVASVFFPES

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.0
Match:	2bgwA
Description:	XPF from Aeropyrum pernix, complex with DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
four-way junction helicase activity	10.562254984301	bayes_pls_golite062009
DNA helicase activity	7.81641089090703	bayes_pls_golite062009
endodeoxyribonuclease activity	3.88121538069074	bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity	3.87045877570028	bayes_pls_golite062009
deoxyribonuclease activity	3.62965779224499	bayes_pls_golite062009
excinuclease ABC activity	3.48615352002265	bayes_pls_golite062009
DNA binding	2.97855002479178	bayes_pls_golite062009
structure-specific DNA binding	2.83758378400856	bayes_pls_golite062009
nucleic acid binding	2.79236389919005	bayes_pls_golite062009
single-stranded DNA binding	2.79104877030658	bayes_pls_golite062009
damaged DNA binding	2.3008149920351	bayes_pls_golite062009
helicase activity	2.29491252701513	bayes_pls_golite062009
binding	2.17324322139334	bayes_pls_golite062009
nuclease activity	1.92659045080864	bayes_pls_golite062009
endonuclease activity	1.7109181764667	bayes_pls_golite062009
DNA strand annealing activity	1.5117854648336	bayes_pls_golite062009
pyrophosphatase activity	1.02983374615445	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.02325715570644	bayes_pls_golite062009
catalytic activity	0.816447099398022	bayes_pls_golite062009
double-stranded DNA binding	0.73359455482295	bayes_pls_golite062009
protein binding	0.71091195096997	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: