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View Structure Prediction Details

Protein: wee1
Organism: Schizosaccharomyces pombe
Length: 877 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for wee1.

Description E-value Query
Range
Subject
Range
gi|223627 - gi|223627|prf||0903255A protein v-src
331.0 [0..272] [838..218]
SRC_RSVSA - Tyrosine-protein kinase transforming protein Src OS=Avian leukosis virus RSA GN=V-SRC PE=1 SV=5
gi|210189 - gi|210189|gb|AAA42565.1| src-p60 phosphoprotein
SRC_AVISR - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain rASV1441) GN=V-SRC P...
322.0 [0..302] [838..2]
gi|91080121 - gi|91080121|ref|XP_967736.1| PREDICTED: similar to CG4006-PA, isoform A [Tribolium castaneum]
321.0 [0..543] [876..142]
SRC_AVIST - Tyrosine-protein kinase transforming protein Src OS=Avian sarcoma virus (strain S2) GN=V-SRC PE=3 SV...
320.0 [0..302] [872..2]
gi|109020041 - gi|109020041|ref|XP_001104624.1| PREDICTED: v-akt murine thymoma viral oncogene homolog 3 [Macaca mu...
320.0 [0..372] [876..80]
gi|122891117, gi... - gi|37700244|ref|NP_937789.1| AKT2 kinase [Danio rerio], gi|182889760|gb|AAI65600.1| Akt2 protein [Da...
320.0 [0..454] [876..42]
gi|63363 - gi|63363|emb|CAA31595.1| unnamed protein product [Gallus gallus]
320.0 [0..288] [834..2]
AKT2 - v-akt murine thymoma viral oncogene homolog 2
319.0 [0..449] [876..37]

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Predicted Domain #1
Region A:
Residues: [1-165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSSNTSSH RSYGLRRSQR SMNLNRATLL APPTPSSLYD ANNSTSSTSS QKPNTSFTSL  60
   61 FGPRKQTTSS PSFSHAAPLH PLSPPSFTHS QPQIQAQPVP RRPSLFDRPN LVSRSSSRLG 120
  121 DSPSLSPVAQ VANPIHHTAP SPSDVRAFPI HKNASTGVKR SFFSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [166-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SMSNGAMSPP SHSPSPFLQS SQHIPPSTPA QKLRKKNNFD SFRISNSHIS PFASGSFSPF  60
   61 ATSSPNFLST STPAPPNSNN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [246-877]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANPSTLFSSI PSSRHTTSNH FPSNSAQSSL FSPTARPLTA RKLGFASSQT KSAVSNNHSR  60
   61 NSSKDASFMM KSFIPSNRSH PQTQQNESSL FSDNSMVNSS SNSFSLFPNA TLPNPPSSEL 120
  121 LTTPFQQIKP PSQVFMSTGL LSKQHRPRKN INFTPLPPST PSKPSTFVRP HSSSTDSPPS 180
  181 PSTPSNTQTD SYFIQRENTP TNHNSIPTIQ LEKSSMDFLR FDPPPSAVKT SHNYGLPFLS 240
  241 NQRCPATPTR NPFAFENTVS IHMDGRQPSP IKSRNNNQMS FAMEEEADVS QPSSSSFTLS 300
  301 FPSALTSSKV SSSTSHLLTR FRNVTLLGSG EFSEVFQVED PVEKTLKYAV KKLKVKFSGP 360
  361 KERNRLLQEV SIQRALKGHD HIVELMDSWE HGGFLYMQVE LCENGSLDRF LEEQGQLSRL 420
  421 DEFRVWKILV EVALGLQFIH HKNYVHLDLK PANVMITFEG TLKIGDFGMA SVWPVPRGME 480
  481 REGDCEYIAP EVLANHLYDK PADIFSLGIT VFEAAANIVL PDNGQSWQKL RSGDLSDAPR 540
  541 LSSTDNGSSL TSSSRETPAN SIIGQGGLDR VVEWMLSPEP RNRPTIDQIL ATDEVCWVEM 600
  601 RRKAGAIIYE GIHGSSSNPQ GDQMMEDWQV NV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.69897
Match: 2h8hA
Description: No description for 2h8hA was found.

Predicted functions:

Term Confidence Notes
protein kinase activity 5.4586557943719 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.93501454706421 bayes_pls_golite062009
kinase activity 4.7355970528347 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63692708178478 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.26787750561728 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
protein tyrosine kinase activity 1.3898059094397 bayes_pls_golite062009
transcription regulator activity 1.30988141770642 bayes_pls_golite062009
protein binding 1.22565748038754 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.20800936400261 bayes_pls_golite062009
molecular adaptor activity 1.17345244671832 bayes_pls_golite062009
DNA binding 1.17130513163489 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
receptor signaling protein activity 1.13658159660305 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.08185110129009 bayes_pls_golite062009
transcription repressor activity 0.959888295228949 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
transcription factor activity 0.919430701010326 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
kinase binding 0.443916188551908 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
protein kinase binding 0.285611963740145 bayes_pls_golite062009
signal transducer activity 0.270054246024761 bayes_pls_golite062009
molecular transducer activity 0.270054246024761 bayes_pls_golite062009
enzyme binding 0.268058321307564 bayes_pls_golite062009
MAP kinase activity 0.08504542461349 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0556163711947139 bayes_pls_golite062009
transmembrane receptor activity 0.00652065412910241 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle