YRC Public Data Repository - Protein Structure Prediction

Protein:	fft1
Organism:	Schizosaccharomyces pombe
Length:	944 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for fft1.

Description	E-value	Query Range	Subject Range
gi\|39930329, gi\|... - ref\|NP_035547.1\| SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfami...	472.0	[0..2]	[931..347]
gi\|996018, gi\|45... - gi\|996018\|emb\|CAA62831.1\| BRG1 protein [Gallus gallus], gi\|45384232\|ref\|NP_990390.1\| BRG1 protein [G...	460.0	[0..2]	[942..345]
gi\|73986636 - gi\|73986636\|ref\|XP_853739.1\| PREDICTED: similar to SWI/SNF-related matrix-associated actin-dependent...	457.0	[0..2]	[942..347]
gi\|114675380 - gi\|114675380\|ref\|XP_512384.2\| PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator...	456.0	[0..2]	[942..347]
gi\|119604570, gi... - gi\|192807323\|ref\|NP_001122321.1\| SWI/SNF-related matrix-associated actin-dependent regulator of chro...	455.0	[0..2]	[942..347]
gi\|62653326, gi\|... - gi\|62653326\|ref\|XP_343359.2\| PREDICTED: similar to SWI/SNF-related matrix-associated actin-dependent...	452.0	[0..2]	[942..347]

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Predicted Domain #1

Region A:
Residues: [1-208]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRKDNKELI CIPSSSPPST PIREENYYLL TSSPIECSPI QQLDLSGSFK NYSTTSSRAN  60
   61 GKKFGQLAMQ SRIFFDTTDH KKYVESSYAA YDPHDQPPER DVSLKESSNK INPSNFFDSE 120
  121 QITKINAVKK RFPALDSEMI IATLEKFNWR ENITIHKLTF QKLLGRGNST INKSAQKLNN 180
  181 QPIEKSSVDK ENAKRKRYVE EGTKQGQK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [209-292]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKPLRVIELS DEETNEDDLL GQSPTACTTD ANIDNSIPEN SDKIEEVSIE SSGPSEVEDE  60
   61 MSEYDVRVLN FLNESTLQEI VEVS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.483	a.74.1	Cyclin-like
View	Download	0.319	a.74.1	Cyclin-like
View	Download	0.314	a.74.1	Cyclin-like
View	Download	0.286	a.74.1	Cyclin-like
View	Download	0.267	a.74.1	Cyclin-like

Predicted Domain #3

Region A:
Residues: [293-401]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GCESKVVEYF ISKRPFPSLE KAEALCQRNA HAATGKRKKS DGRNVGRKLV NSTYEVLQGF  60
   61 DAVDSLIAKC ERYGAMISNT MRSWHNLFDD KKMEQFLNTS TGSISYEYN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.0
Match:	1rifA
Description:	Crystal structure of the UvsW helicase from Bacteriophage T4
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [402-944]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SQQPSSIASG ITLKSYQIVG LNWLCLMYKA KLSGILADEM GLGKTCQVIS FLASLKEKGI  60
   61 QNRHLVVVPS STLGNWLREF EKFCPSLRVE SYSGTQSERI NKRYYLMDTD FDVLVTTYQL 120
  121 ASGSRDDRSF LRKQRFDISI FDEGHYLKNR MSERYKHLMN IPANFRLLIT GTPLQNNLKE 180
  181 LISLLAFMLP KVFDNNMQGL DIIYKIKTTS DGDIERAYLS QERISRAKTI MNPFILRRRK 240
  241 ENVLSDLPPK IQHVEYCHME ETQLSLYLSV LELKNLVNAN RENILMQLRK AALHQLLFRS 300
  301 QYNLETLSLM SKRILREDAY LDANPQYIFE DMEVMSDFEL HKLADQYRHL HPFALKGKPW 360
  361 MDSAKVKKLC SLLKKSRPNE RILIFSQFTQ VLDILEYVLN TLDLEFLRLD GSTPVETRQQ 420
  421 LIDDFHTNEN YKVFLLSTKS GGFGINLTCA NIVILFDCSF NPFDDMQAED RAHRVGQTRP 480
  481 VHVYRLITKN TIEENIRRLA NTKLTLESSL TTDSEKIQKE ISGELMKSLQ MDGRVDTMDG 540
  541 SVV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	83.39794
Match:	1z3iX
Description:	Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA-dependent ATPase activity	2.58390156971125	bayes_pls_golite062009
binding	2.4974940028864	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.94405657559372	bayes_pls_golite062009
pyrophosphatase activity	1.87046999221652	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.85030653553169	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.84811666933472	bayes_pls_golite062009
DNA helicase activity	1.72320119360938	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.52935820732225	bayes_pls_golite062009
helicase activity	1.33212695797068	bayes_pls_golite062009
motor activity	1.14667913749579	bayes_pls_golite062009
histone acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
hydrolase activity	0.985656549643169	bayes_pls_golite062009
purine NTP-dependent helicase activity	0.89390151223569	bayes_pls_golite062009
ATP-dependent helicase activity	0.89390151223569	bayes_pls_golite062009
protein-DNA loading ATPase activity	0.707571682109441	bayes_pls_golite062009
microtubule motor activity	0.60036517876321	bayes_pls_golite062009
structure-specific DNA binding	0.579644950922817	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
catalytic activity	0.458437698837681	bayes_pls_golite062009
protein binding	0.378225828131122	bayes_pls_golite062009
purine nucleotide binding	0.370109410491501	bayes_pls_golite062009
nucleotide binding	0.367488441096941	bayes_pls_golite062009
purine ribonucleotide binding	0.348507955395744	bayes_pls_golite062009
ribonucleotide binding	0.348454114797054	bayes_pls_golite062009
DNA clamp loader activity	0.229994987891881	bayes_pls_golite062009
double-stranded DNA binding	0.2192434828134	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: