YRC Public Data Repository - Protein Structure Prediction

Protein:	trk2
Organism:	Schizosaccharomyces pombe
Length:	880 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trk2.

Description	E-value	Query Range	Subject Range
gi\|7799615 - gi\|7799615\|emb\|CAB91046.1\| high-affinity potassium uptake transporter [Debaryomyces occidentalis]	463.0	[0..20]	[873..49]
gi\|8099700 - gi\|8099700\|gb\|AAF72203.1\|AF267125_1 potassium transporter Trk1p [Candida albicans]	458.0	[0..7]	[869..26]
TRK2_YEAST - Low-affinity potassium transport protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN... TRK2 - Component of the Trk1p-Trk2p potassium transport system	456.0	[0..4]	[877..29]
gi\|4809179 - gi\|4809179\|gb\|AAD30128.1\|AF136181_1 potassium transporter [Kluyveromyces lactis]	445.0	[0..19]	[854..40]
gi\|49643776, gi\|... - gi\|50309269\|ref\|XP_454641.1\| unnamed protein product [Kluyveromyces lactis], gi\|49643776\|emb\|CAG9972... gi\|49643776 - gi\|49643776\|emb\|CAG99728.1\| KLLA0E15335p [Kluyveromyces lactis]	443.0	[0..19]	[854..40]
trk1 - potassium ion transporter Trk1 TRK1_SCHPO - Potassium transport protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=trk1 PE=3 SV...	424.0	[0..24]	[867..17]
gi\|42554669, gi\|... - gi\|46125803\|ref\|XP_387455.1\| hypothetical protein FG07279.1 [Gibberella zeae PH-1], gi\|42554669\|gb\|E...	417.0	[0..17]	[871..20]
gi\|49646900 - gi\|49646900\|emb\|CAG83287.1\| YALI0B17864p [Yarrowia lipolytica] gi\|49646900, gi\|... - gi\|50547129\|ref\|XP_501034.1\| YALI0B17864p [Yarrowia lipolytica], gi\|49646900\|emb\|CAG83287.1\| unnamed...	411.0	[0..20]	[871..13]
gi\|1076908, gi\|5... - gi\|550526\|gb\|AAC41667.1\| K+ transporter homologue [Schizosaccharomyces pombe], pir\|\|S50225 potassium...	410.0	[0..31]	[867..16]
gi\|18699011 - gi\|18699011\|gb\|AAL77222.1\| potassium transporter [Podospora anserina]	379.0	[0..23]	[852..57]

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Predicted Domain #1

Region A:
Residues: [1-122]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQLSGFSTNG SGSLNTIVCE KLLFKPNFVQ DSFIIGMTIL CSVILYGSGN LRYIDALLLA  60
   61 SGSCTQTGLQ PVDLTQISIY QQLTILLFGV LSTPITVNLG LTLFKLYFYN KRYDMVITNN 120
  121 KL

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.4
Match:	1f6gA
Description:	Potassium channel protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
potassium channel activity	6.97421456325005	bayes_pls_golite062009
voltage-gated potassium channel activity	6.93926669126255	bayes_pls_golite062009
voltage-gated cation channel activity	6.85197806762042	bayes_pls_golite062009
voltage-gated ion channel activity	6.68953517879833	bayes_pls_golite062009
voltage-gated channel activity	6.66667969342152	bayes_pls_golite062009
metal ion transmembrane transporter activity	5.60647618241473	bayes_pls_golite062009
cation channel activity	5.09551684793166	bayes_pls_golite062009
cation transmembrane transporter activity	4.88789838906314	bayes_pls_golite062009
ion transmembrane transporter activity	4.80939024913503	bayes_pls_golite062009
inward rectifier potassium channel activity	4.64079808042939	bayes_pls_golite062009
ion channel activity	4.50553553033114	bayes_pls_golite062009
gated channel activity	4.47618233399604	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	4.43208330555032	bayes_pls_golite062009
substrate-specific channel activity	4.39833449623615	bayes_pls_golite062009
passive transmembrane transporter activity	4.38139555510307	bayes_pls_golite062009
channel activity	4.38139555510307	bayes_pls_golite062009
transporter activity	2.77619896060397	bayes_pls_golite062009
transmembrane transporter activity	2.65613366364107	bayes_pls_golite062009
ligand-gated ion channel activity	2.63030973607925	bayes_pls_golite062009
ligand-gated channel activity	2.63030973607925	bayes_pls_golite062009
substrate-specific transporter activity	2.60593795082679	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [123-451]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RMTYTYHTVR RRDTPEPSKV GNRKIRVLLD QGNQMHRPVA PETKAEEAEH QENEKHHRHH  60
   61 FRLRKFANAI DRPSFFRGNT MPALPSYAGV RNSQENEDRT EALSPALGKR RMASIDNGSL 120
  121 SVVQNNARNN PVDFYIPSSF EESSFQTIPE DFEPQVHDHE NQTQLNHHLD NNSSISSHNP 180
  181 SLETANDGNQ ETVSSSNSNY STTRVDNDPH VASYSPQNSN FDHQAAATTN DAHQNVVRGS 240
  241 AITIAPTPVP RHNRRPIYFA DDTNGAEQEK GAHRLDGRGR KRGKSFAVTP TLHRNERSMS 300
  301 VLPFQLAKSF TSALPRRLTF NRTHTKAST

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.68
Match:	1dv4A
Description:	30S subunit
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [452-880]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPYLSYNA TVGRNSAFYA LTPVEREELA GIEYESLRIL TVILVVYFLF WHILGLVAFL  60
   61 IFIYTAKTSG RVVTDGGINR GWWAAFTSSS LFDNLGYSLN SDSLNSFQKA IFPQVLGTIL 120
  121 IFLGNTFFPI MLRFIIWIMI RTTRFSPNFQ QALYFLFEHP RRSFTLLFPS KTTWVLFLNL 180
  181 TLLNFASFFF FMVLDLGNSY VDKIPVGYRI MNAIFQNAAT RSAGFTVVDL SQIAPAVMVT 240
  241 YMFMMYISAY PIAMSIRQTN VYEERSLGIY AADTENDDDN NINNNNNDNN TPKRKNFLMD 300
  301 HIQRQLSHDL WYLFLGYFII TIVEGRRLES EAEPQFTLFA ILFEVISGYG TVGLSLGYKN 360
  361 DPSLTAQFRK ISKLVMVALQ IRGRHRGLPS ALDRAVLMPS DKNFDREEED YMRRHGKKNT 420
  421 NRADPVPSS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.08
Match:	2a79B
Description:	Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: