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View Structure Prediction Details

Protein: uch1
Organism: Schizosaccharomyces pombe
Length: 222 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for uch1.

Description E-value Query
Range
Subject
Range
gi|109121004 - gi|109121004|ref|XP_001085879.1| PREDICTED: similar to Ubiquitin carboxyl-terminal hydrolase isozyme...
312.0 [0..2] [221..63]
UCHL3_BOVIN - Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Bos taurus GN=UCHL3 PE=2 SV=1
308.0 [0..2] [221..6]
gi|7710106, gi|7... - gi|7710106|ref|NP_057932.1| ubiquitin carboxyl-terminal esterase L3 [Mus musculus], gi|7578956|gb|AA...
307.0 [0..2] [221..6]
gi|61355555 - gi|61355555|gb|AAX41152.1| ubiquitin carboxyl-terminal esterase L3 [synthetic construct]
ENSPTRT00000010892 - null
UCHL3 - ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
tr|M3WRI6|M3WRI6... - Ubiquitin carboxyl-terminal hydrolase OS=Felis catus GN=UCHL3 PE=3 SV=1
307.0 [0..2] [221..6]
gi|54695586, gi|... - gi|61365555|gb|AAX42726.1| ubiquitin carboxyl-terminal esterase L3 [synthetic construct], gi|5469558...
306.0 [0..2] [221..6]
UCHL3_RAT - Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Rattus norvegicus GN=Uchl3 PE=1 SV=1
303.0 [0..2] [221..6]
UCHL3_PIG - Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Sus scrofa GN=UCHL3 PE=2 SV=1
302.0 [0..2] [221..6]

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Predicted Domain #1
Region A:
Residues: [1-222]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWRPLENTPE VLEPYLQKIG VQDASVFDLF SLEEIPEYIP RPVHALLFVF PSSGTKTIYK  60
   61 GSRILPKDSD KVLWYPQTIP NACGTIGLLH AVSNGELRRK VNENDFIKSL IRTAEGSSIE 120
  121 ERAKLIEDSK ELEALHAAFA GPPLEVEGSE EDVETDLHFI CFVKGKSKDD NHFYELDGRQ 180
  181 EGPVQHSEIE SDLLNAEVLS VIKNYIQSID SPFFSLVAIT TP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 84.0
Match: 1uchA
Description: DEUBIQUITINATING ENZYME UCH-L3 (HUMAN) AT 1.8 ANGSTROM RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
peptidase activity 3.28868056127375 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.01472402774099 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
hydrolase activity 2.29464693834116 bayes_pls_golite062009
endopeptidase activity 2.26699762664334 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
omega peptidase activity 1.7955048939859 bayes_pls_golite062009
binding 1.77258741259391 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.896934807256194 bayes_pls_golite062009
tubulin binding 0.75490638344179 bayes_pls_golite062009
microtubule binding 0.737305952322311 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
signal transducer activity 0.32811477573477 bayes_pls_golite062009
molecular transducer activity 0.32811477573477 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.168761518285256 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle