YRC Public Data Repository - Protein Structure Prediction

Protein:	SPBC725.04
Organism:	Schizosaccharomyces pombe
Length:	568 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC725.04.

Description	E-value	Query Range	Subject Range
gi\|146399240, gi... - gi\|88936939\|ref\|ZP_01142531.1\| Acetolactate synthase, large subunit, biosynthetic type [Geobacter ur...	528.0	[0..1]	[550..1]
gi\|222054607, gi... - gi\|222054607\|ref\|YP_002536969.1\| acetolactate synthase, large subunit, biosynthetic type [Geobacter ...	524.0	[0..1]	[550..1]
gi\|77919506, gi\|... - gi\|77919506\|ref\|YP_357321.1\| acetolactate synthase, large subunit, biosynthetic type [Pelobacter car...	524.0	[0..1]	[551..1]
gi\|20092588, gi\|... - gi\|20092588\|ref\|NP_618663.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina acetivorans C...	524.0	[0..2]	[551..8]
gi\|72394929, gi\|... - gi\|73667767\|ref\|YP_303782.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina barkeri str. ...	524.0	[0..2]	[551..8]
gi\|21226772, gi\|... - gi\|21226772\|ref\|NP_632694.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina mazei Go1], g...	523.0	[0..2]	[551..8]
gi\|78193729, gi\|... - gi\|78222474\|ref\|YP_384221.1\| acetolactate synthase, large subunit [Geobacter metallireducens GS-15],...	521.0	[0..1]	[550..1]
gi\|20093969, gi\|... - gi\|20093969\|ref\|NP_613816.1\| acetolactate synthase catalytic subunit [Methanopyrus kandleri AV19], g...	521.0	[0..4]	[559..6]
gi\|7436698 - pir\|\|C70341 acetolactate synthase (EC 4.1.3.18) large chain - Aquifex aeolicus gi\|15605942, gi\|... - gi\|2983101\|gb\|AAC06706.1\| acetolactate synthase large subunit [Aquifex aeolicus VF5], gi\|15605942\|re...	521.0	[0..4]	[551..5]
gi\|39997009, gi\|... - gi\|39997009\|ref\|NP_952960.1\| acetolactate synthase, large subunit, biosynthetic type [Geobacter sulf...	520.0	[0..1]	[550..1]

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Predicted Domain #1

Region A:
Residues: [1-568]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSISFSELVA KTLLDLEVKV VFGIVGIPVI EICEAIQASG IRFVGFRNEQ SAAYAATAYG  60
   61 YLTQRPGVCV VVGGPGVVHA MAGVFNSKTN RWPLLLLAGS SETFQQNCGA FQELDQVSYL 120
  121 SPHTKLAVRP PSPKMVVDSI RRAYRVSMTG TPGTCYVDLP ANYIESTVDD FPKDPLPPIP 180
  181 SSPKCAPDPT QLQKAAYYLK NAKAPLLVVG KGAAYACAEK QLLEFVEHTG IPFLPSPMGK 240
  241 GLLPESHPLN VSSARSAALR NADVVLLAGA RLNWIFQYGL PPKWSPNAKF IQIDTNAETL 300
  301 GNNAADLDLA IWADVGLTID CLFKLVQTWK YSVGISTPYL RTLNETRSKN EKKALESRKS 360
  361 SIPLQMNYAL YVVNEELQSL SLKSKRNITW VSEGANTMDR GRQLLEVTHP RGRLDAGTMS 420
  421 TMGVGMGYAI ASAFAHSSDK IVVVEGDSAF GFSAMELETA IRNQLDLLVI VINNNGVYHG 480
  481 LDTDAYETLR DNHQLPTTAL GTSIRYDQIC EACGGKGFFV KNEEDLRSSL RKAWQTSSVS 540
  541 LINVMVDPEA ARKLTFAWMS STKVKPKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.69897
Match:	2c31A
Description:	CRYSTAL STRUCTURE OF OXALYL-COA DECARBOXYLASE IN COMPLEX WITH THE COFACTOR DERIVATIVE THIAMIN-2-THIAZOLONE DIPHOSPHATE AND ADENOSINE DIPHOSPHATE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	12.903449876837	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	12.3239025230705	bayes_pls_golite062009
pyruvate dehydrogenase activity	5.28857071459273	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.21233670052586	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	5.08663245333808	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.15444163802756	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.98546381612935	bayes_pls_golite062009
thiamin pyrophosphate binding	1.87247313698582	bayes_pls_golite062009
oxidoreductase activity	1.85833680148029	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.82969293063325	bayes_pls_golite062009
transketolase activity	1.70348931648612	bayes_pls_golite062009
deoxyhypusine synthase activity	1.46517585302326	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.0611726850452	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.982646671777	bayes_pls_golite062009
protein deacetylase activity	0.882978552120903	bayes_pls_golite062009
histone deacetylase activity	0.881399086357632	bayes_pls_golite062009
cation transmembrane transporter activity	0.78591260444574	bayes_pls_golite062009
hydrolase activity	0.536729211484905	bayes_pls_golite062009
ion transmembrane transporter activity	0.51426028502998	bayes_pls_golite062009
transferase activity	0.413024577830522	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	0.38348854354211	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	0.38348854354211	bayes_pls_golite062009
deacetylase activity	0.382228826641711	bayes_pls_golite062009
binding	0.313299160093284	bayes_pls_golite062009
transcription regulator activity	0.217707914161459	bayes_pls_golite062009
nucleic acid binding	0.0424046736878951	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: