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View Structure Prediction Details

Protein: mst2
Organism: Schizosaccharomyces pombe
Length: 407 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mst2.

Description E-value Query
Range
Subject
Range
gi|46128207, gi|... - gi|46128207|ref|XP_388657.1| hypothetical protein FG08481.1 [Gibberella zeae PH-1], gi|42548455|gb|E...
571.0 [0..2] [391..434]
gi|38104262, gi|... - gi|39945266|ref|XP_362170.1| hypothetical protein MG04615.4 [Magnaporthe grisea 70-15], gb|EAA50856....
562.0 [0..4] [396..444]
gi|39979199 - gi|39979199|emb|CAE85570.1| related to histone acetyltransferase [Neurospora crassa]
557.0 [0..13] [391..499]
gi|32407080, gi|... - gi|32407080|ref|XP_324139.1| hypothetical protein [Neurospora crassa], gi|28921714|gb|EAA30995.1| hy...
gi|85096272 - gi|85096272|ref|XP_960231.1| hypothetical protein [Neurospora crassa OR74A]
557.0 [0..13] [391..471]
gi|40743543, gi|... - gi|67538940|ref|XP_663244.1| hypothetical protein AN5640.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
545.0 [0..12] [391..392]
gi|116202125, gi... - gi|88177465|gb|EAQ84933.1| hypothetical protein CHGG_08947 [Chaetomium globosum CBS 148.51], gi|1162...
542.0 [0..18] [396..428]
gi|83768076 - gi|83768076|dbj|BAE58215.1| unnamed protein product [Aspergillus oryzae]
gi|169771495 - gi|169771495|ref|XP_001820217.1| hypothetical protein [Aspergillus oryzae RIB40]
534.0 [0..2] [391..425]
gi|66849371, gi|... - gi|70993780|ref|XP_751737.1| histone acetyltransferase [Aspergillus fumigatus Af293], gi|66849371|gb...
532.0 [0..2] [386..391]
gi|114194085, gi... - gi|115391313|ref|XP_001213161.1| protein mst2 [Aspergillus terreus NIH2624], gi|114194085|gb|EAU3578...
531.0 [0..2] [391..380]
gi|73958300 - gi|73958300|ref|XP_536904.2| PREDICTED: similar to Probable histone acetyltransferase MYST1 (MYST pr...
521.0 [0..27] [378..93]

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Predicted Domain #1
Region A:
Residues: [1-82]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPATILKSTA SSKTLLIIKF DTNSSRYPFY KKHLLELNSE STFLGLLTKG QADTSITRLN  60
   61 QDDVRLFEKA KTVADRTKDV AY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.154902
Match: 1wgsA
Description: Solution Structure of the Tudor Domain from Mouse Hypothetical Protein Homologous to Histone Acetyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
methylated histone residue binding 3.42338304360938 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
protein binding 2.66728689880621 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
transcription activator activity 1.46529895769882 bayes_pls_golite062009
sequence-specific DNA binding 1.10020047862576 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [83-407]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFSDPILSTQ LRTPPPQPTS IRYLYFGTYR IKPWYTSPYP EEYSCAKNLY ICESCLKYMN  60
   61 SDHVLQRHKM KCSWSYPPGD EIYRDKNISI FEVDGQRQPI YCQNLCLLAK MFLHSKMLYY 120
  121 DVEPFLFYVL TEFDGQECKV IGYFSKEKRS ASDYNVSCIL TLPIYQRRGY GVFLIDFSYL 180
  181 LTQVEGKLGS PEKPLSDLGL VTYRSYWKMR VAKALLEITT PISINAIAKS TSMVCDDVIS 240
  241 TLESLSVFKY DPLKKKYVLQ LKRDELENVY KAWNIKHPQR VNPKLLRWTP YLGEEQISNL 300
  301 LLKENILIPL PQKRLLDNSH HLDSV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 131.0
Match: 2givA
Description: No description for 2givA was found.

Predicted functions:

Term Confidence Notes
N-acetyltransferase activity 10.330867741687 bayes_pls_golite062009
histone acetyltransferase activity 10.2385402730839 bayes_pls_golite062009
lysine N-acetyltransferase activity 10.2385402730839 bayes_pls_golite062009
N-acyltransferase activity 10.2097972775096 bayes_pls_golite062009
acetyltransferase activity 9.5414870492393 bayes_pls_golite062009
acyltransferase activity 8.84144467104026 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 8.80032457938662 bayes_pls_golite062009
transferase activity, transferring acyl groups 8.58458341779614 bayes_pls_golite062009
7.30820970670781 bayes_pls_golite062009
3.86052919290021 bayes_pls_golite062009
transferase activity 3.5778020729894 bayes_pls_golite062009
transcription regulator activity 2.24760844790231 bayes_pls_golite062009
transcription activator activity 2.22111981353244 bayes_pls_golite062009
nucleic acid binding 2.13750665291344 bayes_pls_golite062009
catalytic activity 1.97933499002461 bayes_pls_golite062009
myristoyltransferase activity 1.56556272138444 bayes_pls_golite062009
glycylpeptide N-tetradecanoyltransferase activity 1.56556272138444 bayes_pls_golite062009
transcription repressor activity 1.31507488567214 bayes_pls_golite062009
binding 1.22537494136129 bayes_pls_golite062009
transcription coactivator activity 1.2180007740195 bayes_pls_golite062009
transcription factor binding 1.13174003342838 bayes_pls_golite062009
protein binding 1.12627968510377 bayes_pls_golite062009
H3 histone acetyltransferase activity 0.710926740598251 bayes_pls_golite062009
histone binding 0.582104626133107 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.483579890542134 bayes_pls_golite062009
transcription cofactor activity 0.31196049232138 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle