YRC Public Data Repository - Protein Structure Prediction

Protein:	kap111
Organism:	Schizosaccharomyces pombe
Length:	990 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for kap111.

Description	E-value	Query Range	Subject Range
gi\|194220699 - gi\|194220699\|ref\|XP_001917538.1\| PREDICTED: similar to Exportin 1, CRM1 homolog (yeast) [Equus cabal... gi\|119903678 - gi\|119903678\|ref\|XP_587722.3\| PREDICTED: similar to Exportin 1, CRM1 homolog (yeast) [Bos taurus] gi\|73969724 - gi\|73969724\|ref\|XP_531839.2\| PREDICTED: similar to exportin 1, CRM1 homolog isoform 1 [Canis familia...	437.0	[0..5]	[928..24]
gi\|115402009, gi... - gi\|115402009\|ref\|XP_001217081.1\| exportin-1 [Aspergillus terreus NIH2624], gi\|114188927\|gb\|EAU30627....	435.0	[0..4]	[927..3]
gi\|51491264 - gi\|51491264\|emb\|CAH18695.1\| hypothetical protein [Homo sapiens]	435.0	[0..5]	[928..24]
XPO1_MOUSE - Exportin-1 OS=Mus musculus GN=Xpo1 PE=1 SV=1	435.0	[0..5]	[928..24]
XPO1_RAT - Exportin-1 OS=Rattus norvegicus GN=Xpo1 PE=1 SV=1	434.0	[0..5]	[928..24]
gi\|169768160 - gi\|169768160\|ref\|XP_001818551.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83766406 - gi\|83766406\|dbj\|BAE56549.1\| unnamed protein product [Aspergillus oryzae]	434.0	[0..5]	[931..4]
gi\|114577570, gi... - gi\|114577572\|ref\|XP_001161265.1\| PREDICTED: exportin 1 isoform 3 [Pan troglodytes], gi\|114577570\|ref...	434.0	[0..5]	[928..24]
gi\|147903733, gi... - gi\|47125110\|gb\|AAH70550.1\| Xpo1 protein [Xenopus laevis], gi\|147903733\|ref\|NP_001083734.1\| CRM1/XPO1...	432.0	[0..5]	[928..24]

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Predicted Domain #1

Region A:
Residues: [1-901]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGNEIAHAK KLVYDLYSGS LSPSAIAATE KELQKAQRSQ QGWNIGLFML QSKDVYEQFF  60
   61 GALTLQMKIN TQLETLSDKD LVQLFVQLLQ KLLWDDGLPA LVERKVICTL ASLTIKYELE 120
  121 KKEEASLKVI YCLFCNKLEF FNADMNAASV LNNLFPPASS RNAQLTASYI NELLLELSFS 180
  181 IYTKENEDAL FNNVFRPCSN IIVSVLVFIF TNYSLDLSKE KNVAALEEAL NCMIAISSYL 240
  241 AKASVSVQSV LPAFTECMDL TVNCIALDEV SEKAMNCLAD LLANYSNFIT QPTIERLWTI 300
  301 LTGPWGETHL QQELEDPDSG EENDYSFLNI VIGFAEAMLP QIIDHIQEEK SIRLLYILAS 360
  361 LLSFPGYAIV EEKVSWRTLE FWTTLIEDFS MSKAATDPSK DEIFKQIAFS VVEKAWWKML 420
  421 LPSPEQWNSW PSSSRDSFNS YRRDLGDLLE SSYSIFGERL YAMYITTIEN FFSDGTGSPQ 480
  481 SLEVSFYCLC CILEYDTNDS DTLDAWLTRL FETSFAIKAS AFQNPQLLKT CSQLLSSCSC 540
  541 FLQNHPQYLN ISLPVLFDAL HISETSIQMT VSRSIHTLCT TCASHLLTEI DGFMAVVEEL 600
  601 TPKLVYVPSV LEKIYSSVGY VTQRIEDIEL RISYLMRLLN CILAQLQPSL YPNLEIFENV 660
  661 LKSCLQSVAG VALSQSPIGE SPIIDVEQST QETTFWQQSC IAEFQAKLIS FLTHSESMAL 720
  721 QYSDVVGLIC KIMIAGLNEV EPSPFSLPIV TTIQYFCDRF TEFPAAVLLT LGSAILTCPY 780
  781 GQTDIIDKVL IDMCSSIQNS VVIINEESFM NNIDITVELY HFFSIILQKH PSFLETMYPD 840
  841 FTQLILNRAI NLLGKPERLL ESAAGQFIIS FITSEKSDLL NTHTDFVNAI RSPLIAKILL 900
  901 G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.39794
Match:	1qbkB
Description:	Karyopherin beta2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	3.92743254165888	bayes_pls_golite062009
binding	2.61658111885029	bayes_pls_golite062009
transporter activity	2.48700774379895	bayes_pls_golite062009
substrate-specific transporter activity	2.26725422172281	bayes_pls_golite062009
protein binding	2.13529412360404	bayes_pls_golite062009
protein transmembrane transporter activity	2.06444045538785	bayes_pls_golite062009
nuclear export signal receptor activity	1.29390474721722	bayes_pls_golite062009
transmembrane transporter activity	1.28481004323799	bayes_pls_golite062009
nuclear localization sequence binding	1.27627067567874	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.09652988954158	bayes_pls_golite062009
RNA binding	0.97764812194782	bayes_pls_golite062009
active transmembrane transporter activity	0.252495966234234	bayes_pls_golite062009
ion transmembrane transporter activity	0.248585912061178	bayes_pls_golite062009
primary active transmembrane transporter activity	0.226380819487924	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.217517113570989	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.178770060806735	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.175241020572885	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.174922130116569	bayes_pls_golite062009
nucleic acid binding	0.169755106399802	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.100181463251306	bayes_pls_golite062009
pyrophosphatase activity	0.0635404099346928	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0548082069333885	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.052195223119721	bayes_pls_golite062009
cation transmembrane transporter activity	0.0405268469927988	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [902-990]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGGNASRSSL PLLSDILGKL KAQNFSATRA CLTQSLEEEG FPSRNVSNEI KRRFLTDLLK  60
   61 ARIKDKVKQF WILCKGLEST PYGNSSWTF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.334	a.21.1	HMG-box
View	Download	0.426	a.144.1	PABC (PABP) domain
View	Download	0.348	a.46.2	Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View	Download	0.336	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.331	a.76.1	Iron-dependent represor protein, dimerization domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: